Short-term symptomatic and functional outcomes of schizophrenia in Butajira, Ethiopia

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

“…Participants included males and females with a mean age of participants with a schizophrenia spectrum disorder, reported in 21 of the 33 studies, ranging between 20.3 and 57.9 years. 48,68,[70][71][72][73][75][76][77][78][79][80]82,84,86,[88][89][90][91]94,95 All studies obtained HRQoL information from patients; seven of these studies compared patient HRQoL values with published general population 'normative' values, [70][71][72][73][74][75][76] three compared HRQoL values with normal comparison participants that were recruited to the study [77][78][79] and two used 'norms' from healthy participants who had taken part in large surveys.…”

“…83 Four studies investigated differences in HRQoL between mood groups in bipolar disorder. 75,[84][85][86] Two of the four studies investigating the EQ-5D used general population preferences for EQ-5D health states to generate EQ-5D index values. 87,96 Personality disorder…”

“…66,67,[69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85]88,[92][93][94][95] Although there appears to be strong evidence that the SF-36 is able to distinguish between general population norms and scores of people with schizophrenia (known-group validity), the evidence for convergent validity and responsiveness is less certain ( Table 4). Similar findings exist for the EQ-5D, with mixed evidence for the properties of convergent validity and responsiveness.…”

Cost-effectiveness of the Mental Health and Development model for schizophrenia-spectrum and bipolar disorders in rural Kenya

“…Comparison results were drawn from the literature, outside the primary setting. We reviewed prospective and retrospective cohort studies of the natural course of schizophrenia and bipolar disorder from low-income countries (Thirthalli et al, 2009, Haro et al, 2011, Ran et al, 2001) and selected one from Ethiopia (Kebede et al, 2005) for being closest in context.…”

“…In the absence of a local comparison group, 'usual care' was characterized by obtaining evidence from the literature, using a prospective cohort study from rural Ethiopia (Kebede et al, 2005), observing the natural course of 307 individuals with schizophrenia over four years. At baseline, 89% of the sample were treatment-naïve, and at follow-up patients had received a "first-generation" neuroleptic 28% of the intervening time.…”