Short term exposure to titanium, aluminum and vanadium (Ti 6Al 4V) alloy powder drastically affects behavior and antioxidant metabolites in vital organs of male albino mice

Khadija, Ghulam; Saleem, Ayisha; Akhtar, Zafrin; Naqvi, Zahra; Gull, Maham; Masood, Mahnoor; Mukhtar, Sana; Batool, Momna; Saleem, Nida; Rasheed, Tahir; Nizam, Naira; Ibrahim, Ather

doi:10.1016/j.toxrep.2018.06.006

Cited by 44 publications

(19 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, permanent implants can cause "stress-shielding" leading to loss of bone under the plate or between bone and implant, thereby increasing the risk of refractures, designated as peri-prosthetic or peri-implant fractures [29,31]. Moreover, the FDA has already described possible metallic sensitivity or allergic reactions linked to Ti-based alloys, such as Ti-6Al-4V [66], and studies using vanadium have also shown adverse effects [67]. However, resorbable materials exhibit functional properties by supporting bone formation and in-growth on a molecular level.…”

Section: Implant Materialsmentioning

confidence: 99%

Animal Models in Orthopedic Research: The Proper Animal Model to Answer Fundamental Questions on Bone Healing Depending on Pathology and Implant Material

Sommer¹,

Hahn²,

Okutan³

et al. 2020

Animal Models in Medicine and Biology

View full text Add to dashboard Cite

Different species vary in bone metabolism, especially in modeling and remodeling of the bone. Human-related diseases with severe outcomes on bone, such as osteoporosis or osteoarthritis, are often reflected in animal models, which cannot adequately mimic the human situation. The pre-clinical investigation of implant materials in vivo complicates the search for the ideal animal model, especially when combining pathologic bone diseases and implant material. For instance, while alterations in trabecular bone architecture are investigated in female osteoporotic rats, rodents commonly lack cortical bone remodeling or secondary osteon formation. Small ruminants are commonly used to study long bone defects or orthopedic materials, due to their comparability to humans regarding body weight, bone size, and fracture healing. Nevertheless, there are important differences between human and ruminant models: plexiform cortical bone, seasonal bone loss, and stronger trabecular bone appear in sheep compared to humans. This chapter will summarize fundamental differences in bone quality between different animal models used for orthopedic and implant material research. Thus, choosing the ideal animal model to answer the proposed research question remains the key to guarantee a solid and excellent scientific study.

show abstract

Section: Implant Materialsmentioning

confidence: 99%

Animal Models in Orthopedic Research: The Proper Animal Model to Answer Fundamental Questions on Bone Healing Depending on Pathology and Implant Material

Sommer¹,

Hahn²,

Okutan³

et al. 2020

Animal Models in Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…The activity of i-species (a i ) can be obtained using the method of tangential intercepts when the Gibbs free energy of mixing values are known. The method of tangential intercepts can be used to Metals 2020, 10, 510 5 of 18 obtain the partial molar Gibbs free values of solutions according to Equation (11), and activity values are obtained from ∆G m i using Equation (12), where ∆G m i is the partial Gibbs free energy of mixing.…”

Section: Calculation Of Activitymentioning

confidence: 99%

“…CP-Ti is a material widely used in medical applications; however, when the application requires high strength, Ti-6AI-4V alloy is utilized [10]. Unfortunately, Al and V are cytotoxic elements possibly associated with Alzheimer's disease, neuropathy and osteomalacia [11][12][13]. Therefore, in recent decades, research in this area has been focused on the development of new Ti-based alloys with non-toxic elements to the human body.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Analysis of the Formation of FCC and BCC Solid Solutions of Ti-Based Ternary Alloys by Mechanical Alloying

Aguilar

Martínez

Tello

et al. 2020

Metals

View full text Add to dashboard Cite

A thermodynamic analysis of the synthesis of face-centred cubic (fcc) and body-centred cubic (bcc) solid solutions of Ti-based alloys produced by mechanical alloying was performed. Four Ti-based alloys were analysed: (i) Ti-13Ta-3Sn (at.%), (ii) Ti-30Nb-13Ta (at.%), (iii) Ti-20Nb-30Ta (wt. %) and (iv) Ti-33Nb-4Mn (at.%). The milled powders were characterized by X-ray diffraction, and the crystallite size and microstrain were determined using the Rietveld and Williamson-Hall methods. The Gibbs free energy of mixing for the formation of a solid solution of the three ternary systems (Ti-Ta-Sn, Ti-Nb-Ta and Ti-Nb-Mn) was calculated using an extended Miedema's model, applying the Materials Analysis Applying Thermodynamics (MAAT) software. The values of the activity of each component were determined by MAAT. It was found that increasing the density of crystalline defects, such as dislocations and crystallite boundaries, changed the solubility limit in these ternary systems. Therefore, at longer milling times, the Gibbs free energy increases, so there is a driving force to form solid solutions from elemental powders. Finally, there is agreement between experimental and thermodynamic data confirming the formation of solid solutions.Author Contributions: Conceptualization, C.A. and C.M.; methodology, C.A. and F.S.M.; software, C.A.; validation, I.A.; formal Analysis, C.A., C.M. and S.P.; investigation, C.A., F.S.M. and K.T.; writing-original draft preparation, C.A., S.P. and A.D.; writing-review and editing, S.P., A.D., K.T. and I.A.; visualisation, C.A. and I.A.; project administration, C.A.; funding acquisition, C.A. and K.T. All authors have read and agreed to the published version of the manuscript. Funding:The authors would like to acknowledge the financial support received from the FONDECYT project n 1190797 and FONDEQUIP/EQM project n 140095. Conflicts of Interest:The authors declare no conflict of interest.

show abstract

“…Researchers have attempted to improve the functional conditions of implants by changing their chemical composition. Other motivations behind these attempts have been to address the possible release of toxic and allergenic vanadium ions [5], the low wear resistance of Ti-6Al-4V [6], low oxidation and corrosion resistance [7]. This has led to the investigation of various V-free alloys as alternatives to conventional implants.…”

Section: Introductionmentioning

confidence: 99%

“…In the first attempts to establish the biocompatibility of γ-TiAl, an animal model was used to measure the biocompatibility of the Ti-48Al-2Cr-2Nb intermetallic compound and significant osseointegration and osteoconductivity were reported [10]. Ti-based implants have some amounts of aluminum (Al), which may exacerbate Alzheimer's disease and neuro-inflammation [5]. The high Al content in γ-TiAl alloy (33.34%) may be a source of concern in this regard, but given the intermetallic nature of this alloy, there is a strong bond between Al and Ti at the atomic level, which significantly reduces the likelihood of release of Al in the biological environment [11,12].…”

Section: Introductionmentioning

confidence: 99%

Advanced surface treatment techniques counteract biofilm-associated infections on dental implants

Koopaie

Bordbar‐Khiabani

Kolahdooz

et al. 2020

Mater. Res. Express

View full text Add to dashboard Cite

Topography and surface chemistry can significantly affect biofilm formation on dental implants. Recently, the γ-TiAl alloy was considered as the most reliable candidates for the preparation of dental implants because of its excellent mechanical strength, chemical stability and biocompatibility. The emphasis of this study lies in the effects of high-speed milling assisted the minimum quantity of lubrication (HSM-MQL), micro-current wire electrical discharge machining (mWEDM), Er,Cr:YSGG laser and sandblasting/largegrit/acid-etching (SLA) treatments on surface morphology, topography, chemical composition, wettability and biofilm-associated infections on the surface of each group. The surface-treated samples were analyzed using a scanning electron microscope (SEM), SEM surface reconstruction, energy dispersive x-ray spectroscopy (EDS) and water contact angle measuring system. SEM and topography images of mWEDM and laser-treated surfaces showed more irregular surfaces compared to SLA and HSM-MQL surfaces. Results showed that mWEDM and laser-treated surfaces revealed hydrophobic behavior. A significant decrease of biofilm formation was observed on mWEDM treated surface due to the hydrophobicity and existence of the copper element in the recast layer chemical composition. Moreover, EDS confirmed that the zirconium, silicon, and fluorine elements were decorated onto the SLA treated γ-TiAl surface that can have a direct effect on the anti-bacterial activity.

show abstract

Short term exposure to titanium, aluminum and vanadium (Ti 6Al 4V) alloy powder drastically affects behavior and antioxidant metabolites in vital organs of male albino mice

Abstract: Graphical abstract

Cited by 44 publications

References 29 publications

Animal Models in Orthopedic Research: The Proper Animal Model to Answer Fundamental Questions on Bone Healing Depending on Pathology and Implant Material

Animal Models in Orthopedic Research: The Proper Animal Model to Answer Fundamental Questions on Bone Healing Depending on Pathology and Implant Material

Thermodynamic Analysis of the Formation of FCC and BCC Solid Solutions of Ti-Based Ternary Alloys by Mechanical Alloying

Advanced surface treatment techniques counteract biofilm-associated infections on dental implants

Contact Info

Product

Resources

About