Sickle cell disease: from molecular aspects to clinical practice. A case report and a literature analysis

Moynot, Jean-Clair; Commandeur, Diane; Déserts, Marc Danguy des; Montelescaut, Etienne; Kenane, N.; Drouillard, I.

doi:10.1684/abc.2011.0633

Cited by 6 publications

(13 citation statements)

References 6 publications

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“…The role for antibioprophylaxis is discussed by many, and two strategies seem to co‐exist in the literature. There are authors recommending prophylaxis according to type of surgery, and others adapting it to the individual patients' medical histories . As a standout, splenectomy needs specific considerations, including preoperative immunizations against encapsulated bacteria, as in the context of asplenia .…”

Section: Resultsmentioning

confidence: 99%

“…Thrombophilia evaluation is suggested, in some reviews . Preoperative preparation occasionally includes chest physiotherapy and intra‐venous hydration during the fasting period . Bicarbonate treatment, as a prevention to acidosis, has been reported as a standard treatment in older manuscripts .…”

Section: Resultsmentioning

confidence: 99%

“…Regarding thresholds, earlier recommendations advocate “no transfusion” prior to surgery or minor risk surgeries, as long as the hemoglobin level was >4 to 5 g/dL . This limit had the tendency to move upwards with time, many authors currently recommending a hemoglobin level ≥9‐10 g/dL, before minor to intermediate risk surgery, whilst some groups still advocate 7 g/dL .…”

Section: Resultsmentioning

confidence: 99%

“…To avoid a prolonged fasting period, and reduce anxiety, groups have suggested to start the daily elective procedure program with SCD patients and to schedule the operation early in the morning . All anesthesia techniques and standard drugs are deemed appropriate and safe for the use in SCD patients according to many . Some recommend general anesthesia as a preferred strategy whereas others suggest locoregional anesthesia with proper sedation when possible .…”

Section: Resultsmentioning

confidence: 99%

“…Premedication with anxiolytics is controversial, with one review advocating against it, if at all possible . Others suggest a careful selection of drugs to achieve anxiolysis and avoid any secondary respiratory depression . Regarding mechanical ventilation, tracheal intubation is deemed superior to mask ventilation according to one case report .…”

Section: Resultsmentioning

confidence: 99%

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Perioperative care of children with sickle cell disease: A systematic review and clinical recommendations

et al. 2019

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Children with sickle cell disease (SCD) require specific perioperative care, and clinical practice in this area remains poorly defined. We aimed to conduct a systematic, PRISMA-based review of the literature, available clinical guidelines and practice recommendations. We also aimed to extract any valuable information for the "best of available-evidence"-based prevention of perioperative adverse events in children with SCD, and highlight the most urgent priorities in clinical research. As data sources, USWe also included institutional, consortia and expert group guidelines. Included were reports/guidelines in English, French, German, and Italian. Excluded were reports on obstetrical and fetal management. We identified 202 reports/guidelines fulfilling the criteria outlined above. A majority focused on visceral, cardiovascular and orthopedic surgery procedures, and only five were multicenter randomized controlled trials and two prospective randomized studies. After grading of the quality of the evidence, the extracted data was summarized into clinical recommendations for daily practice. Additionally, we designed a risk-grading algorithm to identify contexts likely to be associated with adverse outcomes. In conclusion, we provide a systematic PRISMA-based review of the existing literature and ancillary practice and delineate a set of clinical recommendations and priorities for research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Perioperative care of children with sickle cell disease: A systematic review and clinical recommendations

et al. 2019

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État de sensibilisation allergénique au café et au thé chez le drépanocytaire atopique

Adou

Siransy

Yeboah

et al. 2017

Revue Française d'Allergologie

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Antisickling and Antihemolytic Mechanism of Spirulina platensis (Oscillatoriaceae): A Nutraceutical Commonly Used in Cameroon

Teguem Tchoulegheu,

Nya Nkwikeu,

Lena Yembeau

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Sickle cell anaemia (SCA) is a widespread genetic disease in Africa, associated with chronic hemolytic anaemia and vaso-occlusive and infectious complications. The most commonly used means of management and treatment such as blood transfusions and allografting are expensive and predispose patients to the risk of infections. This research study aimed at evaluating the antisickling and antihemolytic activities of aqueous extracts of Spirulina platensis from Cameroon for optimising the management of this disease using natural substances. The Spirulina platensis harvested in Nomayos-Yaounde was dried, crushed, and macerated for 24 h in distilled water and the filtrate was freeze dried. The determination of the inhibition rates of falciformation induced by 2% sodium metabisulfite (MBS) and the sickling reversibility rate was carried out at different concentrations (100, 200, 400, 800, and 1600 μg·mL−1) of the spirulina extract at different time intervals (2 h, 4 h, and 24 h). Aspirin, hypotonic solution, Triton X-100, and hydrogen peroxide were used as hemolytic inducers and the antihemolytic activity of the extract was studied at 800 μg·mL−1 and 1600 μg·mL−1 using the colorimetric method. The extraction yield was 14.015%. The maximum duration of induced falciformation was 2 h 30 min and the percentage of falciformation increased from 27.99 ± 3.15% (at the initial time) to 91.44 ± 3.70%, giving a falciformation induction rate of 69.3%. The falciformation inhibition rate after 2 h 30 min ranges from 15.10 ± 0.60% to 66.09 ± 4.69% for the concentration of 100 μg·mL−1 to 1600 μg·mL−1 of the spirulina extract. This rate of inhibition of falciformation was found to be dose-dependent. The best concentration of the extract was 1600 μg·mL−1. The reversibility rate of falciformation at 800 μg·mL−1 and 1600 μg·mL−1 varied from 37.54 ± 6.35% to 82.34 ± 5.63% as a function of time. 1600 μg·mL−1 was the most active concentration after 24 h. In addition, the extract improved the Fe2+/Fe3+ ratio with an increase in the rates of 69.78 ± 8.81 and 69.78 ± 13.82 at 800 μg·mL−1 and 1600 μg·mL−1, respectively. According to each inducer at 800 μg·mL−1 and 1600 μg·mL−1, respectively, of the spirulina extract, the following rates of inhibition of hemolysis were found: 53.03 ± 9.46% and 96.67 ± 5.77% (aspirin); 80 ± 8.66% and 71.25% (hypotonic solution); 36.56 ± 9.53% and 45.67 ± 22.55% (Triton X-100); 24.26 ± 9.55% and 36.76 ± 1.27% (hydrogen peroxide). At the end of this study, the best antickling activities were obtained at the concentrations 800 μg·mL−1 and 1600 μg·mL−1. It also has antihemolytic properties on various hemolysis inducers at concentrations 800 μg·mL−1 and 1600 μg·mL−1 with inhibition rates varying from 36% to 96%.

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Sickle cell disease: from molecular aspects to clinical practice. A case report and a literature analysis

Cited by 6 publications

References 6 publications

Perioperative care of children with sickle cell disease: A systematic review and clinical recommendations

Perioperative care of children with sickle cell disease: A systematic review and clinical recommendations

État de sensibilisation allergénique au café et au thé chez le drépanocytaire atopique

Antisickling and Antihemolytic Mechanism of Spirulina platensis (Oscillatoriaceae): A Nutraceutical Commonly Used in Cameroon

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