Sheep as an Experimental Model for Human ART: Novel Insights on Phenotypic Alterations in ART‐Derived Sheep Conceptuses

Abstract

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What does the cryopreserved oocyte look like? A fresh look at the characteristic oocyte features following cryopreservation

“…Moreover, comparative transcriptomic analyses of oocytes of different species have revealed that the bovine-human similarity is greater than mouse-human similarity (Sylvestre et al, 2013). Also, a number of recent studies have demonstrated close similarities between human and sheep embryos in metabolism and key stages before and after implantation development (Barry and Anthony, 2008;Loi et al, 2011;McMillen, 2001), and correspondingly, it is suggested that the sheep is an relevant experimental model for human assisted reproduction techniques (Loi et al, 2011). Therefore, we have used sheep as an animal model to evaluate the fundamental aspects of oocyte cryobiology in human (Asgari et al, 2011(Asgari et al, , 2012a(Asgari et al, , 2012bHosseini et al, 2012Hosseini et al, , 2015aHosseini et al, , 2015b.…”