Should we customize PTV expansions for BMI? Daily cone beam computerized tomography to assess organ motion in postoperative endometrial and cervical cancer patients

Amini, Arya; DeWitt, Peter; Vinogradskiy, Yevgeniy; Rusthoven, Chad G.; Altunbas, Cem; Schefter, Tracey E.; Fisher, Christine M.

doi:10.1016/j.rpor.2016.02.003

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…“Short diameter 1”, as the most influencing factor of tumor regression, could be a potential factors affecting re-planning. As previously reported ( 24 , 25 ), the change of tumor volume affects the radioactive side effects to the bladder and rectum, which seems to indicate that the volume change of the bladder and rectum are negatively correlated with the change in tumor volume. This study found that the change in tumor size affected the patient’s original radiotherapy plan.…”

Section: Discussionsupporting

confidence: 80%

A model to guide the management and decision of re-planning during radiotherapy for cervical cancer

Zhang¹,

Li²,

Lin³

et al. 2021

Transl Cancer Res TCR

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Background: To establish a model to predict whether re-planning is needed in the process of cervical cancer radiotherapy. Methods: We collected the clinical indexes of 132 patients diagnosed with cervical cancer receiving concurrent chemotherapy and radiotherapy, including 33 factors about tumor markers [carcinoembryonic antigen (CEA), cancer antigen 125 (CA-125), squamous cell carcinoma antigen (SCC)], tumor volume, rectal volume, bladder volume, volumes receiving 30-50 Gy in organs-at-risk (OARs), and the maximum dose (Dmax) received by 1-2 cc in OARs. We established a multivariate model for re-planning evaluation via principal component analysis, and then verified the model based on the internal data. Results: We identified the dose index (P1), tumor size index (P2), and volumes receiving 30-50 Gy in OARs and the tumor (P3) as the three most weighted factors of the re-planning model. We set the cut-off for the re-planning modification requirement at 1. The model was consistent with R = 0.12P1 + 0.21P2 + 0.31P3, and it performed accurately that area under the test set characteristics curve (AUC) =0.826].Conclusions: Our proposed method can help to reduce image re-examination during treatment, decrease toxicities in OARs, shorten the radiotherapy course, lessen oncologists' efforts, and save medical resources.

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Section: Discussionsupporting

confidence: 80%

A model to guide the management and decision of re-planning during radiotherapy for cervical cancer

Zhang¹,

Li²,

Lin³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

show abstract

“…Amini et al demonstrated that a patient with BMI ≥30kg/m 2 had a 5-fold risk of having a translational shift ≥0.7 cm, showing the necessity of increasing the PTV for such patients beyond the 0.7 cm standard. 9 …”

Section: Discussionmentioning

confidence: 99%

“…Substantial evidence has shown that obesity represents a challenge in the RT of gynecologic cancers. 8 Obese patients and patients with a large hip circumference (HC) and umbilical anterior–posterior diameter had greater setup displacements, 9 , 10 , 11 , 12 , 13 because treatment requires daily imaging to ensure reproducibility of setup. Otherwise, expanding the target volumes may be necessary, especially where daily imaging is not practicable, which is the case in settings with reduced resources or high patient flow or particular circumstances, such as the coronavirus disease 2019 pandemic.…”

Section: Introductionmentioning

confidence: 99%