Should all nephrotics with thyroid dysfunction be treated with levothyroxine?

Kapoor, Kamal K.; Saha, Abhijeet

doi:10.1007/s00467-014-2926-0

Cited by 1 publication

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“…The urine protein level of patients in group B was higher than that in group A. APTT and Alb were lower than in group A, and the difference was statistically significant (P < 0.05), as showed in Table 1. euthyroid sick syndrome, which is widely believed to be an adaptive mechanism for energy conservation. 4 At present, there are few studies on the relationship between LT3S and platelet function in NS patients. The purpose of this study is to evaluate thyroid function, nutritional status, platelet activation function, and platelet aggregation function.…”

Section: General Informationmentioning

confidence: 99%

Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome

Guo

Chen

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE The objective of this study was to investigate the effects of low triiodothyronine syndrome (LT3S) on platelet function and clotting factors in patients with nephrotic syndrome(NS). METHODS Patients with primary nephrotic syndrome were divided into two groups, normal thyroid function (group A) and LT3S (group B), based on whether they had LT3S or not. Healthy subjects were selected as the control group (group C). Blood coagulation function was detected in each group. The platelet activation function (CD62P, CD63) was determined by flow cytometry. The platelet aggregation rate was detected by an optical method using adenosine diphosphate and arachidonic acid as inducers. RESULTS The proportion of primary nephrotic syndrome with LT3S was 23.2% (69/298). Compared with group C, group A had higher CD62P and PAgTADP, and group B had higher CD62P, CD63, PAgTAA, and PAgTADP; the difference was statistically significant (all P < 0.05). There was no significant difference in renal pathology between group A and group B (X2 = 4.957, P = 0.421). Compared with group A, the 24-hour urine protein, CD63, PAgTAA, and PAgTADP were higher in group B, and APTT and Alb were lower. The difference was statistically significant (P < 0.05). Logistic regression analysis showed that LT3S was associated with CD36 (OR: 3.516; 95% CI: 1.742~8.186; P = 0.004) and PAgTAA (OR: 0.442; 95% CI: 1.001~1.251; P = 0.037). CONCLUSION NS patients are prone to LT3S. Patients with LT3S may have abnormal platelet activation and increase of platelet aggregation.

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Section: General Informationmentioning

confidence: 99%