Short-term bone marrow suppression in differentiated thyroid cancer patients after radioactive iodine treatment

Yi, Wook; Kim, Bo Hyun; Kim, Mijin; Ryang, So Ree; Jang, Min Hee; Kim, Jeong Mi; Kim, Eun Heui; Jeon, Yun Kyung; Kim, Sang Soo; Kim, In Joo

doi:10.1507/endocrj.ej20-0242

Cited by 10 publications

(12 citation statements)

References 21 publications

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“…Platelets can rebound after correction of sepsis, and thrombocytopenia may be associated with infection-mediated destruction [ 7 ]. Bone marrow suppression may be a factor in some septic patients [ 8 ]. Non-catalytic receptors such as toll-like receptors (TLRs) have been suggested as possible mediators of sepsis-associated thrombocytopenia [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

Qiao

2022

Contrast Media & Molecular Imaging

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Thromboelastography (TEG) is usually used to monitor coagulation disorder clinically. It is unclear whether TEG has association with urosepsis and sepsis-induced coagulopathy (SIC). The purpose of this study was to investigate the clinical significance of TEG parameters in urosepsis. 90 patients who were admitted to the Emergency Ward and Emergency Intensive Care Unit (EICU) of Ren Ji Hospital affiliated to Shanghai Jiao Tong University School of Medicine due to urinary infection from February 2014 to February 2022 were retrospectively studied. Urosepsis patients and non-sepsis patients were separately investigated according to the final discharge diagnosis and Sepsis 3.0. At the same time, patients with urosepsis were further divided into groups of SIC and non-SIC based on the definition of SIC. The data of clinical features, laboratory biomarkers, and TEG parameters were collected and analyzed. There were significant differences in white blood cell count, C-reactive protein (CRP), platelet count, procalcitonin (PCT), fibrinogen (FIB), international normalized ratio (INR), prothrombin time (PT), D-dimer, and incidence of urinary tract obstruction between the urosepsis group and non-sepsis group ( P < 0.05 ). In the comparison with non-sepsis group, K value was significantly lower (P = 0.006), while α-angle ( P = 0.003 ) and clot index (CI) ( P = 0.048 ) were significantly higher in urosepsis group. The area under the K value curve excluding urosepsis was 0.667. The areas under CI and α-angle curves for diagnosing urosepsis were 0.682 and 0.621, respectively. The patients in SIC group had significantly higher K value, lower α-angle, and maximum amplitude (MA) than those in non-SIC group ( P < 0.05 ). Coagulopathy is prone to occur in patients with urosepsis. TEG is helpful for assessment of hypercoagulable state in urosepsis and prediction of hypocoagulability in SIC patients implying the dynamic process of DIC.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

Qiao

2022

Contrast Media & Molecular Imaging

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“…Although the most common side effect is decreased saliva production, it is not usually a serious problem. Rare side effects may occur in the lacrimal glands, bone marrow, lungs, and reproductive organs [3,[6][7][8].…”

Section: Introduction mentioning

confidence: 99%

The Effect of I-131 Treatment on Complete Blood Count

Sahutoglu,

Cetin,

Atilgan

2024

Atom Indo.

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Radioactive iodine-131 (RAI) treatment may cause suppression in the bone marrow. In this study, hemoglobin levels, leukocyte, thrombocyte, and lymphocyte counts will be compared before total thyroidectomy and 6 months after RAI treatment. 97 patients (76 females, 21 males) with a diagnosis of well-differentiated thyroid cancer who had undergone total thyroidectomy and received 50-200 mCi RAI treatment were included in the study. Hemoglobin levels, leukocyte, thrombocyte, and lymphocyte counts of the patients in the last month before the treatment and in the sixth month after the treatment were compared retrospectively. When the whole patients were analyzed, hemoglobin levels, leukocyte, thrombocyte, and lymphocyte counts in pretreatment were statistically lower than after-treatment values. While hemoglobin levels of female patients were similar before and after treatment, lymphocyte, thrombocyte, and leukocyte counts were statistically lower before treatment. Hemoglobin levels, leukocyte,and thrombocyte counts were similar before and after treatment, while lymphocytes decreased significantly after RAI treatment. Thyroid cancer patients who received 50-200 mCi RAI treatment after total thyroidectomy, have bone marrow suppression but are still in normal mean value ranges. This mild bone marrow suppression is more prominent in female patients than in male patients.

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“…Temporary anemia, leukopenia, and thrombocytopenia may occur within the first month after a single RAI therapy [ 8 ]. Several studies reported improvement in complete blood cell (CBC) counts at 6 months to 1 year after treatment [ 9 , 10 ], while in other studies, the decrease in leukocytes [ 11 ], platelets [ 8 , 11 , 12 ], and lymphocytes [ 12 ] persevered.…”

Section: Introductionmentioning

confidence: 99%

The assessment of the Long Term Hematologic Effects in Differentiated Thyroid Cancer Patients Treated with Radioactive Iodine

Sönmez¹,

Bektas²,

Erkut³

et al. 2021

Tjh

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Objective: Radioactive iodine (RAI) therapy may cause hematologic abnormalities. The aim of this study is to evaluate long-term hematologic effects in differentiated thyroid cancer (DTC) patients after RAI therapy. Materials and Methods: A total of 1389 patients with DTC who were treated with RAI were retrospectively evaluated. Complete blood cell counts before RAI therapy and at last follow-up and hematologic malignancy development were obtained from the electronic records. Results: In the long-term analysis, thrombocytopenia and lymphopenia were observed significantly in patients over 60 years of age. Thrombocytopenia was observed more frequently in men. Leukopenia, thrombocytopenia, and lymphopenia were observed significantly with doses of >175 mCi. Thrombocytopenia and lymphopenia were observed significantly with multiple dose administration. Higher frequencies of anemia, thrombocytopenia, leukopenia, neutropenia, and lymphopenia were found in patients with advanced-stage disease. However, patients with advanced-stage disease had higher doses and more multiple doses than patients with early-stage disease. The rate of hematologic malignancy was found to be higher than in the general population. Conclusion: We suggest that cytopenia be surveyed more carefully in patients older than 60 years of age. The most important risk factor for lower platelets after RAI therapy is male gender. Clinically, the most important predictor for cytopenia is advanced disease stage, which is related to the combined effects of applied high dose activity, multiple dose applications, and high tumor burden.

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Short-term bone marrow suppression in differentiated thyroid cancer patients after radioactive iodine treatment

Cited by 10 publications

References 21 publications

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

The Effect of I-131 Treatment on Complete Blood Count

The assessment of the Long Term Hematologic Effects in Differentiated Thyroid Cancer Patients Treated with Radioactive Iodine

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