Should benzodiazepines be avoided?

Jørgensen, Mogens B.; Osler, Merete

doi:10.1111/acps.12943

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…In recent decades, the regulation of BZDs has become stringent, with withdrawal reactions upon discontinuation linked to patient tolerance. Concurrently, studies highlighting potential health risks associated with BZDs have emerged, revealing associations with increased mortality risks, traffic accidents, falls, hip fractures, cancer and cognitive decline 17 . Further research is warranted because of cognitive impairments attributed to BZDs and their potential long‐term impact on cognition and dementia.…”

Section: Discussionmentioning

confidence: 99%

Effective alleviation of depressive and anxious symptoms and sleep disorders in benzodiazepine‐dependent patients through repetitive transcranial magnetic stimulation

Chen,

Zhang

et al. 2024

Addiction Biology

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Benzodiazepine (BZD) dependence poses a significant challenge in mental health, prompting the exploration of treatments like repetitive transcranial magnetic stimulation (rTMS). This research aims to assess the impact of rTMS on alleviating symptoms of BZD dependence. A randomized control trial was employed to study 40 BZD‐dependent inpatients. Their symptoms were quantified using the Hamilton Anxiety Rating Scale (HAMA), Montgomery–Åsberg Depression Rating Scale (MADRS) and Pittsburgh Sleep Quality Index (PSQI). Participants were divided into a conventional treatment group (daily diazepam with gradual tapering) with supportive psychotherapy and another group receiving the same treatment supplemented with rTMS (five weekly sessions for 2 weeks). Significant improvements were observed in both groups over baseline in MADRS, HAMA and PSQI scores at the 2nd, 4th, 8th and 12th week assessments (p < 0.05). The group receiving rTMS in addition to conventional treatment exhibited superior improvements in all measures at the 8th and 12th weeks. The addition of rTMS to conventional treatment methods for BZD dependence significantly betters the recovery in terms of depression, anxiety and sleep quality, highlighting the role of rTMS as an effective adjunct therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Effective alleviation of depressive and anxious symptoms and sleep disorders in benzodiazepine‐dependent patients through repetitive transcranial magnetic stimulation

Chen,

Zhang

et al. 2024

Addiction Biology

View full text Add to dashboard Cite

show abstract

“…In anxious and/or minor depression BZD were a valid therapeutic option [65]. A commercial war was thus started: the dependence potential of BZD was dramatized, and their prescription was hindered in all possible ways, despite the clinical value of this class of medication [66,67]. Physicians thus learned that BZD were bad and could cause dependence, whereas AD were devoid of such effects.…”

Section: On Miseducationmentioning

confidence: 99%

Discontinuing Antidepressant Drugs: Lesson from a Failed Trial and Extensive Clinical Experience

Fava

Belaise

2018

Psychother Psychosom

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Levo-tetrahydropalmatine: A new potential medication for methamphetamine addiction and neurotoxicity

Liu

Zhao

et al. 2021

Experimental Neurology

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Should benzodiazepines be avoided?

Cited by 5 publications

References 9 publications

Effective alleviation of depressive and anxious symptoms and sleep disorders in benzodiazepine‐dependent patients through repetitive transcranial magnetic stimulation

Effective alleviation of depressive and anxious symptoms and sleep disorders in benzodiazepine‐dependent patients through repetitive transcranial magnetic stimulation

Discontinuing Antidepressant Drugs: Lesson from a Failed Trial and Extensive Clinical Experience

Levo-tetrahydropalmatine: A new potential medication for methamphetamine addiction and neurotoxicity

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