Shenqi Lixin Decoction improves cardiac function in rats with adriamycin-induced heart failure through modulation of PGC-1α and mitochondrial apoptosis pathway

Zhu, Jian; Dou, Yan; Chen, Xiaoqing; Chen, Hua; Liu, Xuean; Lin, Genghai; Ruan, Fahui

doi:10.21037/atm-21-5350

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…On the one hand, TCM improves oxidative stress: Nuanxin capsule ( Lou, 2021 ) and Qishen Yiqi decoction ( Huang et al, 2021 ) can reduce the activities of ROS and MDA. Xinjierkang oral liquid ( Yu et al, 2013 ) and Shenqi Lixin decoction ( Zhuang et al, 2021 ) can increase the availability of NO and cGMP, improve the PKG channel, and enhance the protein and gene expression of SOD and Bcl-2. Poge Heart-Saving decoction ( Liu et al, 2020 ) inhibits the RASS system to reduce the production of AngII.…”

Section: Potential Mechanisms Of Tcm For Hfpefmentioning

confidence: 99%

“…Experimental studies have shown that the TCM Nuanxin capsule ( Lou, 2021 ), Shenfu decoction ( Huang, 2019 ), Simiao Yongan decoction ( Li et al, 2020 ), Shunxin decoction ( Jia et al, 2022 ), Shenqi Lixin decoction ( Zhuang et al, 2021 ), Jiawei Shenfu granules ( Liu, 2013 ), and Yiqihuoxue granules ( Ning, 2019 ) can regulate the volume of mitochondria and enhance the gene and protein expression of PGC-1α, PGC-1β, ERR-α and ERR-β to protect the ultrastructure. They can also activate the AMPK pathway to inhibit phosphorylation, inhibit caspase3 and increase Bcl-2 to prevent mitochondrial apoptosis and enhance OCR and ATP to improve respiratory function.…”

Section: Potential Mechanisms Of Tcm For Hfpefmentioning

confidence: 99%

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Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms

et al. 2023

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Heart failure with preserved ejection fraction accounts for a large proportion of heart failure, and it is closely related to a high hospitalization rate and high mortality rate of cardiovascular disease. Although the methods and means of modern medical treatment of HFpEF are becoming increasingly abundant, they still cannot fully meet the clinical needs of HFpEF patients. Traditional Chinese medicine is an important complementary strategy for the treatment of diseases in modern medicine, and it has been widely used in clinical research on HFpEF in recent years. This article reviews the current situation of HFpEF management, the evolution of guidelines, the clinical evidence and the mechanism of TCM in the treatment of HFpEF. The purpose of this study is to explore the application of TCM for HFpEF, to further improve the clinical symptoms and prognosis of patients and to provide a reference for the diagnosis and treatment of the disease.

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Section: Potential Mechanisms Of Tcm For Hfpefmentioning

confidence: 99%

Section: Potential Mechanisms Of Tcm For Hfpefmentioning

confidence: 99%

Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms

et al. 2023

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“…However, CHF patients after the current treatment still have poor prognosis and low 5-year survival rate ( Rosano and Vitale, 2018 ). Therefore, it is still urgent to find a new strategy for CHF therapy at this stage ( Zhuang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the mechanism of anti-chronic heart failure effect of qiweiqiangxin І granules based on metabolomics

Zhong

Li²,

Zhong³

et al. 2023

Front. Pharmacol.

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Background: Qiweiqiangxin І granules (QWQX І) is a traditional Chinese medicine preparation based on the basic theory of traditional Chinese medicine, which produces a good curative effect in treating chronic heart failure (CHF). However, its pharmacological effect and potential mechanism for CHF remain unknown.Aim of the study: The purpose of this study is to clarify the efficacy of QWQX І and its possible mechanisms.Materials and methods: A total of 66 patients with CHF were recruited and randomly assigned to the control or QWQX І groups. The primary endpoint was the effect of left ventricular ejection fraction (LVEF) after 4 weeks of treatment. The LAD artery of rats was occluded to establish the model of CHF. Echocardiography, HE and Masson staining were performed to evaluate the pharmacological effect of QWQX І against CHF. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) untargeted metabolomics was to screen endogenous metabolites in rat plasma and heart and elucidate the mechanism of QWQX І against CHF. Results: In the clinical study, a total of 63 heart failure patients completed the 4-week follow-up, including 32 in the control group and 31 in QWQX І group. After 4 weeks of treatment, LVEF was significantly improved in QWQX І group compared with the control group. In addition, the patients in QWQX І group had better quality of life than the control group. In animal studies, QWQX І significantly improved cardiac function, decreased B-type natriuretic peptide (BNP) levels, reduced inflammatory cell infiltration, and inhibited collagen fibril rate. Untargeted metabolomic analysis revealed that 23 and 34 differential metabolites were screened in the plasma and heart of chronic heart failure rats, respectively. 17 and 32 differential metabolites appeared in plasma and heart tissue after QWQX І treatment, which were enriched to taurine and hypotaurine metabolism, glycerophospholipid metabolism and linolenic acid metabolism by KEGG analysis. LysoPC (16:1 (9Z)) is a common differential metabolite in plasma and heart, which is produced by lipoprotein-associated phospholipase A2 (Lp-PLA2), hydrolyzes oxidized linoleic acid to produce pro-inflammatory substances. QWQX І regulates the level of LysoPC (16:1 (9Z)) and Lp-PLA2 to normal.Conclusion: QWQX І combined with western medicine can improve the cardiac function of patients with CHF. QWQX І can effectively improve the cardiac function of LAD-induced CHF rats through regulating glycerophospholipid metabolism and linolenic acid metabolism-mediated inflammatory response. Thus, QWQX I might provide a potential strategy for CHF therapy.

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Recent advances of traditional Chinese medicine against cardiovascular disease: overview and potential mechanisms

Dai,

Qiu,

et al. 2024

Front. Endocrinol.

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Cardiovascular disease (CVD) is the leading cause of human mortality worldwide. Despite Western medicine having made encouraging results in the clinical management of CVD, the morbidity, mortality, and disability rates of the disease remain high. Modern pharmacology has confirmed that traditional Chinese medicine (TCM), characterized by its multi-component, multi-target, and integrity, plays a positive and important role in the prevention and treatment of various CVDs in China, which has notable advantages in stabilizing disease, improving heart function, and enhancing the quality of life. Importantly, TCM is gradually being accepted by the international community due to its low cost, high safety, versatile bioactivity, and low toxicity. Unfortunately, comprehensive studies on the therapeutic effect of TCM on CVD and its mechanisms are very limited, which may restrict the clinical application of TCM in CVD. Therefore, this review is performed to analyze the pathogenesis of CVD, including inflammatory response, oxidative stress, mitochondrial dysfunction, pyroptosis, ferroptosis, dysbiosis of gut microbiota, etc. Moreover, we summarized the latest progress of TCM (formulas, extracts, and compounds) in curing CVD according to published literature from 2018 to 2023, as well as its mechanisms and clinical evidence. In conclusion, this review is expected to provide useful information and reference for the clinical application of TCM in the prevention and treatment of CVD and further drug development of CVD.

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Shenqi Lixin Decoction improves cardiac function in rats with adriamycin-induced heart failure through modulation of PGC-1α and mitochondrial apoptosis pathway

Cited by 3 publications

References 24 publications

Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms

Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms

Exploring the mechanism of anti-chronic heart failure effect of qiweiqiangxin І granules based on metabolomics

Recent advances of traditional Chinese medicine against cardiovascular disease: overview and potential mechanisms

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