Sialic acid: A novel marker of cardiovascular disease?

Gopaul, Karina; Crook, Martin

doi:10.1016/j.clinbiochem.2006.02.010

Cited by 110 publications

(95 citation statements)

References 137 publications

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“…Almost all sialic acid is bound to glycoproteins or glycolipids, and is released by acid treatment. Only 0.1% of total sialic acid is not bound [17]. Increased total sialic acid concentration in blood re ects an in ammatory phenotype [28].…”

Section: Discussionmentioning

confidence: 99%

“…Recently developed cytokine assays, based on ELISA or cytokine bead arrays, allow the measurement of multiple cytokines in small sample volumes, o ering the possibility of exploring new blood biomarkers in patients with CF. Furthermore, total sialic acid has been reported to be a robust in ammatory marker that tracks the acute phase response in several diseases [17]. Acute phase reactants and airway mucins are heavily sialated glycoproteins that increase in patients with CF.…”

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confidence: 99%

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Plasma biomarkers and cystic fibrosis lung disease

Cantin

Bilodeau²,

Larivée³

et al. 2012

CIM

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Plasma biomarkers and cystic brosis lung disease AbstractPurpose: e purpose of this study was to determine whether plasma biomarkers re ect changes in lung function and respiratory exacerbations associated with CF lung disease.Methods: Plasma human leukocyte elastase/alpha1 antitrypsin complex (pHLE complex) values were measured in 28 adult CF patients and 47 healthy volunteers and correlated with forced expiratory volume (FEV1) and forced vital capacity (FVC). pHLE complexes were studied during respiratory exacerbations and a er antibiotic therapy. Plasma cytokines and sialic acid were also measured.Results: pHLE complexes were increased in CF patients (p < 0.01), were inversely correlated with FEV1 (r = 0.71) and FVC (r = 0.67) and returned to normal levels a er intravenous antibiotics (p < 0.001). Plasma cytokines did not correlate with lung function. Total sialic acid increased during CF respiratory exacerbations and decreased a er antibiotic therapy.Conclusion: Plasma sialic acid and pHLE complexes re ect clinically meaningful changes in CF lung disease. In contrast, plasma cytokine levels did not correlate with lung function.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Plasma biomarkers and cystic fibrosis lung disease

Cantin

Bilodeau²,

Larivée³

et al. 2012

CIM

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“…Furthermore, N ‐acetylneuraminic acid has been indicated to be the predominant form of sialic acid. Because sialic acids are so widespread on cell surfaces or as circulatory molecules, their alterations may have diverse effects on the pathogenesis of CVD 5, 6. Oxidative stress is involved in the pathogenesis and progression of CVD 7.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and cardiovascular protective effects of quercetin 7‐O‐sialic acid

Tian

Liu

Qin

et al. 2016

J Cellular Molecular Medi

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Oxidative stress and inflammation play important roles in the pathogenesis of cardiovascular disease (CVD). Oxidative stress‐induced desialylation is considered to be a primary step in atherogenic modification, and therefore, the attenuation of oxidative stress and/or inflammatory reactions may ameliorate CVD. In this study, quercetin 7‐O‐sialic acid (QA) was synthesized aiming to put together the cardiovascular protective effect of quercetin and the recently reported anti‐oxidant and anti‐atherosclerosis functions of N‐acetylneuraminic acid. The biological efficacy of QA was evaluated in vitro in various cellular models. The results demonstrated that 50 μM QA could effectively protect human umbilical vein endothelial cells (HUVEC, EA.hy926) against hydrogen peroxide‐ or oxidized low‐density lipoprotein‐induced oxidative damage by reducing the production of reactive oxygen species. QA attenuated hydrogen peroxide‐induced desialylation of HUVEC and lipoproteins. QA decreased lipopolysaccharide‐induced secretion of tumour necrosis factor‐α (TNF‐α) and monocyte chemoattractant protein‐1 (MCP‐1), and it significantly reduced the expression of intercellular adhesion molecule‐1, vascular cell adhesion molecule‐1, TNF‐α and MCP‐1. Furthermore, QA effectively promoted cholesterol efflux from Raw 264.7 macrophages to apolipoprotein A‐1 and high‐density lipoprotein by up‐regulating ATP‐binding cassette transporter A1 and G1, respectively. Results indicated that the novel compound QA exhibited a better capacity than quercetin for anti‐oxidation, anti‐inflammation, cholesterol efflux promotion and biomolecule protection against desialylation and therefore could be a candidate compound for the prevention or treatment of CVD.

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“…The level of different types of serum glycoproteins are maintained within a narrow range in health [10], but is elevated in many pathological conditions viz. tuberculosis [11], autoimmune disease [12], cardiovascular disease [13,14], diabetes mellitus [15], cancer of cervix [16], uterus [17] and breasts [18], and arthritis [19]. Thus, it is of great interest to identify and validate serum glycoproteins whose change in levels may provide new insight into cancer progression and may have utility as potential markers for cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer

et al. 2013

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Identification of reliable biomarkers for detection and staging of cancer and monitoring the outcome of anticancer therapy has been considered to be of high importance. We aimed to estimate the levels of serum glycoproteins, protein bound-hexose, protein bound hexosamine, protein bound fucose, protein bound sialic acid and protein bound carbohydrate in 32 ovarian cancer patients and compared them with the levels that found in 25 normal subjects. As compared to the normal subjects, all the four fractions of glycoproteins level were significantly elevated in ovarian cancer patients (p \ 0.05). Chemotherapy in these patients significantly decreased the levels of serum glycoproteins (p \ 0.05). Thus, high levels of serum glycoproteins in ovarian cancer patients could be due to abnormal protein glycosylation indicating malignant transformation of the cells.

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Sialic acid: A novel marker of cardiovascular disease?

Cited by 110 publications

References 137 publications

Plasma biomarkers and cystic fibrosis lung disease

Plasma biomarkers and cystic fibrosis lung disease

Synthesis and cardiovascular protective effects of quercetin 7‐O‐sialic acid

Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer

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