Should high-dose-rate brachytherapy boost be used in early nasopharyngeal carcinomas?

Guinot, José Luis; Moya, Andrea; Santos, Miguel; Peña, Marina; Quiles, B.; Sánchez-Relucio, J.C.; Rosa, Alonso La; Tortajada, M.I.; Arribas, L.

doi:10.1016/j.rpor.2020.04.001

Cited by 4 publications

(9 citation statements)

References 22 publications

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“…12 Guinot et al reported a local relapse rate (LRR) at 5 years of only 5% in T0-2 tumors by using ICBT boost. 13 Levendag et al showed that with ICBT in T1-2 N+ tumors the LRR was 0% with BT boost and 14% when no BT boost was used. 14 The BT boost was of little advantage in large recurrences where effective dose cannot be delivered effectively to the deeper tumor cells.…”

Section: Icbtmentioning

confidence: 99%

“…By using Rotterdam applicator radiation dose at 10 mm from the axis, results in doses of more than 200% to the surface, without any late complications. 24 PROCEDURE FOR ICBT 13 With the patient sitting comfortably in the chair, 10% Lidocaine solution was sprayed into the oral cavity and the oropharynx; along with 2% lignocaine jelly which was instilled in both the nostrils and the patient was asked to take deep breath through the nostril (this was done to anaesthetize and lubricate the nasopharynx and both nostrils) (Figure 1). 23 After 5 minutes, two 6Fr infant feeding tube were inserted through the nostrils (one in each nostril) and were taken out through mouth, with help of tongue depressor and surgical forceps (Figure 2).…”

Section: Icbt Techniques Availablementioning

confidence: 99%

“…23 After 5 minutes, two 6Fr infant feeding tube were inserted through the nostrils (one in each nostril) and were taken out through mouth, with help of tongue depressor and surgical forceps (Figure 2). 13 The two silicone tubes of the Rotterdam applicator were catheterized through the two ends of the feeding tubes, and with the help of middle and index fingers the applicator was guided into the oral cavity to the nasopharynx through the oropharynx, by pulling the two ends of the feeding tube from the nostril until the silicone tubes come out of the nostrils. After that the feeding tubes are completely pulled out and discarded.…”

Section: Icbt Techniques Availablementioning

confidence: 99%

“…The applicator is fixed into position (to prevent any dislodgement) by the help of stopper (Figure 3). 13 A suction catheter is used to suck out any oral secretion (to prevent aspiration).…”

Section: Icbt Techniques Availablementioning

confidence: 99%

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High dose rate brachytherapy in nasopharyngeal carcinoma: a neglected practice

Natasha,

Mahawar,

Devi

et al. 2024

Int J Res Med Sci

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Nasopharyngeal carcinomas (NPCs) are one of the most chemo- and radio- sensitive cancers of the head and neck region. It differs from other head and neck cancers in terms of signs and symptoms, treatment response and overall survival. Surgery is not the preferred treatment option, with chemoradiation being the treatment of choice, with an excellent local control rate, prognosis and overall survival. But the management of recurrent NPC is quite challenging and the treatment options available includes re-irradiation, chemotherapy, brachytherapy or surgery in rare cases. Re-irradiation in case of recurrent NPC is very difficult due to the already irradiated tissue in the radiation path, but re-irradiation with brachytherapy is an excellent treatment option for giving further doses of radiation to the nasopharynx in cases of recurrence or residual disease, by taking in consideration the already irradiated area and the radiation dose given before, and achieving a good local control rate and overall survival.

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Section: Icbtmentioning

confidence: 99%

Section: Icbt Techniques Availablementioning

confidence: 99%

Section: Icbt Techniques Availablementioning

confidence: 99%

Section: Icbt Techniques Availablementioning

confidence: 99%

See 2 more Smart Citations

High dose rate brachytherapy in nasopharyngeal carcinoma: a neglected practice

Natasha,

Mahawar,

Devi

et al. 2024

Int J Res Med Sci

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“…In 2020, approximately 133,000 people were diagnosed with NPC, and there were approximately 80,000 NPC-related deaths (a mortality rate of approximately 60%) (Sung et al, 2021). Due to the lack of effective early diagnostic indicators, most patients are diagnosed at an advanced stage and are prone to distant metastasis (Guinot et al, 2020;Brody-Camp et al, 2021). Therefore, early and accurate diagnosis is of great importance for the prevention and treatment of NPC.…”

Section: Introductionmentioning

confidence: 99%

Application of small extracellular vesicles in the diagnosis and prognosis of nasopharyngeal carcinoma

Zhang

Huang

Lan

et al. 2023

Front. Cell Dev. Biol.

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Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelium of the nasopharynx. The disease is insidious, and most patients are diagnosed at the advanced stage, resulting in poor prognosis. Early diagnosis is important to reduce NPC mortality. Small extracellular vesicles (sEVs) are rich in a variety of bioactive molecules, such as proteins, nucleic acids, and lipids, which can participate in the physiological and pathological regulation of the body by affecting the function of target cells. Numerous studies have shown that some RNAs and proteins in sEVs of tumor origin have a key role in the development of NPC and are potential candidates for malignancy detection. Studying the relationship between the cargoes of these sEVs and NPC may help in the diagnosis of the disease. Here in this review, we summarize the application of sEVs as biomarkers in the diagnosis of NPC and their role in NPC metastasis and prognosis. In addition, we discuss possible future applications and limitations of sEVs as biomarkers.

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