Shining a (blue) light on hair follicle chronobiology and photobiomodulation

Paus, Ralf

doi:10.1111/exd.14271

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…Given that thyroid hormones have long been known to potently regulate mitochondrial functions in many extracutaneous cells and tissues [125][126][127], such as heat generation, nutrient storage and milk production by the various and highly plastic adipose tissue types [128,129], topically applicable T3 and T4 for dermatological applications may at least temporarily stimulate mitochondrial activity and/or biogenesis for clinically desirable outcome (see below and [130]).…”

Section: Thyroid Hormonesmentioning

confidence: 99%

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

Wikramanayake

Chéret

Sevilla

et al. 2022

Expert Opinion on Therapeutic Targets

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Introduction:The analysis of the role of the mitochondria in oxidative damage and skin aging is a significant aspect of dermatological research. Mitochondria generate most reactive oxygen species (ROS); however, excessive ROS are cytotoxic and DNA-damaging and promote (photo-)aging. ROS also possesses key physiological and regulatory functions and mitochondrial dysfunction is prominent in several skin diseases including skin cancers. Although many standard dermatotherapeutics modulate mitochondrial function, dermatological therapy rarely targets the mitochondria. Accordingly, there is a rationale for "mitochondrial dermatology"-based approaches to be applied to therapeutic research.Areas covered: This paper examines the functions of mitochondria in cutaneous physiology beyond energy (ATP) and ROS production. Keratinocyte differentiation and epidermal barrier maintenance, appendage morphogenesis and homeostasis, photoaging and skin cancer are considered. Based on related PubMed search results, the paper evaluates thyroid hormones, glucocorticoids, Vitamin D3 derivatives, retinoids, cannabinoid receptor agonists, PPARγ agonists, thyrotropin, and thyrotropinreleasing hormone as instructive lead compounds. Moreover, the mitochondrial protein MPZL3 as a promising new drug target for future "mitochondrial dermatology" is highlighted.Expert opinion: Future dermatological therapeutic research should have a mitochondrial medicine emphasis. Focusing on selected lead agents, protein targets, in silico drug design, and model diseases will fertilize a mito-centric approach.

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Section: Thyroid Hormonesmentioning

confidence: 99%

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

Wikramanayake

Chéret

Sevilla

et al. 2022

Expert Opinion on Therapeutic Targets

Self Cite

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The Skin and Endocrine Disorders

Paus,

Ramot

2024

Rook's Textbook of Dermatology

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Endocrine disorders can exert major effects on the human skin, leading to different signs and symptoms, including skin dryness, hair loss or excessive hair growth, pruritus, pigmentary changes and hyperhidrosis. This chapter reviews these changes and provides a practical approach to patients with suspected underlying endocrinological disorders. The chapter also discusses the latest findings showing that the skin serves as a complex (neuro‐) endocrine organ by itself, and thus possesses important practical implications for future dermatological therapy.

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Shining a (blue) light on hair follicle chronobiology and photobiomodulation

Cited by 2 publications

References 64 publications

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

The Skin and Endocrine Disorders

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