Short term results from GHRH analogue use in pre-menopausal breast cancer in Korea

Kim, H.J.; Lee, Joong Sun; Park, E.H.; Lim, Weon Jeong; Sei, Jungetsu; Koh, Beom Seok; Son, Byung Ho; Ahn, Junseong; Jeong, Kyung-Yi; Kim, S.B.

doi:10.1016/j.ejso.2009.01.016

Cited by 7 publications

(12 citation statements)

References 13 publications

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“…Similar to other studies comparing the efficacies of GnRH agonist and chemotherapy in premenopausal breast cancer patients [13,14], our patients in the GnRHa+T group showed comparable treatment outcomes to those in the AC->T group.…”

Section: Discussionsupporting

confidence: 88%

“…The Zoladex Early Bresat Cancer Research Association, ZEBRA) trial [6,15] and International Breast Cancer Study Group (IBCSG) VIII [16] trials found similar efficacy for GnRH agonist and cyclophosphamide, methotrexate, 5-fluorouracil chemotherapy chemotherapy in terms of RFS and OS in hormone-responsive early breast cancer. Kim et al [14] compared the efficacies of GnRHa+T and AC->T with a median follow-up period of 30 months. Although that was a small, preliminary study with a relatively short follow-up period, the authors concluded that GnRHa+T can be an alternative treatment option in premenopausal patients with endocrine-responsive, N0 breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…In their 7-year follow-up of the French Adjuvant Study Group 06 randomized trial, Roche et al [13] reported that combining GnRH agonist and tamoxifen (GnRHa+T) and epirubicin-based chemotherapy without hormonal therapy showed similar 7-year disease-free survival and overall survival (OS) rates in premenopausal patients with N1, early breast cancer. Similarly, Kim et al [14] concluded that GnRHa+T can be an alternative treatment option to sequential adriamycin and cyclophosphamide (AC) chemotherapy and tamoxifen (AC->T) in premenopausal patients with hormone receptor-positive, hormone-responsive, lymph-node–negative (N0) breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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Survival Outcome of Combined GnRH Agonist and Tamoxifen Is Comparable to That of Sequential Adriamycin and Cyclophosphamide Chemotherapy Plus Tamoxifen in Premenopausal Patients with Lymph-Node–Negative, Hormone-Responsive, HER2-Negative, T1-T2 Breast Cancer

et al. 2016

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PurposeThe purpose of this study was to compare treatment outcomes between combined gonadotropin-releasing hormone agonist and tamoxifen (GnRHa+T) and sequential adriamycin and cyclophosphamide chemotherapy and tamoxifen (AC->T) in premenopausal patients with hormone-responsive, lymph-node–negative breast cancer.Materials and MethodsIn total, 994 premenopausal women with T1-T2, lymph-node–negative, hormone-receptor-positive, HER2-negative breast cancer between January 2003 and December 2008 were included in this retrospective cohort study. GnRHa+T and AC->T were administered to 608 patients (61.2%) and 386 patients (38.8%), respectively. Propensity score matching and inverse probability weighting were applied to the original cohort, and 260 patients for each treatment arm were included in the final analysis. Recurrence-free, cancer-specific, and overall survival was compared between the two treatment groups.ResultsA total of 994 patients were followed up for a median of 7.4 years (range, 0.5 to 11.4 years). The 5-year follow-up rate was 98.7%, and 13 patients were lost to follow-up. In propensity-matched cohorts (n=520), there was no difference in recurrence-free, cancer-specific, and overall survival rates between the two treatment groups (p=0.306, p=0.212, and p=0.102, respectively), and this was maintained after applying inverse probability weighting.ConclusionGnRHa+T is a reasonable alternative to AC->T in patients with premenopausal, hormone-responsive, HER2-negative, lymph-node–negative, T1-T2 breast cancer.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Survival Outcome of Combined GnRH Agonist and Tamoxifen Is Comparable to That of Sequential Adriamycin and Cyclophosphamide Chemotherapy Plus Tamoxifen in Premenopausal Patients with Lymph-Node–Negative, Hormone-Responsive, HER2-Negative, T1-T2 Breast Cancer

et al. 2016

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“…To the best of our knowledge, at present, there is no randomised controlled trial that compared combined ovarian function suppression and TAM with sequential AC-TAM. The present retrospective study found comparable survival outcome between these two treatment regimens similar to other previous retrospective studies of a Korean population (39,40). There was only one local recurrence in the GnRH-TAM group while in the AC-TAM group, 2 patients with distant metastasis were identified.…”

Section: Discussionsupporting

confidence: 88%

Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer

et al. 2019

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Survival outcome of ovarian suppression plus tamoxifen has been shown to be comparable with chemotherapy in premenopausal women; however, there are a few previous studies that compared this treatment to the current standard adriamycin and cyclophosphamide (AC) regimen. The aim of the present study was to compare the survival outcome of gonadotropin-releasing hormone (GnRH) agonist plus tamoxifen (GnRH-TAM) and chemotherapy AC plus tamoxifen (AC-TAM) in premenopausal patients with early breast cancer who were hormone receptor-positive. Premenopausal patients with early breast cancer who were treated at The Siriraj Hospital between January 2005 and December 2015 were retrospectively recruited. The inclusion criteria included newly diagnosed breast cancer, size ≤3 cm, node-negative and hormone receptor-positive. All patients received adjuvant systemic therapy and were divided into two groups. In the GnRH-TAM group, the patients received subcutaneous injection of 10.8 mg of goserelin every 3 months for 2-3 years and TAM (20 mg/day) for 5 years. In the AC-TAM group, AC was administered every 3 weeks for 4 cycles followed by TAM (20 mg/day) for 5 years. In total, 40 patients received GnRH-TAM and 130 patients received AC-TAM. The mean age at diagnosis was 44.4±6.3 years while the median follow up time was 77 (36-167) months. There was no mortality in either group and no significant difference in disease-free survival between the two groups. No adverse effect occurred and good compliance was observed in all patients who received GnRH-TAM. Treatment with GnRH-TAM resulted in a comparable survival outcome and better quality of life compared with AC-TAM.

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“…Particularly, inhibition of estradiol (E2) production is the basis of treatment in premenopausal women, and various methods of suppressing the ovarian function, such as ovarian ablation, have been implemented [ 5 ]. In several clinical studies, luteinizing hormone-releasing hormone analogs (LHRHa) are used as an adjuvant therapy after surgery in patients with HR(+), human epidermal growth factor receptor 2 negative (−), and lymph node (+/−) breast cancer, and they are considered a replacement for chemotherapy (CTx) by exerting the same effect as CTx, but with fewer side effects [ 7 8 9 10 11 ]. In clinical studies involving patients with breast cancer, LHRHa is mainly administered as a 1-month regimen (3.75 mg leuprolide, 3.6 mg goserelin, and 3.75 mg triptorelin); therefore, a 1-month formulation is recommended in the guidelines [ 2 3 4 ].…”

mentioning

confidence: 99%

Change in Estradiol Levels among Premenopausal Patients with Breast Cancer Treated Using Leuprolide Acetate 11.25 Milligrams 3-Month Depot and Tamoxifen

Lee

Kim

et al. 2020

J Breast Cancer

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The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages in terms of patient convenience. However, data on the effectiveness of the 3-month (3M) acting formulation are still insufficient. This study was performed on patients who received the 3M LHRHa after surgery. The serum estradiol (E2) and follicle-stimulating hormone levels were measured before surgery, and periodically after surgery. In total, 318 patients were included in the study and analyzed. The mean E2 level before surgery was 63.7 pg/mL, while the mean E2 level during the administration of 3M LHRHa was 4.9 pg/mL. None of the patients were menstruating and had E2 values above 30.0 pg/mL. It is thought that the 3M LHRHa formulation can suppress the ovarian function effectively and be safely used to improve compliance.

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Short term results from GHRH analogue use in pre-menopausal breast cancer in Korea

Cited by 7 publications

References 13 publications

Survival Outcome of Combined GnRH Agonist and Tamoxifen Is Comparable to That of Sequential Adriamycin and Cyclophosphamide Chemotherapy Plus Tamoxifen in Premenopausal Patients with Lymph-Node–Negative, Hormone-Responsive, HER2-Negative, T1-T2 Breast Cancer

Survival Outcome of Combined GnRH Agonist and Tamoxifen Is Comparable to That of Sequential Adriamycin and Cyclophosphamide Chemotherapy Plus Tamoxifen in Premenopausal Patients with Lymph-Node–Negative, Hormone-Responsive, HER2-Negative, T1-T2 Breast Cancer

Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer

Change in Estradiol Levels among Premenopausal Patients with Breast Cancer Treated Using Leuprolide Acetate 11.25 Milligrams 3-Month Depot and Tamoxifen

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