Short-Term Outcomes for the Biologic Treatment of Bone Marrow Edema of the Knee Using Bone Marrow Aspirate Concentrate and Injectable Demineralized Bone Matrix

Kasik, Connor; Martinkovich, Stephen; Mosier, Brian; Akhavan, Sam

doi:10.1016/j.asmr.2019.07.001

Cited by 17 publications

(9 citation statements)

References 43 publications

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“…The IOBP has been shown to provide pain relief in the short term by using BMAC and DBM as an adjunct to arthroscopy for treating BML associated with degenerative conditions of the knee. 16 The IOBP procedure is the biologic treatment of bone marrow lesions with techniques that encourage physiologic remodeling and repair of the subchondral bone defects by performing a core decompression of the lesion and a direct application of BMAC mixed with DBM into the defect under fluoroscopic guidance. 15 , 16 This procedure targets and fills subchondral bone defects in patients who have not responded to conservative treatment.…”

Section: Discussionmentioning

confidence: 99%

“… 16 The IOBP procedure is the biologic treatment of bone marrow lesions with techniques that encourage physiologic remodeling and repair of the subchondral bone defects by performing a core decompression of the lesion and a direct application of BMAC mixed with DBM into the defect under fluoroscopic guidance. 15 , 16 This procedure targets and fills subchondral bone defects in patients who have not responded to conservative treatment. The PRP-DBM injection has osteogenic potential to promote bone production and fill the void left from decompression.…”

Section: Discussionmentioning

confidence: 99%

“…Intraosseous bioplasty (IOBP), was first described for arthroscopic-assisted treatment of subchondral bone cysts in the proximal tibia for the early stages of knee OA. 15 , 16 This technique entails combining bone marrow aspirate concentrate (BMAC) or concentrated platelet-rich plasma (cPRP) with demineralized bone matrix (DBM) as a bone substitute before injecting it into subchondral bone defects under fluoroscopic guidance. IOBP of the hip, in particular the acetabulum, when done using this technique is a useful alternative that can be beneficial in treating young patients with early hip arthritis to achieve successful outcomes while delaying more invasive procedures.…”

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confidence: 99%

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Arthroscopic-Assisted Intraosseous Bioplasty of the Acetabulum

Ankem

Diulus

Maldonado

et al. 2020

Arthroscopy Techniques

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Intraosseous bioplasty (IOBP), has been previously described for arthroscopic-assisted treatment of subchondral bone cysts in the proximal tibia associated with early stages of knee osteoarthritis (OA). This technique entails combining bone marrow aspirate concentrate or concentrated platelet-rich plasma with demineralized bone matrix as a bone substitute before injecting into a subchondral bone defect under fluoroscopic guidance. The principles of IOBP as a procedure that combines core decompression with biologic bone substitute augmentation can be extended to treat subchondral bone marrow lesions such as acetabular and femoral cysts in degenerative hip OA. Intraosseous bioplasty of the hip, in particular the acetabulum, when done using this technique, is a useful alternative that can be beneficial in treating young patients with early hip arthritis to achieve successful outcomes while delaying more invasive procedures. The Technical Note described here presents a step-by-step approach, including tips and pearls for arthroscopic-assisted IOBP with decompression of the subchondral cyst in the acetabulum followed by bone substitute injection under fluoroscopic guidance. We believe this method is a safe and reproducible way to treat subchondral defects in young patients with signs of early osteoarthritis of the hip joint.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Arthroscopic-Assisted Intraosseous Bioplasty of the Acetabulum

Ankem

Diulus

Maldonado

et al. 2020

Arthroscopy Techniques

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“…В одной из работ изучали результаты лечения ОКМ коленного сустава методом введения аспирата костного мозга (bone marrow aspirate concentrate, BMAC) и инъекции деминерализованного костного матрикса (injectable demineralized bone matrix, iDBM). Авторы сообщили, что лечение с использованием BMAC и iDBM является эффективным дополнением к артроскопии, обеспечивая снижение болевого синдрома в краткосрочном периоде наблюдения [47].…”

Section: лечениеunclassified

Bone marrow edema in terms of joint pathology

Airapetov¹,

Воротников²,

Васюков³

2020

Innovacionnaâ medicina Kubani

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New possibilities of modern medical science open up prospects for instrumental and laboratory diagnostics of many pathological conditions, unknown or not previously diagnosed in the practice of an orthopedist. These include bone marrow edema. Not only orthopedic traumatologists, but also rheumatologists, neurosurgeons, general practitioners, rehabilitation therapists, morphologists, and many others today face this concept in a variety of definitions, concepts of etiology, pathogenesis, and clinical recommendations for treatment.The authors performed a systematic review by using four open resources: electronic scientific library (elibrary), PubMed, SciVerse (Science Direct), and Scopus.The complexity of pathology lies in the fact that in each specific case, the development of treatment tactics requires a personal interpretation of the entire variety of data obtained and a case by case approach.

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“…The presence of BML has been strongly associated with osteoarthritis pathogenesis and pain in knee osteoarthritis [ 2 ]. Therefore, the subchondral BMLs have been considered as one of the treatment targets in knee osteoarthritis patients and recent studies have shown a positive therapeutic effect with intraosseous platelet-rich plasma (PRP) or bone marrow aspirate concentrate injections [ 1 , 3 ]. The traditional intraosseous injection is performed by using a large caliber trocar under fluoroscopy.…”

Section: Introductionmentioning

confidence: 99%