SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties

Cordeiro, Bruna Mascaro; Oliveira, Indhira Dias; Alves, Maria Teresa de Seixas; Saba-Silva, Nasjla; Capellano, Andrea Maria; Cavalheiro, Sérgio; Dastoli, Patricia Alessandra; Toledo, Sílvia Regina Caminada de

doi:10.1007/s00381-014-2403-x

Cited by 16 publications

(13 citation statements)

References 31 publications

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“…This supports a similar finding by other investigators 10 11 who demonstrated that high Hh/Shh expression was significantly correlated with unfavorable prognostic factors. These results are consistent with most published reports that increased Shh expression is correlated with advanced stage cancers in gastric 26 , prostate 27 , medulloblastoma 28 and breast (Reviewed by) 29 . These results reinforce our claim that the Shh signaling activation loop is functioning to promote breast tumor formation, progression and proliferation.…”

Section: Discussionsupporting

confidence: 93%

Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh

Noman

Uddin

Rahman

et al. 2016

Sci Rep

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Dysregulation of Hedgehog (Hh) signaling pathway has been documented in mammary gland development and breast cancer (BC) progression. Despite the remarkable progress in therapeutic interventions, BC related mortality in Bangladesh increased in the last decade. Triple negative breast cancer (TNBC) still presents a critical therapeutic challenge. Thus effective targeted therapy is urgently needed. In this study, we report the clinicopathological characteristics and prognosis of BC patients from Bangladesh. Routine immunohistochemical analysis and high throughput RNA-Seq data from the TCGA library were used to analyze the expression pattern and association of high and low level of Shh expression in a collection of BC patients with a long-term follow-up. High levels of Shh were observed in a subset of BC tumors with poor prognostic pathological features. Higher level of Shh expression correlated with a significantly poorer overall survival of patients compared with patients whose tumors expressed a low level of Shh. These data support the contention that Shh could be a novel biomarker for breast cancer that is involved in mediating the aggressive phenotype of BC. We propose that BC patients exhibiting a higher level of Shh expression, representing a subset of BC patients, would be amenable to Shh targeted therapy.

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Section: Discussionsupporting

confidence: 93%

Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh

Noman

Uddin

Rahman

et al. 2016

Sci Rep

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“…The WNT pathway, Notch signaling and Hedgehog signaling pathway are known to regulate the self-renewal of normal stem cells. 33,34 Sam68 is an RNA binding protein with Src homology (SH) 2 and 3 domain binding sites, and can be coprecipitated with p85 PI3K. 35 AKT can activate beta-catenin by inhibiting GSK3beta.…”

Section: Discussionmentioning

confidence: 99%

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et al. 2015

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“…Deregulation of Wnt signaling has been shown to stimulate proliferation and maintenance of CSC populations in many cancers including colorectal cancer, hepatocellular carcinoma, medulloblastoma, and some leukemias (Cordeiro, et al, 2014, Dong, et al, 2016, Dow, et al, 2015, Petropoulos, et al, 2008, Wang, et al, 2016). However, studies in NB have shown conflicting evidence for the role of the Wnt pathway in tumorigenesis.…”

Section: Neural Crest Development and Nbmentioning

confidence: 99%

Neuroblastoma pathogenesis: deregulation of embryonic neural crest development

2017

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Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical and molecular perspective. Clinically, this cancer represents a wide range of phenotypes ranging from spontaneous regression of 4S disease to unremitting treatment-refractory progression and death of high risk metastatic disease. At a cellular level, the heterogeneous behavior of NB likely arises from an arrest and deregulation of normal neural crest development. In the present review, we summarize our current knowledge of neural crest development as it relates to pathways promoting ‘stemness’ and how deregulation may contribute to the development of tumor initiating CSCs. There is an emerging consensus that such tumor subpopulations contribute to the evolution of drug resistance, metastasis, and relapse in other equally aggressive malignancies. As relapsed, refractory disease remains the primary cause of death for neuroblastoma, the identification and targeting of CSCs or other primary drivers of tumor progression remains a critical, clinically significant goal for neuroblastoma. We will critically review recent and past evidence in the literature supporting the concept of CSCs as drivers of neuroblastoma pathogenesis.

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SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties

Abstract: Our results suggest the presence of activated developmental signaling pathways in MB, which are important for cell proliferation and maintenance, and that may be targeted for novel therapeutic options.

Cited by 16 publications

References 31 publications

Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh

Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh

Consort

Neuroblastoma pathogenesis: deregulation of embryonic neural crest development

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