Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in <scp>d</scp>-galactose-induced aging mice

Zhou, Hong; Qu, Zhuo; Zhang, Jingze; Jiang, Bingjie; Liu, Changxiao; Gao, Wenyuan

doi:10.1039/c7ra13726e

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…Additionally, it was reported that the hippocampus is closely related to learning and memory activity (He et al., 2009). Overactivated astrocytes can intensify oxidative stress by reducing the number of neurons, inhibiting synaptic transmission, and releasing cytotoxic or neurotoxic substances, thus affecting the normal neuronal function and leading to cognitive impairment (Hou et al., 2019; Wang et al., 2014; Zhou et al., 2018). The expression of NeuN (Figure 8b) in the hippocampus was elevated after MAN administration, indicating that MAN can promote the regeneration of neurons in aging mice.…”

Section: Discussionmentioning

confidence: 99%

The protective effect and mechanism of mangiferin on D‐galactose‐induced oxidative stress and cognitive impairment in aging mice by an integrated network pharmacology and experimental validation strategy

Zhang,

Chen,

Wang

et al. 2023

Food Frontiers

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Mangiferin (MAN) was a natural bioactive xanthone with remarkable antioxidative, anti‐inflammatory, and antiapoptotic effects. The purpose of this study to determine the protective influence of MAN on D‐galactose (D‐gal)‐induced aging and cognitive impairment, together with its underlying molecular mechanism. The network pharmacology molecular docking analysis revealed that MAN has a potential binding with aging‐related oxidative stress and apoptosis proteins. In D‐gal‐induced aging mice, MAN could significantly reduce D‐gal‐induced histopathological changes of liver and brain tissues. Moreover, MAN administration obviously increased activities of antioxidant enzymes (SOD, T‐AOC, GSH‐Px, and CAT) and decreased levels of AChE and MDA in the serum, liver, or brain tissues. Additionally, MAN alleviated learning and memory disorders and improved the exploration ability. Western blotting and immunohistochemical analysis results revealed that MAN could regulate the expressions of PI3K/Akt/Nrf2 signaling pathway‐related proteins and apoptotic‐related proteins (Bax, Bcl‐2, and Caspase‐9) in the liver tissues. Therefore, these findings suggested that MAN can be used as a potent dietary supplement in functional foods for the protection against aging‐related impairments.

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Section: Discussionmentioning

confidence: 99%

The protective effect and mechanism of mangiferin on D‐galactose‐induced oxidative stress and cognitive impairment in aging mice by an integrated network pharmacology and experimental validation strategy

Zhang,

Chen,

Wang

et al. 2023

Food Frontiers

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“…SK-N-SH cells treated with H 2 O 2 for 24 h showed a dose-dependent cytotoxic effect, an increase in oxidative stress, activated caspase 3 activity, and acetylcholinesterase (AChE) inhibition activity (Sattayasai et al, 2013). In another study, the administration of 100 μm of H 2 O 2 to PC12 cells for 2 h suppressed the proliferation of cells and promoted shrinkage in the cell body, the release of LDH, increases in intra-cellular ROS, extra cellular NO, loss of MMP, which further induce apoptosis and damage dendritic networking, thereby inducing cell death (Xu et al, 2016;Zhou et al, 2018; Figure 4).…”

Section: Hydrogen Peroxidementioning

confidence: 99%

A systematic review for the development of Alzheimer’s disease in in vitro models: a focus on different inducing agents

Prajapat,

Kaur,

Choudhary

et al. 2023

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and is associated with dementia. Presently, various chemical and environmental agents are used to induce in-vitro models of Alzheimer disease to investigate the efficacy of different therapeutic drugs. We screened literature from databases such as PubMed, ScienceDirect, and Google scholar, emphasizing the diverse targeting mechanisms of neuro degeneration explored in in-vitro models. The results revealed studies in which different types of chemicals and environmental agents were used for in-vitro development of Alzheimer-targeting mechanisms of neurodegeneration. Studies using chemically induced in-vitro AD models included in this systematic review will contribute to a deeper understanding of AD. However, none of these models can reproduce all the characteristics of disease progression seen in the majority of Alzheimer’s disease subtypes. Additional modifications would be required to replicate the complex conditions of human AD in an exact manner. In-vitro models of Alzheimer’s disease developed using chemicals and environmental agents are instrumental in providing insights into the disease’s pathophysiology; therefore, chemical-induced in-vitro AD models will continue to play vital role in future AD research. This systematic screening revealed the pivotal role of chemical-induced in-vitro AD models in advancing our understanding of AD pathophysiology and is therefore important to understand the potential of these chemicals in AD pathogenesis.

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Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice

et al. 2019

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Despite tremendous advances in modern medicine, effective prevention or therapeutic strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) remain limited. Currently, accumulating evidence has demonstrated that microRNAs (miRNAs) are increasingly associated with age-related diseases and are emerging as promising therapeutic targets. Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, has been reported to have anti-oxidant, anti-inflammatory, and anti-apoptotic properties. The present study primarily focused on the ameliorative effect of urolithin A on aging mice and on the exploration of the potential mechanisms of such an ameliorative effect on cognitive impairment and brain aging. In this study, we first tested the neuroprotective effect of urolithin A using an in vitro H 2 O 2-induced PC12 cell oxidative damage model. The in vivo D-gal-induced brain aging model showed that urolithin A significantly suppressed the upregulation of miR-34a induced by D-gal. Moreover, target genes associated with miR-34a were also examined. Urolithin A supplementation ameliorated apoptosis induced by D-gal and rescued miR-34a overexpression-induced impaired autophagy in brain aging mice after a 2-month administration. Furthermore, urolithin A activated autophagy by upregulating the SIRT1 signaling pathway and downregulating the mTOR signaling pathway. In conclusion, urolithin A may exert neuroprotective effects and may aid in preventing D-gal-induced brain aging through activation of the miR-34a-mediated SIRT1/mTOR signaling pathway.

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Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in d-galactose-induced aging mice

Abstract: The Shunaoxin dropping pill (SNX) is derived from a traditional recipe.

Cited by 7 publications

References 22 publications

The protective effect and mechanism of mangiferin on D‐galactose‐induced oxidative stress and cognitive impairment in aging mice by an integrated network pharmacology and experimental validation strategy

The protective effect and mechanism of mangiferin on D‐galactose‐induced oxidative stress and cognitive impairment in aging mice by an integrated network pharmacology and experimental validation strategy

A systematic review for the development of Alzheimer’s disease in in vitro models: a focus on different inducing agents

Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice

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