shRNA-interfering LSD1 inhibits proliferation and invasion of gastric cancer cells <i>via</i> VEGF-C/PI3K/AKT signaling pathway

Pan, Hongming; Lang, Weiya; Yao, Lijie; Wang, Yan; Xiao-ling, LI

doi:10.4251/wjgo.v11.i8.622

Cited by 19 publications

(14 citation statements)

References 37 publications

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“…DNA methylation and histone modification are both epigenetic modifications; that is, mammalian cells have unchanged DNA sequences and genetically altered gene expression. Both are mediated by the interaction between DNA methyltransferases (DNMTs) and histone deacetylases ( Pan et al, 2019 ). Under normal circumstances, DNA hypermethylation is mainly regulated by the DNMT family, including DNMT1, DNMT3A, and DNMT3B.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of different DNA methyltransferases in the pathogenesis of cancer

et al. 2022

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DNA methylation is one of the most essential epigenetic mechanisms to regulate gene expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the genome. In mammals, DNMTs act with some elements to regulate the dynamic DNA methylation patterns of embryonic and adult cells. Conversely, the aberrant function of DNMTs is frequently the hallmark in judging cancer, including total hypomethylation and partial hypermethylation of tumor suppressor genes (TSGs), which improve the malignancy of tumors, aggravate the ailment for patients, and significantly exacerbate the difficulty of cancer therapy. Since DNA methylation is reversible, currently, DNMTs are viewed as an important epigenetic target for drug development. However, the impression of DNMTs on cancers is still controversial, and therapeutic methods targeting DNMTs remain under exploration. This review mainly summarizes the relationship between the main DNMTs and cancers as well as regulatory mechanisms and clinical applications of DNMTs in cancer and highlights several forthcoming strategies for targeting DNMTs.

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Section: Introductionmentioning

confidence: 99%

Emerging role of different DNA methyltransferases in the pathogenesis of cancer

et al. 2022

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“…Meanwhile, KEGG terms such as transcriptional misregulation in cancer, Rap1 signaling pathway and PI3K-Akt signaling pathway were obtianed. PI3K-Akt signaling pathway had been reported to play an important role in the development of thyroid cancer [46,47], breast cancer [48], colorectal cancer [49], non-small cell lung cancer [50] and gastric cancer [51] etc.…”

Section: Discussionmentioning

confidence: 99%

Identification of hub genes in papillary thyroid carcinoma: robust rank aggregation and weighted gene co-expression network analysis

et al. 2020

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Background: Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic for PTC are incomplete. The purpose of this study is to identify potential biomarkers for diagnosis of PTC, and provide new insights into pathogenesis of PTC.Methods: Based on weighted gene co-expression network analysis, Robust Rank Aggregation, functional annotation, GSEA and DNA methylation, were employed for investigating potential biomarkers for diagnosis of PTC.Results: Black and turquoise modules were identified in the gene co-expression network constructed by 1807 DEGs that from 6 eligible gene expression profiles of Gene Expression Omnibus database based on Robust Rank Aggregation and weighted gene co-expression network analysis. Hub genes were significantly down-regulated and the expression levels of the hub genes were different in different stages in hub gene verification. ROC curves indicated all hub genes had good diagnostic value for PTC (except for ABCA6 AUC = 89.5%, the 15 genes with AUC > 90%). Methylation analysis showed that hub gene verification ABCA6, ACACB, RMDN1 and TFPI were identified as differentially methylated genes, and the decreased expression level of these genes may relate to abnormal DNA methylation. Moreover, the expression levels of 8 top hub genes were correlated with tumor purity and tumor-infiltrating immune cells. These findings, including functional annotations and GSEA provide new insights into pathogenesis of PTC. Conclusions:The hub genes and methylation of hub genes may as potential biomarkers provide new insights for diagnosis of PTC, and all these findings may be the direction to study the mechanisms underlying of PTC in the future.

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“…Although not extensively studied as histone methylases, KDMs are also associated with tumor progression and metastasis. For example, KDM1A (also known as LSD1)-mediated stabilization of SEPT6 can activate the TGF-β1/SMAD pathway and VEGF-C/PI3K/AKT signaling pathway, to stability promote the metastasis of GC, non-small cell lung cancer (NSCLC), and breast cancer ( 106 – 108 ). At the same time, KDM2A and KDM2B can downregulate the expression of programmed cell death 4 (PDCD4) and active the TGF-β1/SMAD and PI3K/AKT/mTOR pathways to stabilize and promote the metastasis of GC, lung cancer, pancreatic cancer, and ovarian cancer ( 109 – 111 ).…”

Section: Epigenetic In Tumor Progression and Metastasismentioning

confidence: 99%

Epigenetic modification regulates tumor progression and metastasis through EMT (Review)

et al. 2022

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Epigenetics is the study of heritable molecular determinants that are independent of phenotypic features. The epigenetic features include DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling. In multicellular organisms, the epigenetic state of a cell is critical in determining its differentiation status and its ability to perform its proper function. These processes are now well recognized as being a substantial factor in tumor progression and metastasis. The process through which epithelial cells acquire mesenchymal features is known as epithelial-mesenchymal transition (EMT). EMT is associated with tumorigenesis, invasion, metastasis, and resistance to therapy in cancer. In the present review, we examine the recent studies that demonstrate the biological role of epigenetics, in particular, DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling in tumor progression and metastasis by regulating EMT status, and we provide an overview of the current state of knowledge regarding the epigenetics involvement in tumor progression and metastasis. Because epigenetic changes can be reversed, learning more about their biological roles in EMT will not only help us better understand how cancer progresses and spreads, but it will also help us identify new ways to diagnose and treat human malignancy which is currently lacking in the clinical setting.

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shRNA-interfering LSD1 inhibits proliferation and invasion of gastric cancer cells via VEGF-C/PI3K/AKT signaling pathway

Cited by 19 publications

References 37 publications

Emerging role of different DNA methyltransferases in the pathogenesis of cancer

Emerging role of different DNA methyltransferases in the pathogenesis of cancer

Identification of hub genes in papillary thyroid carcinoma: robust rank aggregation and weighted gene co-expression network analysis

Epigenetic modification regulates tumor progression and metastasis through EMT (Review)

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