Short sleep duration increases the risk of hyperuricemia among Chinese adults: findings from the China Health and Nutrition Survey

Yu, Xixi; Gong, Shaomin; Chen, Jing; Zhang, Han; Shen, Ziyan; Gu, Yan; Lv, Shiqi; Zhang, Di; Wang, Yulin; Ding, Xiaoqiang; Zhang, Xiaoyan

doi:10.1016/j.sleep.2021.05.014

Cited by 12 publications

(17 citation statements)

References 23 publications

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“…Most of these studies supported short sleep duration as a potential risk factor for hyperuricemia (15)(16)(17). For example, a study of 4,555 Chinese adults found that short sleep duration was associated with higher urate levels (15).…”

Section: Discussionmentioning

confidence: 97%

“…Our traditional observational analysis results were consistent with and extended previous work. Several recent observational studies have investigated the associations between sleep duration and hyperuricemia (15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…Logistic regressions were performed to assess the observational association between sleep duration and hyperuricemia in the univariable models. To account for the impact of potential confounders, we conducted multivariable logistic models with adjustments for a number of covariates based on our prior knowledge and previous studies (15)(16)(17)(18), including age, sex (only for the model with overall participants), Townsend deprivation index, education level, employment status, smoking status, alcohol consumption, physical activity, fruit and vegetable intake, HDL-C, LDL-C, TG, TC: HDL-C ratio, WBC count, obesity, hypertension, and diabetes mellitus. Odds ratios (ORs) with 95% confidence intervals (95% CIs) and corresponding P-values were reported.…”

Section: Cross-sectional Analysismentioning

confidence: 99%

“…Previous studies have identified extreme sleep duration as a critical lifestyle risk factor for a series of chronic diseases (11), such as diabetes mellitus (12) and chronic kidney disease (13,14). Recently, several studies have suggested that sleep duration may be a potentially modifiable risk factor for hyperuricemia (15)(16)(17)(18). Interestingly, one of those studies based on data from the China Health and Nutrition Survey (CHNS) found a significant association between sleep duration and hyperuricemia only in females but not in males (16).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, several studies have suggested that sleep duration may be a potentially modifiable risk factor for hyperuricemia (15)(16)(17)(18). Interestingly, one of those studies based on data from the China Health and Nutrition Survey (CHNS) found a significant association between sleep duration and hyperuricemia only in females but not in males (16). That said, the association between sleep duration and hyperuricemia may be sex-specific.…”

Section: Introductionmentioning

confidence: 99%

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Linear and non-linear Mendelian randomization analyses of sex-specific associations between sleep duration and hyperuricemia

Zou

Wang

et al. 2022

Front. Nutr.

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BackgroundObservational studies have suggested a potential non-linear association between sleep duration and hyperuricemia. However, the causal nature and sex-specific differences are poorly understood. We aimed to determine the shape of sex-specific causal associations between sleep duration and hyperuricemia in the UK Biobank.MethodsLogistic regression was used to investigate the observational association between self-reported sleep duration and hyperuricemia among 387,980 white British participants (mean age: 56.9 years and 46.0% males). Linear and non-linear Mendelian Randomization (MR) analyses were performed to assess the causal association between continuous sleep duration and hyperuricemia. The causal effects of genetically predicted short (<7 h) and long (>8 h) sleep durations on hyperuricemia were further estimated, respectively.ResultsTraditional observational analysis suggested U- and J-shaped associations between sleep duration and hyperuricemia in females and males, respectively. Linear MR did not support the causal effect of sleep duration on hyperuricemia. Non-linear MR demonstrated an approximately U-shaped causal association between continuous sleep duration and hyperuricemia in overall participants and females, but not in males. Genetically predicted short sleep duration was significantly associated with hyperuricemia in females (OR [95% CI]: 1.21 [1.08–1.36]; P = 0.001), but not in males (1.08 [0.98–1.18]; P = 0.137). By contrast, genetically predicted long sleep duration was not significantly associated with the risk of hyperuricemia in either females or males.ConclusionGenetically predicted short sleep duration is a potential causal risk factor for hyperuricemia for females but has little effect on males. Long sleep duration does not appear to be causally associated with hyperuricemia.

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Section: Discussionmentioning

confidence: 97%