Sick leave and disability pension in Hodgkin lymphoma survivors by stage, treatment, and follow-up time—a population-based comparative study

Glimelius, Ingrid; Ekberg, Sara; Linderoth, Johan; Jerkeman, Mats; Chang, Ellen T.; Neovius, Martin; Smedby, Karin E.

doi:10.1007/s11764-015-0436-0

Cited by 41 publications

(42 citation statements)

References 38 publications

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“…Since OS did not differ between the groups with the available follow-up time, this study calls for the need of investigating the occurrence of late effects, such as hospitalization [21], secondary AML [22], breast cancer and other secondary malignancies [23,24] heart and lung diseases [25], future fertility [26] and the risk of sick leave and disability pension [27] between children and adults receiving different treatment concepts.…”

Section: Discussionmentioning

confidence: 99%

Hodgkin lymphoma in children, adolescents and young adults – a comparative study of clinical presentation and treatment outcome

et al. 2017

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Background: Hodgkin lymphoma (HL) treatment protocols for children, adolescents and young adults traditionally differ, but the biological and clinical justification for this remains uncertain. Material and methods: We compared age-dependent clinical presentation and treatment and outcome for 1072 classical HL patients 0-24 years diagnosed in Denmark (1990Denmark ( -2010 and Sweden (1992Sweden ( -2009 in pediatric (n ¼ 315, Denmark <15 years, Sweden <18 years) or adult departments (n ¼ 757). Distribution of clinical characteristics was assessed with Pearson's chi 2 -test and Mantel-Haenszel trend test. The Kaplan-Meier method was used for survival analyses. Hazard ratios (HR) were used to compare the different treatment groups and calculated using Cox regression. Results: Children (0-9 years) less often presented with advanced disease than adolescents (10-17 years) and young adults (18-24 years) (stage IIB-IV: children 32% vs. adolescents 50%, and adults 55%; p < .005). No variation in overall survival (OS) was seen between pediatric and adult departments or by country. Danish pediatric patients received radiotherapy (36%) less frequently than Swedish pediatric patients (71%) (p < .0001). Ten-year event-free survival (EFS) was lower among Danish pediatric patients (0-14 years) (0.79; 95% confidence interval (CI) 0.70-0.86) than among Swedish pediatric patients (0-17 years) (0.88; 95% CI 0.83-0.92), HR (1.93; 95% CI 1.08-3.46). A similar pattern was seen between adult patients in the two countries: Denmark 10-year EFS 0.85 (95% CI 0.81-0.88), Sweden 0.88 (95% CI 0.84-0.91), adjusted HR 1.51 (95% CI 1.03-2.22). Conclusion: Adolescents and young adults shared similar clinical presentation suggesting a rationale of harmonized treatment for these groups. Both adult and pediatric protocols provided high OS with no significant difference between the departments. The less frequent use of radiotherapy in Danish pediatric patients corresponded to a lower EFS, but comparable OS in all groups confirmed effective rescue strategies for the relapsing patients.

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Section: Discussionmentioning

confidence: 99%

Hodgkin lymphoma in children, adolescents and young adults – a comparative study of clinical presentation and treatment outcome

et al. 2017

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“…Sick‐leave episodes longer than 14 days in the year starting 2 years before the diagnosis of rectal cancers (or match date for the comparators) were registered from the first day, using data from the MiDAS database kept by the Swedish Social Insurance Agency. Unemployment status in the year before diagnosis (or match date for the comparators) was available from the Longitudinal Integrated Database for Health Insurance and Labour Market Studies (LISA) held at Statistics Sweden.…”

Section: Methodsmentioning

confidence: 99%

Risk of disability pension in patients following rectal cancer treatment and surgery

Chen

Glimelius

Neovius

et al. 2015

British Journal of Surgery

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“…Net days were calculated by multiplying the degree of compensation with the number of compensated days. Dates and extent of SL and DP are recorded in the Micro Data for Analysis of the Social Insurance database (MiDAS) maintained by the Swedish Social Insurance Agency since 1994 (24). Individuals who are registered as unemployed are also entitled to sickness absence compensations.…”

Section: Work Lossmentioning

confidence: 99%

Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss

Chen

Glimelius

Neovius

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The number of working-age rectal cancer survivors is increasing due to early detection and improved treatment. However, work loss duration and predictors among them have not been studied thoroughly.Methods: We identified 3,438 patients with stage I-III rectal cancer, 18 to 61 years of age in the Swedish Colorectal Cancer Register 1996-2009. Information on work loss due to sick leave or disability pension was collected from 2 years before diagnosis to 5 years after (until December 31st, 2013). Incidence rate ratios (IRR) of work loss were estimated in a negative binominal model by clinical characteristics for the 1st and 2nd-5th years after diagnosis. Patients were stratified by prediagnostic work loss.Results: Patients without prediagnostic work loss (74%) experienced median 147 days (25th and 75th percentile: 55 and 281) of work loss during the 1st year after diagnosis. Work loss rates

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Sick leave and disability pension in Hodgkin lymphoma survivors by stage, treatment, and follow-up time—a population-based comparative study

Abstract: The results call for increased awareness and evaluation of reasons for long-term work disability following intensive chemotherapy among young HL survivors.

Cited by 41 publications

References 38 publications

Hodgkin lymphoma in children, adolescents and young adults – a comparative study of clinical presentation and treatment outcome

Hodgkin lymphoma in children, adolescents and young adults – a comparative study of clinical presentation and treatment outcome

Risk of disability pension in patients following rectal cancer treatment and surgery

Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss

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