Short- and Long-Term Changes in Gastric Morphology and Histopathology Following Sleeve Gastrectomy in Diet-Induced Obese Rats

Martín, Marina; Burrell, Marı́a A.; Gómez-Ambrosi, Javier; Valentí, Víctor; Bueno, Álvaro; Ramírez, Beatriz; Becerril, Sara; Lancha, Andoni; Calderón, Pablo del Sol; Méndez‐Giménez, Leire; Catalán, Victoria; Rodríguez, Amaia; Fernández, Secundino; Muñoz-Navas, Miguel; Cienfuegos, Javier A.; Frühbeck, Gema

doi:10.1007/s11695-012-0606-3

Cited by 16 publications

(6 citation statements)

References 29 publications

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“…In our study, SG rats had significantly greater weight loss from 15 days postoperatively compared with sham rats, and then weights increased in both groups but remained lower in SG rats compared with sham rats at 24 weeks postoperatively. These results have been reported previously in Wistar rats at 5 weeks [20] and 16 weeks after SG [21]. Interestingly, food intake became similar from 15 days postoperatively and remained the same at 24 weeks postoperatively.…”

Section: Discussionsupporting

confidence: 91%

“…Interestingly, food intake became similar from 15 days postoperatively and remained the same at 24 weeks postoperatively. These results have also been reported in rats at 5 weeks [20], 12 weeks [21], and 16 weeks after SG [21]. In humans, weight regain after SG is also often observed after 2 or 3 postoperative years, and it is always observed in studies with 10-or 15-years postoperative follow-up [14][15][16][17].…”

Section: Discussionsupporting

confidence: 71%

“…However, only one study has reported the consequences of SG on the esophageal mucosa of Wistar rats, and it found more severe esophagitis in SG rats compared to sham rats at 12 weeks postoperatively [19]. Moreover, only three studies have assessed the consequences of SG on the gastric mucosa of Wistar rats, with a maximum follow-up of 16 weeks postoperatively, and they reported contrasting results, from normal fundic mucosa [20] to gastric foveolar hyperplasia and cystic glandular dilatation [21,22].…”

Section: Introductionmentioning

confidence: 99%

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No Long-Term Mucosal Lesions in the Esophagus but More Gastric Mucosal Lesions after Sleeve Gastrectomy in Obese Rats

Coupaye

Ribeiro-Parenti

Baratte

et al. 2023

JCM

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Sleeve gastrectomy (SG) often induces gastroesophageal reflux, with few and discordant long-term data on the risk of Barrett’s esophagus (BE) in operated patients. The aim of this study was to analyze the impact of SG on esogastric mucosa in a rat model at 24 weeks postoperatively, which corresponds to approximately 18 years in humans. After 3 months of a high-fat diet, obese male Wistar rats were subjected to SG (n = 7) or sham surgery (n = 9). Esophageal and gastric bile acid (BA) concentrations were measured at sacrifice, at 24 weeks postoperatively. Esophageal and gastric tissues were analyzed by routine histology. The esophageal mucosa of the SG rats (n = 6) was not significantly different in comparison to that of the sham rats (n = 8), with no esophagitis or BE. However, there was more antral and fundic foveolar hyperplasia in the mucosa of the residual stomach 24 weeks after SG than in the sham group (p < 0.001). Luminal esogastric BA concentrations did not differ between the two groups. In our study, SG induced gastric foveolar hyperplasia but no esophageal lesions at 24 weeks postoperatively in obese rats. Therefore, long-term endoscopic esophageal follow-up that is recommended in humans after SG to detect BE may also be useful for detecting gastric lesions.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

No Long-Term Mucosal Lesions in the Esophagus but More Gastric Mucosal Lesions after Sleeve Gastrectomy in Obese Rats

Coupaye

Ribeiro-Parenti

Baratte

et al. 2023

JCM

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“…Concerning the residual gastric mucosa, it has been reported that cell proliferation increased and apoptosis was down-regulated in the excluded gastric mucosa of biopsies from RYGB-operated obese patients [ 44 ]. In the remaining fundus of the rat after VSG, changes in gastric morphology with gastric foveola elongation, hyperplasia and cystic dilatation of the glands were reported [ 45 ]. In our rat model, we did not observe such changes in gastric morphology after VSG but, we found the residual stomach (both fundus and antrum) dilated.…”

Section: Discussionmentioning

confidence: 99%

Remodeling of the Residual Gastric Mucosa after Roux-En-Y Gastric Bypass or Vertical Sleeve Gastrectomy in Diet-Induced Obese Rats

et al. 2015

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Whereas the remodeling of intestinal mucosa after bariatric surgeries has been the matter of numerous studies to our knowledge, very few reported on the remodeling of the residual gastric mucosa. In this study, we analyzed remodeling of gastric mucosa after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) in rats. Diet-induced obese rats were subjected to RYGB, VSG or sham surgical procedures. All animals were assessed for food intake, body-weight, fasting blood, metabolites and hormones profiling, as well as insulin and glucose tolerance tests before and up to 5 weeks post-surgery. Remodeling of gastric tissues was analyzed by routine histology and immunohistochemistry studies, and qRT-PCR analyses of ghrelin and gastrin mRNA levels. In obese rats with impaired glucose tolerance, VSG and RYGB caused substantial weight loss and rats greatly improved their oral glucose tolerance. The remaining gastric mucosa after VSG and gastric pouch (GP) after RYGB revealed a hyperplasia of the mucous neck cells that displayed a strong immunoreactivity for parietal cell H+/K+-ATPase. Ghrelin mRNA levels were reduced by 2-fold in remaining fundic mucosa after VSG and 10-fold in GP after RYGB. In the antrum, gastrin mRNA levels were reduced after VSG in line with the reduced number of gastrin positive cells. This study reports novel and important observations dealing with the remaining gastric mucosa after RYGB and VSG. The data demonstrate, for the first time, a hyperplasia of the mucous neck cells, a transit cell population of the stomach bearing differentiating capacities into zymogenic and peptic cells.

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“…A duodenal switch consists of a vertical gastrectomy followed by bypassing a large portion of the small intestine (39). Noteworthy, animal studies have found contradictory findings regarding gastric sleeve morphology (35,40). From a histological point of view, the gastric mucosa undergoes changes with increased numbers of mucous neck cells and increased numbers of enlarged parietal cells.…”

Section: Gastrointestinal Acid Secretion After Sleeve Gastrectomy and Roux-en-y Gastric Bypassmentioning

confidence: 99%

Adaptations in gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass

Steenackers

Vanuytsel

Augustijns

et al. 2021

The Lancet Gastroenterology & Hepatology

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Short- and Long-Term Changes in Gastric Morphology and Histopathology Following Sleeve Gastrectomy in Diet-Induced Obese Rats

Abstract: After SG gastric macro- and microscopic changes with functional implications in both the short and long term take place.

Cited by 16 publications

References 29 publications

No Long-Term Mucosal Lesions in the Esophagus but More Gastric Mucosal Lesions after Sleeve Gastrectomy in Obese Rats

No Long-Term Mucosal Lesions in the Esophagus but More Gastric Mucosal Lesions after Sleeve Gastrectomy in Obese Rats

Remodeling of the Residual Gastric Mucosa after Roux-En-Y Gastric Bypass or Vertical Sleeve Gastrectomy in Diet-Induced Obese Rats

Adaptations in gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass

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