Shock waves promote spinal cord repair via TLR3

Gollmann‐Tepeköylü, Can; Nägele, Felix; Graber, Michael; Pölzl, Leo; Lobenwein, Daniela; Hirsch, Jakob; An, Angela; Irschick, Regina; Röhrs, Bernhard; Kremser, Christian; Hackl, Hubert; Huber, Rosalie; Venezia, Serena; Hercher, David; Fritsch, Helga; Bonaros, Nikolaos; Stefanova, Nadia; Tancevski, Ivan; Meyer, Dirk; Grimm, Michael; Holfeld, Johannes

doi:10.1172/jci.insight.134552

Cited by 21 publications

(23 citation statements)

References 52 publications

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“…Fbxo2 is enriched in the inner ear and is a key regulator for age-related hearing loss [105]. Tlr3 is also presented in the inner ear and regulates immune responses [106,107], and Tlr4 acts as a mediator in protecting HCs from damage by exosomes secreted by SCs [32]. This suggests that Tlr3 might also have a protective role on inner ear's development.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the microRNA Transcriptomes and Proteomics of Cochlea Tissue-derived Small Extracellular Vesicles From Different Age of Mice After Birth

Jiang¹,

Ma²,

Han³

et al. 2021

Preprint

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The cochlea is an important sensory organ for both balance and sound perception, and the formation of the cochlea is a complex developmental process. The development of the mouse cochlea begins on embryonic day (E)9 and continues until postnatal day (P)21 when the hearing system is considered mature. Small extracellular vesicles (sEVs), with a diameter ranging from 30 nm to 200 nm, have been considered as a significant medium for information communication in both the processing of physiological and pathological. However, there are no studies exploring the role of sEVs in the development of the cochlea. Here, we isolated tissue-derived sEVs from the cochleae of FVB mice at P3, P7, P14, and P21 by ultracentrifugation. These sEVs were first characterized by transmission electron microscopy, nanoparticle tracking analysis, and western blotting. Next, we used small RNA-seq and mass spectrometry to characterize the microRNA transcriptomes and proteomics of cochlear sEVs from mice at different ages. Many microRNAs and proteins were discovered to be related with inner ear development, anatomical structure development, and the auditory nervous system development. These results all suggest that sEVs exist in the cochlea and are likely to be essential for the normal development of the auditory system. Our findings provide many sEV microRNA and protein targets for future studies of the roles of cochlear sEVs.

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Section: Discussionmentioning

confidence: 99%

Characterization of the microRNA Transcriptomes and Proteomics of Cochlea Tissue-derived Small Extracellular Vesicles From Different Age of Mice After Birth

Jiang¹,

Ma²,

Han³

et al. 2021

Preprint

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“…Regenerative and neuroprotection properties of SWT have been applied in spinal cord injury models. Lobenwein et al [79] along with Gollmann-Tepeköylü [80] indicate that Toll-like receptor (TLR) 3 signaling is involved in neuroprotection and spinal cord repair. Additionally, vascular endothelial growth factor (VEGF) [81] related mechanisms are postulated to be involved in this process.…”

Section: Neurologymentioning

confidence: 99%

Use of the Shock Wave Therapy in Basic Research and Clinical Applications—From Bench to Bedsite

Rola

Włodarczak²,

Barycki

et al. 2022

Biomedicines

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Shock Waves (SW) are acoustic disturbances that propagate through a medium carrying the energy. These specific sonic pulses are composed of two phases—high positive pressure, a rise time < 10 ns, and a tensile wave. Originally Shock Waveswereintroduced to clinical practice as a part of the lithotripsy therapy focused on disrupting calcific deposits in the body. Since that time, shock wave therapy (SWT) has gone far beyond the original application related to the destruction of kidney stones. In this narrative Review, we present basic clinical applications of the SWT along with the potential therapeutic application in clinical practice.

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“…Among the injury paradigms frequently used is a mechanical lesion. In larval zebrafish the spinal cord is completely transected at the level of the urogenital pore through an incision using either sharp glass [36,41] or an injection needle [24,42]. Alternatively, a stab lesion has been employed [26,43].…”

Section: Mechanical Lesionmentioning

confidence: 99%

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

Tsata

Wehner

2021

Cells

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The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identification of target cells that react to the injury and the cues directing their pro-regenerative responses. Among existing models of successful spinal cord regeneration, the zebrafish is arguably the most understood at a mechanistic level to date. Here, we review the spinal cord injury paradigms used in zebrafish, and summarize the breadth of neuron-intrinsic and -extrinsic factors that have been identified to play pivotal roles in the ability of zebrafish to regenerate central nervous system axons and recover function.

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Shock waves promote spinal cord repair via TLR3

Abstract: spin-off that aims to promote cardiac shock wave therapy.

Cited by 21 publications

References 52 publications

Characterization of the microRNA Transcriptomes and Proteomics of Cochlea Tissue-derived Small Extracellular Vesicles From Different Age of Mice After Birth

Characterization of the microRNA Transcriptomes and Proteomics of Cochlea Tissue-derived Small Extracellular Vesicles From Different Age of Mice After Birth

Use of the Shock Wave Therapy in Basic Research and Clinical Applications—From Bench to Bedsite

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

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