Shedding Patterns of Herpes Simplex Virus and Cytomegalovirus Among Chronic Dialysis Patients

Rf, Betts; Rg, Douglas; Rc, Pabico; Te, Talley; Yn, Yakub; Rb, Freeman

doi:10.1097/00002480-197201000-00065

Cited by 4 publications

(3 citation statements)

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“…From the clinical records, most of the respiratory, constitutional, or flu‐like symptoms also took place in September or December, but not in March or June. This may indicate that virus infections in cold seasons are more likely to be symptomatic or these viruses can be more easily coactivated in autumn and winter seasons (2). Further studies are needed to clarify whether these phenomena were worldwide or specific to Taiwan.…”

Section: Discussionmentioning

confidence: 99%

“…Increased susceptibility to infection is common in uremic patients due to their immunological defects, both in humoral and in cellular components (1). Because asymptomatic reactivation of viruses is not rare in immunocompromised patients, virus culture technique or serological study of viral activity in these patients may be worthwhile to prevent transmission of viruses from unnoticed foci (2). The purpose of this study was to follow the immunoglobulin G (IgG) antibody titers to six commonly encountered viruses in hemodialysis patients for a 2 year period to determine whether this group of patients had a different antibody response to viral activity compared to the normal population.…”

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A Two Year Follow‐Up Study of Common Virus Infections in Hemodialysis Patients in Taiwan

et al. 2002

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The study was designed to determine whether hemodialysis patients in Taiwan had a different antibody response to common virus infections compared to the normal population. Serum samples from 18 hemodialysis patients and 21 healthy volunteers were obtained every 3 months for 2 years. Geometric mean titers (GMTs) of immunoglobulin G (IgG) antibodies to cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), as well as Type A and Type B influenza viruses (Inf. A, Inf. B) were compared between the patient and the control groups. The prevalence rates and the rates of recurrent infection were similar in both groups. However, the patient group had a higher percentage of persons having persistent EBV and CMV infections (p < 0.05) and also higher GMTs of antibodies nearly the whole year round, especially significant in September and December (p < 0.05). In patients with hepatitis C, their GMTs of EBV, VZV, Inf. A, and Inf. B were higher than those without (p < 0.05).

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Section: Discussionmentioning

confidence: 99%

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A Two Year Follow‐Up Study of Common Virus Infections in Hemodialysis Patients in Taiwan

et al. 2002

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“…A discernible cytopathic effect in tissue culture usually develops within 24–48 h of inoculation. However, the simple isolation of HSV‐1 from respiratory secretions does not differentiate between true infection and a carrier state, since asymptomatic shedding does occur, especially in (critically) ill patients [19,36,50,90,91]. To solve this diagnostic problem, quantitative viral culture has been suggested [47], but no studies have evaluated this possibility to date.…”

Section: Diagnosismentioning

confidence: 99%

Herpes simplex virus type 1 and respiratory disease in critically-ill patients: real pathogen or innocent bystander?

Simoons-Smit¹,

Kraan²,

Beishuizen

et al. 2006

Clinical Microbiology and Infection

101

106

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Herpes simplex virus type 1 (HSV-1) has been associated with pulmonary disease, mostly in severely immunocompromised patients. After reactivation and shedding in the oropharynx, the virus may reach the lower respiratory tract by aspiration or by contiguous spread. HSV-1 can be detected in clinical specimens by virus culture or quantitatively by nucleic acid amplification techniques. With these techniques, HSV-1 is often detected in the respiratory secretions of critically-ill patients. However, a clear diagnosis of HSV-1 pneumonia is difficult to establish because clinical criteria, radiological features and laboratory findings all lack specificity. Lower respiratory tract HSV-1 infections have not been associated with specific risk-factors. There is also an absence of consistent data concerning the effect of antiviral treatment on the outcome of critically-ill patients. Further studies are needed to better define the pathogenic role of HSV-1 in the lower respiratory tract of these patients, to improve the diagnosis, and, especially, to assess the need for antiviral treatment in the individual patient.

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Cytomegalovirus

Craighead

2000

Pathology and Pathogenesis of Human Viral Disease

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Shedding Patterns of Herpes Simplex Virus and Cytomegalovirus Among Chronic Dialysis Patients

Cited by 4 publications

References 0 publications

A Two Year Follow‐Up Study of Common Virus Infections in Hemodialysis Patients in Taiwan

A Two Year Follow‐Up Study of Common Virus Infections in Hemodialysis Patients in Taiwan

Herpes simplex virus type 1 and respiratory disease in critically-ill patients: real pathogen or innocent bystander?

Cytomegalovirus

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