Shot in the dark

Bhatti, M. Tariq; Gilbert, Aubrey L.; Watson, George; Waheed, Mark; Spencer, Doran

doi:10.1016/j.survophthal.2022.09.003

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Optic neuritis following vaccine administration has previously been reported for other anti-viral vaccines, including but not limited to measles/mumps/ rubella, influenza, rabies, tetanus/diphtheria/pertussis, hepatitis B and Herpes Zoster (Stübgen, 2013;Cheng and Margo, 2022a;Bhatti et al, 2023). There is no definitive causal relationship between vaccination and optic neuritis onset (Bhatti et al, 2023), although propositions of the etiopathogenesis include reaction to a vaccine component (e.g. protein or preparation adjuvant), molecular mimicry, production of proinflammatory cytokines, and/or activation of the innate and adaptive immune system (Bhatti et al, 2023).…”

Section: Discussionmentioning

confidence: 91%

“…There is no definitive causal relationship between vaccination and optic neuritis onset ( Bhatti et al., 2023 ), although propositions of the etiopathogenesis include reaction to a vaccine component (e.g. protein or preparation adjuvant), molecular mimicry, production of proinflammatory cytokines, and/or activation of the innate and adaptive immune system ( Bhatti et al., 2023 ). Nevertheless, reports of serious neurological sequelae following COVID-19 vaccination are still considered rare, especially in comparison with that caused by COVID-19 infection which has been found to be 617-fold higher in an analysis from the vaccine adverse event reporting system (VAERS) ( Frontera et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Optic neuritis was the most common complication following COVID-19 vaccination in this review. Optic neuritis following vaccine administration has previously been reported for other anti-viral vaccines, including but not limited to measles/mumps/ rubella, influenza, rabies, tetanus/diphtheria/pertussis, hepatitis B and Herpes Zoster (Stübgen, 2013;Cheng and Margo, 2022a;Bhatti et al, 2023). There is no definitive causal relationship between vaccination and optic neuritis onset (Bhatti et al, 2023), although propositions of the etiopathogenesis include reaction to a vaccine component (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Four cases were suspected of optic neuritis secondary to multiple sclerosis based on neuroimaging and CSF findings ( Matsuo et al., 2023 ; Shemer et al., 2023 ). IVMP was commenced for all 27 cases, with three cases further requiring PLEX ( Helmchen et al., 2022 ; Bhatti et al., 2023 ; Shemer et al., 2023 ). Improvement in visual function was noted for all except one case of unilateral NMO-associated optic neuritis where vision remained poor with optic atrophy observed following the second attack.…”

Section: Methods Of Literature Searchmentioning

confidence: 99%

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A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination

Shi,

Danesh-Meyer

2024

Front. Cell. Infect. Microbiol.

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BackgroundIt has become increasingly clear that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect most organs in the human body, including the neurologic and ophthalmic systems. Vaccination campaigns have been developed at rapid pace around the world to protect the population from the fast-mutating virus. This review seeks to summarise current knowledge of the neuro-ophthalmic manifestations of both COVID-19 infection and vaccination.Evidence acquisitionElectronic searches for published literature were conducted using EMBASE and MEDLINE on the 30th of July 2023. The search strategy comprised of controlled vocabulary and free-text synonyms for the following terms in various combinations: “coronavirus, COVID-19, SARS-CoV-2, 2019-nCoV, vaccination, vaccine, immunisation and neuro-ophthalmology”. No time range limits were set for the literature search. Published English abstracts for articles written in a different language were screened if available.ResultsA total of 54 case reports and case series were selected for use in the final report. 34 articles documenting neuro-ophthalmic manifestations following COVID-19 infection and 20 articles with neuro-ophthalmic complications following COVID-19 vaccination were included, comprising of 79 patients in total. The most commonly occurring condition was optic neuritis, with 25 cases following COVID-19 infection and 27 cases following vaccination against COVID-19.ConclusionsThe various COVID-19 vaccines that are currently available are part of the global effort to protect the most vulnerable of the human population. The incidence of neuro-ophthalmic consequences following infection with COVID-19 is hundred-folds higher and associated with more harrowing systemic effects than vaccination against the virus.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methods Of Literature Searchmentioning

confidence: 99%

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A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination

Shi,

Danesh-Meyer

2024

Front. Cell. Infect. Microbiol.

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“…The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) flow chart is shown in figure 1. There were 34 studies of ON following COVID-19 infection,12–45 and an equal number of publications reported patients with ON post-COVID-19 vaccination 46–78. There were 19 case series and the remaining 49 were case reports.…”

Section: Resultsmentioning

confidence: 99%

Systematic review exploring the clinical features of optic neuritis after SARS-CoV infection and vaccination

Georganta,

Chasapi,

Smith

et al. 2023

BMJ Open Ophth

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BackgroundThis study aims to characterise the symptoms and clinical features of optic neuritis (ON) following SARS-CoV-2 infection and vaccination.MethodA literature search was conducted in four databases (PubMed, Medline, Embase and Google Scholar) to identify relevant case reports and case series. The records were screened and articles adhering to the inclusion criteria were critically appraised.ResultsSixty-eight studies were found to be eligible for inclusion, including 34 reporting ON following SARS-CoV-2 infection and an equal number reporting cases postvaccination. In total 93 patients and 125 eyes were included. The infection cohort included 42 patients and 56 eyes, 51.2% were female and 33.3% experienced bilateral ON. The mean visual acuity was 1.64 log of minimum angle of resolution (LogMAR), while pain was present in 77.8%. Oligoclonal bands were present in 3 patients, myelin oligodendrocyte glycoprotein (MOG) antibodies in 18 patients and AQP-4 antibodies in 4 patients. The vaccination cohort included 51 patients and 69 eyes. 60.8% were female and 35.3% had a bilateral ON. The mean visual acuity was 0.93 LogMAR. Oligoclonal bands were present in 46.7%, MOG antibodies in nine patients and AQP-4 antibodies in three patients.ConclusionPatients with ON post-SARS-CoV infection were more likely to experience severe visual impairment than in cases following vaccination. Further research is required to outline the clinical features of ON after COVID-19 infection and vaccination, and establish causality.

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Tozinameran

2023

Reactions Weekly

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Shot in the dark

Cited by 4 publications

References 35 publications

A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination

A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination

Systematic review exploring the clinical features of optic neuritis after SARS-CoV infection and vaccination

Tozinameran

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