Short‐term venom immunotherapy induces desensitization of Fcε<scp>RI</scp>‐mediated basophil response

Čelesnik, Nina; Vesel, Tina; Rijavec, Matija; Šilar, Mira; Eržen, Renato; Košnik, Mitja; Zitnik, Simona Eva; Avčin, Tadej; Korošec, Peter

doi:10.1111/all.12044

Cited by 28 publications

(43 citation statements)

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“…Ultra-rush and semi-rush AIT is associated with a similar anergy of basophils (4,11) and with a change in basophil sensitivity. We have not measured effect on basophil sensitivity after desensitization, but noted that the point of inflection of the baseline response in blood was comparable to the sensitivity of basophils before treatment, suggesting that sensitivity did not change during our desensitization protocol.…”

Section: Discussionmentioning

confidence: 94%

“…The mechanism behind AIT is not fully understood, but involves blocking IgG antibodies, a skewing from a Th2 towards a Th1 response and increased number and activity of regulatory T cells (1)(2)(3). This happens after weeks of treatment, yet an effect can already be seen after a few days of 'rush up-dosing' (4,5). Desensitization is proposed to contribute to this early tolerance (2,3).…”

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confidence: 99%

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Sequential allergen desensitization of basophils is non‐specific and may involve p38 MAPK

Christensen

Krohn

Thuraiaiyah

et al. 2014

Allergy

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

Sequential allergen desensitization of basophils is non‐specific and may involve p38 MAPK

Christensen

Krohn

Thuraiaiyah

et al. 2014

Allergy

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“…Short-term venom immunotherapy induces desensitization of FcεRI-mediated basophil response. The levels of mRNA and FcεRI cell-surface expression decreased in basophil cells from patients submitted to venom immunotherapy, indicating that the reduction in FcεRI expression contributes to the phenomenon of the early basophil desensitization observed after AIT [37,38]. On the other hand, AIT also provokes an allergen-mediated upregulation of the type 2 histamine receptor (H2R) gene, which was associated with the suppression of FcεRI-mediated basophil activation, inducing a tolerogenic response (Figure 2) [34,39].…”

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Taketomi¹,

Miranda²,

Júnior³

et al. 2017

Immunotherapy - Myths, Reality, Ideas, Future

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The clinical efficacy of the allergen-specific immunotherapy (AIT) has been well-documented using inhalant or hymenoptera-derived allergens in atopic patients with corresponding specific IgE antibodies. AIT is considered as the unique treatment that is capable of modifying the natural course of the allergic disease because it induces a variety of immunological mechanisms, with emphasis in the production of blocking IgG antibodies by IL-10-stimulated B cells due to the generation of Treg, Breg, or even Th2 cells. Thus, the measurement of specific IgG subclasses, particularly IgG4, to the crude extract or more importantly to allergen components, might be a useful and potential tool to follow-up objectively the patients undergoing AIT in addition to clinical parameters. In this chapter, the authors have emphasized a very sensitive and highly specific reverse ELISA, developed by them, to measure IgG subclasses directed to clinically relevant natural allergens that are undoubtedly better when compared to those obtained with recombinant counterparts. Such a technique may produce more authentic results taking into account the IgG subclass binding capacity to a particular allergen and might be a valuable and alternative method for monitoring activation of tolerance-inducing mechanisms in patients under AIT.

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“…Basophil sensitivity is reduced unspecifically during rush immunotherapy [77], in a process that can be reproduced ex vivo [52]. Basophil sensitivity reflected an increase in the protection afforded by subcutaneous immunotherapy (SCIT) with insect venom after 6 weeks and 1 year of treatment [78].…”

Section: Exploring the Mechanism Of Ait With Basophil Activationmentioning

confidence: 99%

News in Cellular Allergology: A Review of the Human Mast Cell and Basophil Granulocyte Literature from January 2013 to May 2015

Hoffmann

2015

Int Arch Allergy Immunol

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Mast cell activation releases the mediators associated with type I allergy. As such, the study of mast cell activation is critical for understanding the allergic reaction, and for developing methods to control it. Importantly, another ligand receptor pair (compound 48/80 and MRGPRX2) that activates mast cells in addition to allergen-IgE-FcεRI has been identified. As mast cells mature in tissue from hematopoietic stem cells, their physiology and pathophysiology is difficult to study. Mast cell lines and mast cells cultured from stem cells are often studied instead of tissue mast cells. There has been some progress in the description of the mechanism of the activation of mast cells, substances limiting mast cell activation and in the catalogue of proteases that mast cells express. Basophil granulocytes express FcεRI, bind IgE and respond to allergen crosslinking in a very similar fashion to mast cells. In the recent literature, basophils were mistakenly described as antigen-presenting cells; this has convincingly been disputed in a number of subsequent publications. Their function in physiology and pathophysiology is not known, but they are frequently used to document allergic sensitisation in the basophil activation test. Significant progress has been made in documenting the relevance of basophil activation as a second-line test in allergy diagnosis. Basophil reactivity and sensitivity may reflect symptom severity and allergen threshold, and are used to document and monitor allergy. The physiology and pathophysiology of allergic effector cells remain an important area of research.

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Short‐term venom immunotherapy induces desensitization of FcεRI‐mediated basophil response

Abstract: We found a marked desensitization of FcεRI-activated basophils after short-term VIT. This suppression, which could be highly relevant for the development of early protective mechanisms, might be also related to the changes at the level of FcεRI expression.

Cited by 28 publications

References 28 publications

Sequential allergen desensitization of basophils is non‐specific and may involve p38 MAPK

Sequential allergen desensitization of basophils is non‐specific and may involve p38 MAPK

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

News in Cellular Allergology: A Review of the Human Mast Cell and Basophil Granulocyte Literature from January 2013 to May 2015

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