Sick leave due to back pain, common mental disorders and disability pension: Common genetic liability

Abstract

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Psychosocial Working Conditions and Subsequent Sickness Absence—Effects of Pain and Common Mental Disorders in a Population-Based Swedish Twin Sample

“…Genetic effects are known to underlie pain, 19 CMDs, 20 – 22 and their mutual associations 19 , 23 – 25 as well as to SA 26 , 27 highlighting the need to control for familial confounding, that is, genetics and shared, mainly childhood, environmental factors in such studies. Earlier research also indicate that genetics may play a role in psychosocial working conditions 28 , 29 hence it would be important to investigate the associations between psychosocial working conditions and SA controlling for familial factors, which are available in a twin sample.…”

Role of social benefits for future long-term sickness absence, disability pension and unemployment among individuals on sickness absence due to mental diagnoses: a competing risk approach

“…Furthermore, we had a large working age population-based sample which enabled us to identify almost 4000 first incident SA spells due to mental diagnoses to be followed for labor market outcomes. A limitation of this study is that we had only register data and therefore lacked access to many social, health related or lifestyle factors affecting employment o sustainable working life (Dorner et al 2015;Mather et al 2020;Mather et al 2019a;Mather et al 2019b). The utilization of register data, although from multiple sources, do not completely rule out common method bias (Podsakoff et al 2012) which may have inflated our results, but one can assume that the direction of associations would be retained.…”

The role of sickness absence diagnosis for the risk of future inpatient- or specialized outpatient care in a Swedish population-based twin sample

“…Our results based on the comparison of the whole cohort to discordant twin pairs showed the point estimates to retain the magnitude and direction, suggesting there is weak or no effect of familial confounding in the associations between SA due to various diagnosis groups and patient care. Hence this independency from familial confounding suggest direct link between SA and patient care although we expected to see familial confounding based on the genetic influence on many chronic diseases that leads to SA [25][26][27][28], but also on SA itself [9,22]. For (occupational) health care including any preventive actions for SA and/or hospitalizations in terms of inpatient-or specialized outpatient care means both tailored interventions specified by the underlying condition or diagnosis as well as monitoring SA.…”

“…SA is commonly prescribed in healthcare [8]. A lot of research have indicated that SA plays a role for many consequences, not only for disability pension (DP) [9,10], but also for mortality or even suicide [11][12][13]. However, even theoretically the effects of SA for an individual are complex and varying based on the life situation [14,15], whereas SA is also known to increase the risk of reoccurring SA, DP and unemployment [16][17][18][19].…”

“…blood pressure [28]. Since genetics is also known to affect SA [9,22], there is a need for studies accounting for familial factors (genetics and mainly childhood environment) in associations of SA and potential consequences. A twin study with a co-twin control design utilizing twin pairs discordant for a factor of interest provides possibility to define if an association between SA and inpatient care is influenced by familial factors [29,30].…”