Sibling cord blood donor program for hematopoietic cell transplantation: the 20-year experience in the Rome Cord Blood Bank

Screnci, Maria; Murgi, Emilia; Valle, Veronica; Tamburini, Anna; Pellegrini, Maria Grazia; Strano, Sabrina; Corona, Francesca; Ambrogi, Eleonora Barbacci; Girelli, Gabriella

doi:10.1016/j.bcmd.2015.12.010

Cited by 7 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 3.5% bacterial contamination rate observed in our cohort was comparable to those reported in other studies; 33,34 bacterial contaminations could be addressed at the time of transplantation with prophylactic antibiotics if necessary.…”

Section: Discussionsupporting

confidence: 89%

“…The cellular and biological characteristics of our banked units were comparable to those reported by other directed CBB programs 13,26,33 with a utilization rate reaching 8% of the 338 CBUs collected over 20 years, and 19% of the typed units. Similar low utilization rates of banked sibling CBUs for hematologic disorders have been reported by many authors.…”

Section: Discussionsupporting

confidence: 79%

“…While 65% of our CBUs had cellular characteristics (minimal collected TNC count of 5×10 8 ) adequate to support allogeneic CBT in the pediatric setting, 26,34 only 13% (n=45) of our collections provided the TNC dose and volume recommended for unrelated CBU banking (initial volume >80 mL and TNC >18×10 8 ). However, the low cellular content should not be a limitation for the use of these CBU, 31,33 particularly when there is an opportunity to increase the cell dose by combining CB with BM collected from the same sibling donor, an approach that proved to be effective with excellent overall survival and low incidence of GvHD, as noted by many authors. 13,30,31,35 …”

Section: Discussionmentioning

confidence: 97%

“…Similar low utilization rates of banked sibling CBUs for hematologic disorders have been reported by many authors. 30–33 …”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks

Rafii

Bernaudin

Rouard³

et al. 2017

Haematologica

View full text Add to dashboard Cite

Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units to be stored, discarded, or used for other endeavors. We report here 20 years of experience in family cord blood banking for sickle cell disease in two dedicated public banks. Participants were pregnant women who had a previous child diagnosed with homozygous sickle cell disease. Participation was voluntary and free of charge. All mothers underwent mandatory serological screening. Cord blood units were collected in different hospitals, but processed and stored in two public banks. A total of 338 units were stored for 302 families. Median recipient age was six years (11 months-15 years). Median collected volume and total nucleated cell count were 91 mL (range 23–230) and 8.6×108 (range 0.7–75×108), respectively. Microbial contamination was observed in 3.5% (n=12), positive hepatitis B serology in 25% (n=84), and homozygous sickle cell disease in 11% (n=37) of the collections. Forty-four units were HLA-identical to the intended recipient, and 28 units were released for transplantation either alone (n=23) or in combination with the bone marrow from the same donor (n=5), reflecting a utilization rate of 8%. Engraftment rate was 96% with 100% survival. Family cord blood banking yields good quality units for sibling transplantation. More comprehensive banking based on close collaboration among banks, clinical and transplant teams is recommended to optimize the use of these units.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 97%

“…Similar low utilization rates of banked sibling CBUs for hematologic disorders have been reported by many authors. 30–33 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks

Rafii

Bernaudin

Rouard³

et al. 2017

Haematologica

View full text Add to dashboard Cite

show abstract

“…Both of the abovementioned stem cells derived from umbilical cord blood could be used to repair and restore damaged tissues and treat diseases such as cancer, blood and neurological disorders, and immune deficiencies because of their tremendous proliferation and differentiation potential and great regenerative capacity. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] In addition, these candidate cells have a great paracrine mechanism on other cells. 27 This biological mechanism could increase stem cells' regenerative capacity.…”

Section: Umbilical Cord Blood-stem Cells Benefits and Featuresmentioning

confidence: 99%

Umbilical Cord Blood Stem Cells as a Beneficial Option in Cell-Based Therapy and Regenerative Medicine

Kowsari

Jafarian

Qomi

et al. 2017

JSRT

View full text Add to dashboard Cite

Stem cells are unique cells obtained from a broad range of tissues with different features related to proliferation capability and differentiation capacity. As one of the most important stem cell types in medicine today, umbilical cord blood-derived stem cells (UCB-SCs) are a more practical choice than embryonic stem cells because their use does not involve ethical issues. For example, these cells are a powerful tool used in cell-based therapy and regenerative medicine to treat cancer and neurological, autoimmune, cardiovascular, and blood diseases. In this article, we perform a mini review of umbilical cord blood-derived stem cells as an effector option in cell-based therapy and regenerative medicine.

show abstract

Current Cord Blood Banking Concepts and Practices

Page

Kurtzberg

2017

Cord Blood Transplantations

View full text Add to dashboard Cite

Sibling cord blood donor program for hematopoietic cell transplantation: the 20-year experience in the Rome Cord Blood Bank

Cited by 7 publications

References 9 publications

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks

Umbilical Cord Blood Stem Cells as a Beneficial Option in Cell-Based Therapy and Regenerative Medicine

Current Cord Blood Banking Concepts and Practices

Contact Info

Product

Resources

About