Short-term vitamin D supplementation improves hepatic steatosis as quantified by controlled attenuation parameter (CAP)

Papapostoli, Ifigeneia; Lammert, Frank; Stokes, Caroline S.

doi:10.1055/s-0035-1559106

Cited by 1 publication

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“…Our findings regarding the relationship between vitamin D deficiency and NAFLD suggest that taking vitamin D supplements represents a therapeutic option for patients with NAFLD. Hepatic steatosis severity was found to significantly improve after four weeks of vitamin D supplementation [40]. Additional studies are required to determine the therapeutic effects of vitamin D supplementation on NAFLD in adolescents.…”

Section: Discussionmentioning

confidence: 99%

Association Between Vitamin D Deficiency and Suspected Nonalcoholic Fatty Liver Disease in an Adolescent Population

Cho

Kim

Shim

et al. 2019

Pediatr Gastroenterol Hepatol Nutr

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Purpose Vitamin D deficiency is a condition widespread throughout the world. Recent studies have suggested that vitamin D deficiency was associated with obesity and metabolic syndrome. The purpose of the study was to examine the relationship between vitamin D deficiency and nonalcoholic fatty liver disease (NAFLD) in adolescents. Methods The data were obtained from the Korean National Health and Nutrition Examination Survey from 2008–2014. A total of 3,878 adolescents were included in the study. Vitamin D deficiency was defined as a 25-hydroxyvitamin D concentration <20 ng/mL and suspected NAFLD was defined as an alanine transaminase concentration >30 U/L. Results Vitamin D deficiency was noted in 78.9% of the studied population. Age, body mass index, waist circumference, and blood pressure, glucose, cholesterol, and triglyceride levels were significantly higher in adolescents with suspected NAFLD than in adolescents without suspected NAFLD, while the mean vitamin D level was significantly lower in adolescents with suspected NAFLD. The multivariate-adjusted odds of suspected NAFLD were higher with increased age, male gender, obesity, and metabolic syndrome. Individuals with vitamin D deficiency were at higher risk of suspected NAFLD (odds ratio, 1.77; 95% confidence interval, 1.07–2.95) after adjusting for age, gender, obesity, and metabolic syndrome. Conclusion Vitamin D deficiency was associated with suspected NAFLD, independent of obesity and metabolic syndrome, in adolescents.

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Section: Discussionmentioning

confidence: 99%