Short and Long Term Failure of the Modular Oncology Knee Prosthesis

Gitelis, Steven; Yergler, Jeffrey D; Sawlani, Neal; Schiff, Adam; Shott, Susan

doi:10.3928/01477447-20080401-10

Cited by 14 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The limb salvage rate for all patients in this study was 90%, demonstrating that many complications were successfully managed, particularly in the absence of infection. This result leads us to conclude that endoprosthetic reconstruction is warranted in a tumor population, a conclusion shared by others [1,5,7,8,11,14,16,19,24,27]. Whether the limb salvage rate will change as patients enter their third and fourth decades following their index procedure can only be answered through further observation over time.…”

Section: Discussionmentioning

confidence: 72%

Late Complications and Survival of Endoprosthetic Reconstruction after Resection of Bone Tumors

Shehadeh

Noveau

Malawer

et al. 2010

Clinical Orthopaedics &Amp; Related Research

125

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 72%

Late Complications and Survival of Endoprosthetic Reconstruction after Resection of Bone Tumors

Shehadeh

Noveau

Malawer

et al. 2010

Clinical Orthopaedics &Amp; Related Research

125

View full text Add to dashboard Cite

show abstract

“…2,4 However, the reported complication rate of tumor prostheses remains 5 to 10 times higher than the respective rates seen in routine total joint arthroplasties. [5][6][7][8] These include mechanical failures, such as breakage or fracture of the implant and instability due to wear, and biologic failures. such as infection, aseptic loosening, and wound or soft tissue breakdowns.…”

Section: Cme Articlementioning

confidence: 99%

Infected Tumor Prostheses

Mavrogenis¹,

Papagelopoulos²,

Coll-Mesa³

et al. 2011

Orthopedics

View full text Add to dashboard Cite

Infection of tumor prostheses has been a major concern because of the extensive soft tissue dissection, long operating times, and patients' immunosuppression by cancer and adjuvant treatments. Infections most often present within 2 years postoperatively, with approximately 70% of postoperative deep infections presenting within 12 months after surgery. They are typically low organism burden infections, the pathogenesis of which is related to bacteria growing in biofilms. Staphylococci are the most common pathogens involved in prosthetic joint infections, accounting for approximately 50% of infections overall, followed by streptococci, enterococci, Enterobacteriaceae species, Pseudomonas aeruginosa, and anaerobe species. Multiple pathogens may be isolated in approximately 25% of cases, with the most common combination being coagulase-negative Staphylococcus and group-D Streptococcus. Early diagnosis and appropriate treatment are necessary. However, diagnosis may be challenging because clinical symptoms are highly variable and numerous preoperative and intraoperative diagnostic laboratory tests are nonspecific. In most cases, a 1- or 2-stage revision surgery is necessary for eradicating the megaprosthetic infection. Prevention of infection is important. The future will see technical advances for infections of tumor prostheses in areas such as microbiological diagnostics and biofilm-resistant prostheses.

show abstract

“…The rate of infection of megaprostheses has been comparable to that associated with other methods of reconstruction following limb salvage surgery, such as autograft or allograft reconstruction [8][9][10]. However, it remains five-to ten-fold higher than the rates following routine total joint arthroplasties [11,12].…”

mentioning

confidence: 98%

Infected Prostheses after Lower-Extremity Bone Tumor Resection: Clinical Outcomes of 100 Patients

Mavrogenis

Pala

Angelini

et al. 2015

Surgical Infections

View full text Add to dashboard Cite

Megaprosthesis reconstructions may be infected in 8.6% of cases. Infections more commonly occur late, caused usually by S. epidermidis. The survival rate is higher with cementless megaprosthesis reconstructions and no different with respect to the type of tumor or megaprosthesis or the adjuvant treatments. One-stage revision is effective for acute post-operative infections; however, two-stage revision surgery is necessary for early and late infections. The rate of amputation because of occurrence or persistence of megaprosthesis infection is 21%.

show abstract

Short and Long Term Failure of the Modular Oncology Knee Prosthesis

Cited by 14 publications

References 36 publications

Late Complications and Survival of Endoprosthetic Reconstruction after Resection of Bone Tumors

Late Complications and Survival of Endoprosthetic Reconstruction after Resection of Bone Tumors

Infected Tumor Prostheses

Infected Prostheses after Lower-Extremity Bone Tumor Resection: Clinical Outcomes of 100 Patients

Contact Info

Product

Resources

About