Short-term vitamin E supplementation before marathon running: a placebo-controlled trial

Buchman, Alan L.; Killip, Donna; Ou, Ching Nan; Rognerud, Cheryl L.; Pownall, Henry J.; Dennis, K. J.; Dunn, Jon D.

doi:10.1016/s0899-9007(99)00005-2

Cited by 33 publications

(28 citation statements)

References 37 publications

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“…Long distance exercise effects gastric and intestinal mucosa integrity following a splanchnic circulation shunt (Oktedalen et al . 1992; Buchman et al . 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Endurance exercising is comparable to human athletes running marathons,where a prevalence of 54% of gastrointestinal signs has been reported (bleeding, abdominal cramping, nausea and diarrhoea) (Halvorsen et al 1986). Long distance exercise effects gastric and intestinal mucosa integrity following a splanchnic circulation shunt (Oktedalen et al 1992;Buchman et al 1999). A similar pathogenesis of ischaemic enteropathy could be involved in the endurance horses.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of gastric ulcer syndrome in high-level endurance horses

Tamzali

Marguet

Priymenko

et al. 2011

Equine Veterinary Journal

110

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“…Long distance exercise effects gastric and intestinal mucosa integrity following a splanchnic circulation shunt (Oktedalen et al . 1992; Buchman et al . 1999).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of gastric ulcer syndrome in high-level endurance horses

Tamzali

Marguet

Priymenko

et al. 2011

Equine Veterinary Journal

110

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“…Plasma a-tocopherol concentrations increase following exercise, and can rise up to three-to four-fold approximately, regardless of duration, dose or frequency of supplementation (Buchman et al, 1998;Traber, 1999;Mastaloudis et al, 2004). Accordingly, our results showed no significant differences between supplemented and nonsupplemented sportsmen, probably due to the low vitamin E supplementation (the used enriched beverage was designed just to cover approximately 30% RDI), and also because the half-marathon is an endurance physical activity of intensity lower than other strenuous exercises like a duathlon or an ultramarathon.…”

Section: Discussionmentioning

confidence: 99%

Differential response of plasma and immune cell's vitamin E levels to physical activity and antioxidant vitamin supplementation

et al. 2005

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Objective: To assess the differential response of plasma, lymphocyte and neutrophil vitamin E levels to high-intensity physical activity and to vitamin C and E supplementation. Subjects: In all, 14 male trained amateur runners (32-36 y old) were randomly divided in two groups (supplemented and placebo), and participated in a half marathon race. The subjects did not take any other supplements than the ones provided for this study. Intervention: Vitamin C (152 mg/day) and E (50 mg/day) supplementation was administrated to athletes for a month, using a new almond-based isotonic and energetic beverage (supplemented group). The usual dietary habits of participants were assessed using a self-reported 7-day 24-h recall before the day of the study. To avoid the beverage influence, nonenriched vitamin C and E almond-based isotonic and energetic beverage was given to the placebo group. After 1 month, subjects participated in a half marathon race (21 km run). Vitamin E concentration was determined in plasma, neutrophils and lymphocytes before and immediately after the race, and 3 h after finishing the race. Results: Daily energy intake and caloric profile of supplemented and placebo group were not different except for vitamin C and E supplementation. Vitamin supplementation and exercise had no effect on vitamins E levels in plasma. The exercise significantly (Po0.05) increased the lymphocyte vitamin E concentration both in the placebo ( þ 119%) and supplemented groups ( þ 128%), and neutrophil vitamin E content in the supplemented group ( þ 88%). These levels remained significantly (Po0.05) high after the short recovery. After exercise, vitamin E levels in lymphocytes and neutrophils of supplemented subjects were practically twice the levels before exercise, whereas neutrophil vitamin E content of the placebo group was close to those in plasma. Conclusion: After endurance exercise, lymphocytes increased their vitamin E content in the supplemented and placebo subjects whereas this trend in neutrophils was just observed in the supplemented group. The determination of vitamin E content in lymphocytes and neutrophils after exercise is a useful tool to assess the functional status of vitamin E.

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“…Dual‐sugar tests have been used to determine exercise‐associated changes in intestinal permeability; lactulose with rhamnose or mannitol is used for small intestine, sucralose and erythritol for large intestine, and sucrose for gastric permeability . As outlined in Table (seven studies were eligible for inclusion Table S1), gastrointestinal permeability appears to increase in proportion to the magnitude of exercise, with higher body temperature and running linked with greater permeability . For example, marathon competition and running at ≥70% VO 2max , with or without heat stress, with body temperature ≥39°C, resulted in the highest reported rates of elevated small intestinal permeability .…”

Section: Exercise and Intestinal Permeabilitymentioning

confidence: 99%

Systematic review: exercise‐induced gastrointestinal syndrome—implications for health and intestinal disease

Costa

Snipe

Kitic

et al. 2017

Aliment Pharmacol Ther

296

426

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Summary Background “Exercise‐induced gastrointestinal syndrome” refers to disturbances of gastrointestinal integrity and function that are common features of strenuous exercise. Aim To systematically review the literature to establish the impact of acute exercise on markers of gastrointestinal integrity and function in healthy populations and those with chronic gastrointestinal conditions. Methods Search literature using five databases (PubMed, EBSCO, Web of Science, SPORTSdiscus, and Ovid Medline) to review publications that focused on the impact of acute exercise on markers of gastrointestinal injury, permeability, endotoxaemia, motility and malabsorption in healthy populations and populations with gastrointestinal diseases/disorders. Results As exercise intensity and duration increases, there is considerable evidence for increases in indices of intestinal injury, permeability and endotoxaemia, together with impairment of gastric emptying, slowing of small intestinal transit and malabsorption. The addition of heat stress and running mode appears to exacerbate these markers of gastrointestinal disturbance. Exercise stress of ≥2 hours at 60% VO2max appears to be the threshold whereby significant gastrointestinal perturbations manifest, irrespective of fitness status. Gastrointestinal symptoms, referable to upper‐ and lower‐gastrointestinal tract, are common and a limiting factor in prolonged strenuous exercise. While there is evidence for health benefits of moderate exercise in patients with inflammatory bowel disease or functional gastrointestinal disorders, the safety of more strenuous exercise has not been established. Conclusions Strenuous exercise has a major reversible impact on gastrointestinal integrity and function of healthy populations. The safety and health implications of prolonged strenuous exercise in patients with chronic gastrointestinal diseases/disorders, while hypothetically worrying, has not been elucidated and requires further investigation.

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Short-term vitamin E supplementation before marathon running: a placebo-controlled trial

Cited by 33 publications

References 37 publications

Prevalence of gastric ulcer syndrome in high-level endurance horses

Prevalence of gastric ulcer syndrome in high-level endurance horses

Differential response of plasma and immune cell's vitamin E levels to physical activity and antioxidant vitamin supplementation

Systematic review: exercise‐induced gastrointestinal syndrome—implications for health and intestinal disease

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