Short-term changes and correlations of plasma spexin, kisspeptin, and galanin levels after laparoscopic sleeve gastrectomy

Atabey, Mustafa; Aykota, Muhammed Raşid; Özel, Mehmet İlker; Arslan, Gokhan

doi:10.1007/s00595-021-02240-6

Cited by 6 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The negative correlation between SPX and body fat mass is in line with earlier observations in adult individuals with obesity, in which a negative association between SPX and body fat percentage was reported [ 38 ]. Consistent with this, significantly lower SPX levels were reported in children with high compared to normal fat mass [ 39 ].…”

Section: Discussionsupporting

confidence: 91%

Circulating Spexin Is Associated with Body Mass Index and Fat Mass but Not with Physical Activity and Psychological Parameters in Women across a Broad Body Weight Spectrum

Suhs

Stengel

Rudolph

et al. 2022

JCM

View full text Add to dashboard Cite

Spexin (SPX) is a novel, widely expressed peptide, with anorexigenic effects demonstrated in animal models and negatively correlated with body mass index (BMI) in humans. It increases locomotor activity in rodents and is elevated in human plasma following exercise. Studies have also shown an effect of stress and anxiety on SPX’s expression in different brain structures in animals. The relationships between plasma SPX and physical activity, body composition, and patient-reported outcomes such as perceived stress, depressiveness, anxiety, and eating behaviors are unknown and were examined in this study over a wide BMI range. A total of 219 female (n = 68 with anorexia nervosa; n = 79 with obesity; n = 72 with normal weight) inpatients were enrolled. Perceived stress (PSQ 20), anxiety (GAD 7), depressiveness (PHQ 9), and eating disorder pathology (EDI 2), as well as BMI, bioimpedance analysis, and accelerometry, were measured cross-sectionally at the beginning of treatment and correlated with plasma SPX levels (measured by ELISA) obtained at the same time. Plasma SPX levels were negatively associated with BMI (r = −0.149, p = 0.027) and body fat mass (r = −0.149, p = 0.04), but did not correlate with perceived stress, anxiety, depressiveness, eating behavior, energy expenditure, and physical activity (p > 0.05). The results replicate the negative correlation of SPX with BMI and fat mass, but do not support the hypothesis that peripheral SPX plays a role in the regulation of stress, depressiveness, anxiety, eating behavior, or physical activity.

show abstract

Section: Discussionsupporting

confidence: 91%

Circulating Spexin Is Associated with Body Mass Index and Fat Mass but Not with Physical Activity and Psychological Parameters in Women across a Broad Body Weight Spectrum

Suhs

Stengel

Rudolph

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…We further carried out a prospective study in newly diagnosed T2DM patients and found that spexin increased the most in the DM-OB group after the significant improvement of various metabolic indicators, especially body weight. Previous studies have also shown that plasma spexin levels increased at 3 months after laparoscopic sleeve gastrectomy in thirty adult individuals with obesity ( 20 ). Spexin levels significantly increased in individuals who responded to exercise (those with increased oxygen consumption) with a concomitant improvement in metabolic profile ( 12 ).…”

Section: Discussionmentioning

confidence: 84%

Serum spexin differed in newly diagnosed type 2 diabetes patients according to body mass index and increased with the improvement of metabolic status

Yan

Huang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveThe aim of this study was to explore serum spexin levels in newly diagnosed type 2 diabetes mellitus (T2DM) patients with different body mass indexes (BMIs) and to investigate the changes of spexin after improvement of metabolic indicators.MethodsA total of 323 newly diagnosed T2DM patients from national Metabolic Management Center (MMC) in Shanghai General Hospital were recruited. T2DM patients were categorized into three groups: diabetes with obesity group (DM-OB group, BMI≥28 kg/m2, n=89), diabetes with overweight group (DM-OV group, 24≤BMI<28 kg/m2, n=161), and diabetes with normal weight group (DM-NW group, 18≤BMI<24 kg/m2, n=73). In addition, 41 volunteers with normal glucose tolerance (NGT) were used as controls. Spexin and metabolic parameters were compared at baseline, and changes after MMC follow-up in 100 DM patients were investigated.ResultsIn the DM-OB group, the level of spexin was significantly lower than that in the DM-OV group and the DM-NW group (P < 0.01). Spexin was significantly negatively related to body mass index (BMI, β=-0.214, P<0.001), waist circumference (β=-0.249, P<0.001), visceral fat area (VFA, β=-0.214, P<0.001), and subcutaneous fat area (SFA, β=-0.265, P<0.001) after adjustment for age and sex. Among all the metabolic indicators, the decline in BMI in the DM-OB group was the most obvious among those in the three groups (-3.7 ± 0.8 kg/m2 vs. -0.9 ± 0.3 kg/m2 vs. 0.7 ± 0.6 kg/m2, P<0.01) after one year of MMC standardized management. The serum spexin level in the DM-OB group increased the most (1.00 ± 0.10 ng/mL vs. 0.49 ± 0.06 ng/mL in DM-OV group and 0.58 ± 0.09 ng/mL in DM-NW group, P < 0.001).ConclusionsSerum spexin differed in newly diagnosed T2DM patients according to BMI and was lowest in the DM-OB group. With the improvement of metabolic indicators, especially the decline in BMI, serum spexin increased significantly after MMC management.

show abstract

“…7 In contrast, serum SPX levels were increased after Roux-en-Y gastric bypass (RYGB) surgery and laparoscopic sleeve gastrectomy (LSG) up to 32% and 35%, respectively. 29,34…”

Section: Glucose and Lipid Metabolismmentioning

confidence: 99%

“…11 In addition, short-and long-term SPX treatment decreased body weight and body mass index (BMI) in rats treated with high-fructose and HFF diets. 10,19,[27][28][29]…”

Section: Body Weightmentioning

confidence: 99%

“…7 In contrast, serum SPX levels were increased after Roux-en-Y gastric bypass (RYGB) surgery and laparoscopic sleeve gastrectomy (LSG) up to 32% and 35%, respectively. 29,34 A recent study showed that glucose-treated pig pancreatic islets showed increased SPX secretion, and this increase was negatively correlated with insulin, since insulin inhibited SPX secretion. 35 Also SPX inhibited basal and insulin-stimulated glucose uptake and lipogenesis in mouse fibroblast (3T3-L1) cells and human adipocytes.…”

Section: Glucose and Lipid Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

Impact of spexin on metabolic diseases and inflammation: An updated minireview

Türkel

Memi

Yazgan

2022

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Spexin (SPX) is a 14 amino acid length peptide hormone which was discovered using bioinformatic tools. It is extensively expressed in central and peripheral tissues and secreted into circulation in response to metabolic stress. Recent studies revealed that SPX acts as a multifunctional peptide in various metabolic processes such as body weight, food intake, energy balance, glucose and lipid metabolism, lipid storage, salt–water balance, and arterial blood pressure. Endogenous SPX is sensitive to metabolic changes, and circulating levels of SPX have been shown to be reduced in chronic diseases such as obesity, diabetes, and insulin resistance. Moreover, in fish and rodent models, systemic SPX treatment has positive effects on metabolism including reduced food intake, fat mass, lipid accumulation, and inflammation, improved insulin sensitivity, energy expenditure, and organ functions which are underlying mechanisms in diseases. Taken together, these findings suggest that SPX is a potential drug target for the development of new pharmacological strategies to cure metabolic diseases. This review focuses on metabolo-protective properties of SPX and discusses novel insights into the biology and mechanism of SPX in the pathogenesis of diabetes, obesity, non-alcoholic fatty liver disease, metabolic syndrome, polycystic ovary syndrome, cardiovascular diseases, and kidney diseases, which are considerable global health problems.

show abstract

Short-term changes and correlations of plasma spexin, kisspeptin, and galanin levels after laparoscopic sleeve gastrectomy

Cited by 6 publications

References 42 publications

Circulating Spexin Is Associated with Body Mass Index and Fat Mass but Not with Physical Activity and Psychological Parameters in Women across a Broad Body Weight Spectrum

Circulating Spexin Is Associated with Body Mass Index and Fat Mass but Not with Physical Activity and Psychological Parameters in Women across a Broad Body Weight Spectrum

Serum spexin differed in newly diagnosed type 2 diabetes patients according to body mass index and increased with the improvement of metabolic status

Impact of spexin on metabolic diseases and inflammation: An updated minireview

Contact Info

Product

Resources

About