Shining a New Light on an Old Game – An Os^II‐Based Near‐IR Light Switch

Abstract

We present a high-yield synthesis, the spectroscopic, electrochemical, and photophysical characterization of a new near-IR Os II DNA light switch based on the pydppz ligand {pydppz = 3-(pyrid-2Ј-yl)dipyrido[3,2-a:2Ј,3Ј-c]phenazine}. The new compound represents, to the best of our knowledge, the first example of an [Os(tpy) 2 ]-like species able to intercalate into

Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand

“…Hence, this complex is a new addition to the growing family of metal complexes that behave as DNA "light-switches". [18][19][20][21][22][23][24][25] The lifetime data of the emission in the fully bound form were best fit to a biexponential function, giving rise to two distinct values of 6.1 and 0.16 μs (Fig. S9, ESI †).…”

Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

“…A wide variety of dppz-based complexes were designed, synthesized, and studied by modifying the bipyridine ancillary ligand or the dppz ligand [73][74][75][76][77][78], or changing the metal center to Re [79][80][81][82], Co [83,84], Cu [85,86], Rh [87][88][89][90], Os [91,92], Pt [31,[93][94][95], and Ir [96][97][98] cations.…”

“…This new species of Os(II) exhibits an absorption spectrum extending to 800 nm. Its emission characterized in aprotic organic solvent, by relatively high quantum yields and lifetimes in the order of hundreds of ns, is centered at 800 nm, and the complex represents the first example of an [Os(tpy) 2 ]-like species capable of intercalating into the DNA [91]. Moreover, it is also interesting to note that, despite the structural and chemical variation, it behaves as a true DNA OFF-ON light switch, like the analogous [Os(phen) 2 (dppz)] 2+ [150][151][152][153][154].…”

Photophysics of metal complexes

“…In aqueous solution the complex is non-emissive but becomes luminescent in the NIR in the presence of DNA. 87 Complexes of the form [Os(…”