Shortened telomere length in peripheral blood leukocytes of patients with lung cancer, chronic obstructive pulmonary disease in a high indoor air pollution region in China

Xue, Yanfeng; Guo, Xiaoran; Huang, Xinwei; Zhu, Zongxin; Chen, Ming‐Hui; Chu, Jiang; Yang, Guixian; Wang, Qiang; Kong, Xiangyang

doi:10.1016/j.mrgentox.2020.503250

Cited by 11 publications

(13 citation statements)

References 40 publications

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“…First, AF causes a decrease in cardiac output of approximately 25%, affecting activity tolerance and frailty indices, which may accelerate systemic telomere shortening ( 41 , 42 ). Second, the thrombosis and hemodynamic abnormalities induced by AF cause damage to other organs, such as the lungs and kidneys, and the reduction in the function of these organs can also result in telomere attrition ( 43 – 45 ). Third, animal experiments have also shown that atrial fibrillation leads to the accumulation of reactive oxygen species and elevated levels of inflammation, which are also potential factors for DNA and telomere damage ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between atrial fibrillation and leukocyte telomere length: A two sample, bidirectional Mendelian randomization study

Sha

Hou²,

Zhou³

et al. 2023

Front. Cardiovasc. Med.

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BackgroundAtrial fibrillation (AF) is an age-related disease, while telomeres play a central role in aging. But the relationship between AF and telomere length (LTL) is still controversial. This study aims to examine the potential causal association between AF and LTL by using Mendelian randomization (MR).MethodsBidirectional two-sample MR, expression and protein quantitative trait loci (eQTL and pQTL)-based MR were performed using genetic variants from United Kingdom Biobank, FinnGen, and a meta-analysis study, which comprised nearly 1 million participants in the Atrial Fibrillation Study and 470,000 participants in the Telomere Length Study. Apart from the inverse variance weighted (IVW) approach as the main MR analysis, complementary analysis approaches and sensitivity analysis were applied.ResultsThe forward MR revealed a significant causal estimate for the genetically predicted AF with LTL shortening [IVW: odds ratio (OR) = 0.989, p = 0.007; eQTL-IVW: OR = 0.988, p = 0.005; pQTL-IVW: OR = 0.975, p < 0.005]. But in the reverse MR analysis, genetically predicted LTL has no significant correlation with AF (IVW: OR = 0.995, p = 0.916; eQTL-IVW: OR = 0.999, p = 0.995; pQTL-IVW: OR = 1.055, p = 0.570). The FinnGen replication data yielded similar findings. Sensitivity analysis ensured the stability of the results.ConclusionThe presence of AF leads to LTL shortening rather than the other way around. Aggressive intervention for AF may delay the telomere attrition.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between atrial fibrillation and leukocyte telomere length: A two sample, bidirectional Mendelian randomization study

Sha

Hou²,

Zhou³

et al. 2023

Front. Cardiovasc. Med.

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“…Furthermore, Kachuri et al ( 42 ) determined an association between mortality and shorter telomere length in no-smoker cohorts of patients with non-small cell lung cancer (NSCLC) and adenocarcinoma. In a Chinese region characterized by high indoor pollution, a shorter telomere length was detected in the peripheral blood leukocytes of patients with lung cancer and chronic obstructive pulmonary disease ( 43 ). The association was attributed to the high levels of oxidative stress and inflammation in the airways and blood of patients ( 43 ).…”

Section: Respiratory Systemmentioning

confidence: 99%

Role of telomere length in human carcinogenesis (Review)

et al. 2023

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Cancer is considered the most important clinical, social and economic issue regarding cause-specific disability-adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific DNA structures positioned at the end of chromosomes and consist of repetitive nucleotide sequences, which, together with shelterin proteins, facilitate the maintenance of chromosome stability, while protecting them from genomic erosion. Even though the connection between telomere status and carcinogenesis has been identified, the absence of a universal or even a cancer-specific trend renders consent even more complex. It is indicative that both short and long telomere lengths have been associated with a high risk of cancer incidence. When evaluating risk associations between cancer and telomere length, a disparity appears to emerge. Even though shorter telomeres have been adopted as a marker of poorer health status and an older biological age, longer telomeres due to increased cell growth potential are associated with the acquirement of cancer-initiating somatic mutations. Therefore, the present review aimed to comprehensively present the multifaceted pattern of telomere length and cancer incidence association.

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“…Another important environmental factor that can activate cellular senescence is air pollution. It is reported that some pollutants in Brazil, China, and South Africa may predispose cellular senescence by inducing telomere shortening or reducing catalase activity [260][261][262]. Furthermore, endothelial cells, skin keratinocytes, and mouse lung fibroblast can enter cellular senescence mode because of pollutants, fine dust, particulate matter 2.5, and polycyclic aromatic hydrocarbons via inducing senescence regulators, ROS, or the ATM serine/threonine kinase/H2A histone family member X pathway [263][264][265].…”

Section: Lifestyle Modificationsmentioning

confidence: 99%

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

et al. 2022

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Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role of MSCs in tissue homeostasis, aging-related diseases, and cellular therapy is clinically suggested. As aging is a universal problem that has large socioeconomic effects, an improved understanding of the concepts of aging can direct public policies that reduce its adverse impacts on the healthcare system and humanity. Several studies of aging have been carried out over several years to understand the phenomenon and different factors affecting human aging. A reduced ability of adult stem cell populations to reproduce and regenerate is one of the main contributors to the human aging process. In this context, MSCs senescence is a major challenge in front of cellular therapy advancement. Many factors, ranging from genetic and metabolic pathways to extrinsic factors through various cellular signaling pathways, are involved in regulating the mechanism of MSC senescence. To better understand and reverse cellular senescence, this review highlights the underlying mechanisms and signs of MSC cellular senescence, and discusses the strategies to combat aging and cellular senescence. Graphical Abstract

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Shortened telomere length in peripheral blood leukocytes of patients with lung cancer, chronic obstructive pulmonary disease in a high indoor air pollution region in China

Cited by 11 publications

References 40 publications

Causal relationship between atrial fibrillation and leukocyte telomere length: A two sample, bidirectional Mendelian randomization study

Causal relationship between atrial fibrillation and leukocyte telomere length: A two sample, bidirectional Mendelian randomization study

Role of telomere length in human carcinogenesis (Review)

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

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