Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity

Vanyushin, B. F.; Khavinson, V. Kh.

doi:10.1007/978-3-319-27186-6_5

Cited by 14 publications

(6 citation statements)

References 26 publications

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“…The physical channel of management and implementation of programs for the development and functioning of the human body is very sensitive to the effects of external physical factors [14,15], which we note in our study. This is explained by the fact that the main link of the trigger mechanism of the body's response to an external factor is the change in the cell's electrical status, a group of cells due to changes in the electrical charges of macromolecules, and the endogenous synthesis and release of neurotransmitters depends primarily on the amount of electrical energy and its dissipation mechanism [16,17].…”

Section: Discussionmentioning

confidence: 75%

Influence of “Novumedical” Equipment on Non-Specific Resistance of the Organism Taking Into Account Adaptation Reactions

Shuvalova

Golovan

Lee³

2019

EUREKA: Health Sciences

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Studies have shown the effectiveness and perspective of using «NovuMedical» devices for the purpose of primary and secondary prevention of diseases, increasing the personal interest of patients in extending the period of active longevity due to regular recovery at home. The preventive effect of the equipment is not directed against the symptoms of the disease, but to increase the body's resistance. Before treatment, the normal type of adaptive response was detected in 75 % of patients, the workout reaction was noted in 45.4 %, the calm activation reaction – 23.2 %, the reaction of increased activation in 6.2 % of cases, and the stress response was recorded in 25.2 %. After the treatment, the workout reaction was detected in 44.1 % of cases, the calm activation reaction – 22.2 %, the increased activation zone – 33.3 %. The preformed factors used in the apparatuses are a bioregulator in the broad sense of modulating the physiological functions of the body, which makes it possible to “rejuvenate” the sick organism, at least to equalize the biological and passport age, to restore the original potential of sanogenetic reactions. Apparatus for home use can be the basis for the primary population prevention and secondary individual prevention of a wide range of diseases and premature aging.

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Section: Discussionmentioning

confidence: 75%

Influence of “Novumedical” Equipment on Non-Specific Resistance of the Organism Taking Into Account Adaptation Reactions

Shuvalova

Golovan

Lee³

2019

EUREKA: Health Sciences

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“…This research has led to the conclusion that the biological effects of peptides are based on their ability to regulate gene expression and protein synthesis through such DNA-peptide interactions [23,24].…”

Section: Biological Effects Of Peptidesmentioning

confidence: 99%

“…These peptides modulate the expression of the CLE family of genes that code known endogenous regulatory peptides, the KNOX1 genes (transcription factor genes), and the GRF family of genes (growth regulatory factors) that code for the corresponding DNA-binding proteins, such as topoisomerases, nucleases, etc. [16,24].…”

Section: Peptide Regulation Of Cell Differentiationmentioning

confidence: 99%

Peptide Regulation of Gene Expression: A Systematic Review

et al. 2021

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Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems. The mechanism of such action of peptides involves their ability to regulate gene expression and protein synthesis in plants, microorganisms, insects, birds, rodents, primates, and humans. Short peptides, consisting of 2–7 amino acid residues, can penetrate into the nuclei and nucleoli of cells and interact with the nucleosome, the histone proteins, and both single- and double-stranded DNA. DNA–peptide interactions, including sequence recognition in gene promoters, are important for template-directed synthetic reactions, replication, transcription, and reparation. Peptides can regulate the status of DNA methylation, which is an epigenetic mechanism for the activation or repression of genes in both the normal condition, as well as in cases of pathology and senescence. In this context, one can assume that short peptides were evolutionarily among the first signaling molecules that regulated the reactions of template-directed syntheses. This situation enhances the prospects of developing effective and safe immunoregulatory, neuroprotective, antimicrobial, antiviral, and other drugs based on short peptides.

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“…A risk of any pathology is conditioned by not only genetic but also epigenetic factors. Main epigenetic factors include -the food quality, life style, ecological environment [6,7]. All these factors influence appearance and progress of many acquired diseases, which genetic predisposition is inherent to each human.…”

Section: Introductionmentioning

confidence: 99%

«novumedical» Devices Are the Vector of Realization of P4 Medicine Course

Shuvalova

2018

EUREKA: Health Sciences

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The issues of modern personified preventive medicine, the development of modern methods, courses, technologies of healthy active longevity are in the focus of attention and these issues are relevant. The purpose of the article is to study the influence on prevention of diseases, improving the quality of life by massage and thermal device «NovuМedical» intended for home use. In the research the analysis of results of the equipment use in 140 patients aged from 61 to 78 years is conducted by the method of comparison and grouping. A significant improvement in the quality of life, stabilization of the psycho-emotional state and blood pressure is noted among 93.5 % of patients. Reduction of pain syndrome is noted among 85 % of patients, reduction in serum cholesterol is noted among 30 %, glucose normalization is noted among 25 % of patients, and 46 % has a tendency to reduce it. A tendency to normalize blood coagulation function is noted among 40 % of patients, that makes prevention and correction of diseases legitimate and necessary, timely with the help of «NovuMedical» devices at home. «NovuMedical» devices allows both to improve well-being, normalize homeostasis, and to form in patients a system of knowledge and skills to improve the quality of life, and include them in active actions for health self-improvement, mental and physical self-improvement. This participatory approach leads to a fundamentally new paradigm of caring and managing health, when not only the social institutions of the state, but also patients themselves are direct and active participants in the process of preserving and strengthening their own health.

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Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity

Cited by 14 publications

References 26 publications

Influence of “Novumedical” Equipment on Non-Specific Resistance of the Organism Taking Into Account Adaptation Reactions

Influence of “Novumedical” Equipment on Non-Specific Resistance of the Organism Taking Into Account Adaptation Reactions

Peptide Regulation of Gene Expression: A Systematic Review

«novumedical» Devices Are the Vector of Realization of P4 Medicine Course

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