Short term air pollution exposure during pregnancy and associations with maternal immune markers

Yount, C.S.; Scheible, K.; Thurston, S.W.; Qiu, X.; Ge, Y.; Hopke, P.K.; Lin, Y.; Miller, R.K.; Murphy, S.K.; Brunner, J.; Barrett, E.; O'Connor, T.G.; Zhang, J.; Rich, D.Q.

doi:10.1016/j.envres.2024.119639

Environmental Research

2024

DOI: 10.1016/j.envres.2024.119639

|View full text |Cite

Short term air pollution exposure during pregnancy and associations with maternal immune markers

C.S. Yount,

K. Scheible,

S.W. Thurston

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Impact of air pollution exposure on cytokines and histone modification profiles at single-cell levels during pregnancy

Jung,

Aguilera,

Kaushik

et al. 2024

Sci. Adv.

View full text Add to dashboard Cite

Fine particulate matter (PM 2.5 ) exposure can induce immune system pathology via epigenetic modification, affecting pregnancy outcomes. Our study investigated the association between PM 2.5 exposure and immune response, as well as epigenetic changes using high-dimensional epigenetic landscape profiling using cytometry by time-of-flight (EpiTOF) at the single cell. We found statistically significant associations between PM 2.5 exposure and levels of certain cytokines [interleukin-1RA (IL-1RA), IL-8/CXCL8, IL-18, and IL-27)] and histone posttranslational modifications (HPTMs) in immune cells (HPTMs: H3K9ac, H3K23ac, H3K27ac, H2BK120ub, H4K20me1/3, and H3K9me1/2) among pregnant and nonpregnant women. The cord blood of neonates with high maternal PM 2.5 exposure showed lower IL-27 than those with low exposure. Furthermore, PM 2.5 exposure affects the co-modification profiles of cytokines between pregnant women and their neonates, along with HPTMs in each immune cell type between pregnant and nonpregnant women. These modifications in specific histones and cytokines could indicate the toxicological mechanism of PM 2.5 exposure in inflammation, inflammasome pathway, and pregnancy complications.

show abstract

Impact of air pollution exposure on cytokines and histone modification profiles at single-cell levels during pregnancy

Jung,

Aguilera,

Kaushik

et al. 2024

Sci. Adv.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Short term air pollution exposure during pregnancy and associations with maternal immune markers

Cited by 1 publication

References 56 publications

Impact of air pollution exposure on cytokines and histone modification profiles at single-cell levels during pregnancy

Impact of air pollution exposure on cytokines and histone modification profiles at single-cell levels during pregnancy

Contact Info

Product

Resources

About