Short Term Changes in Dietary Fat Content and Metformin Treatment During Lactation Impact Milk Composition and Mammary Gland Morphology

Carlson, Zach; Hafner, Hannah; Habbal, Noura El; Harman, Emma; Liu, Stephanie; Botezatu, Nathalie; Alharastani, Masa; Rivet, Cecilia; Reynolds, Holly M.; Both, Nyahon; Sun, Haijing; Bridges, Dave; Gregg, Brigid

doi:10.1007/s10911-022-09512-y

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Lactational metformin has also been shown to reduce the weight of pups born to chow-fed mothers. However metformin could not rescue the lactational HFD-induced increase in body weight and adiposity [ 34 ]. Still, there is a lack of studies assessing the impact of maternal metformin exposure on offspring's brain physiology, thus highlighting the need for additional studies on this topic.…”

Section: Introductionmentioning

confidence: 99%

Developmental metformin exposure does not rescue physiological impairments derived from early exposure to altered maternal metabolic state in offspring mice

Cantacorps,

Zhu,

Yagoub

et al. 2024

Molecular Metabolism

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Section: Introductionmentioning

confidence: 99%

Developmental metformin exposure does not rescue physiological impairments derived from early exposure to altered maternal metabolic state in offspring mice

Cantacorps,

Zhu,

Yagoub

et al. 2024

Molecular Metabolism

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Sweet Spot Regulation of Maternal Metabolic Health and Nutrition on β-Cell Mass in the Offspring

Chung,

Wong,

Her

et al. 2024

Advances in Anatomy, Embryology and Cell Biology

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The Influence of Maternal High Fat Diet During Lactation on Offspring Hematopoietic Priming

Kim,

Varghese,

Sun

et al. 2023

Endocrinology

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Obesity and metabolic diseases are rising among women of reproductive age, increasing offspring metabolic risk. Maternal nutritional interventions during lactation present an opportunity to modify offspring outcomes. We previously demonstrated in mice that adult male offspring have metabolic impairments and increased adipose tissue macrophages (ATM) when dams are fed high fat diet (HFD) during the postnatal lactation window (HFD PN). We sought to understand the effect of HFD during lactation on early-life inflammation. HFD PN offspring were evaluated at postnatal day 16 to 19 for tissue weight and gene expression. Profiling of adipose tissue and bone marrow immune cells was conducted through lipidomics, in vitro myeloid colony forming unit assays, and flow cytometry. HFD PN mice had more visceral gonadal white adipose tissue (GWAT) and subcutaneous fat. Adipose tissue RNA sequencing demonstrated enrichment of inflammation, chemotaxis, and fatty acid metabolism and concordant changes in GWAT lipidomics. Bone marrow (BM) of both HFD PN male and female offspring had increased monocytes (CD45+Ly6G−CD11b+CD115+) and B cells (CD45+Ly6G−CD11b−CD19+). Similarly, serum from HFD PN offspring enhanced in vitro BM myeloid colonies in a toll-like receptor 4-dependent manner. We identified that male HFD PN offspring had increased GWAT pro-inflammatory CD11c+ ATMs (CD45+CD64+). Maternal exposure to HFD alters milk lipids enhancing adiposity and myeloid inflammation even in early life. Future studies are needed to understand the mechanisms driving this pro-inflammatory state of both BM and ATMs, the causes of the sexually dimorphic phenotypes, and the feasibility of intervening in this window to improve metabolic health.

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Short Term Changes in Dietary Fat Content and Metformin Treatment During Lactation Impact Milk Composition and Mammary Gland Morphology

Cited by 3 publications

References 41 publications

Developmental metformin exposure does not rescue physiological impairments derived from early exposure to altered maternal metabolic state in offspring mice

Developmental metformin exposure does not rescue physiological impairments derived from early exposure to altered maternal metabolic state in offspring mice

Sweet Spot Regulation of Maternal Metabolic Health and Nutrition on β-Cell Mass in the Offspring

The Influence of Maternal High Fat Diet During Lactation on Offspring Hematopoietic Priming

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