Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children

Ntoumi, Francine; Ekala, Marie-Thérèse; Makuwa, Maria; Lékoulou, Faustin; Mercereau‐Puijalon, Odile; Deloron, Philippe

doi:10.1016/s0165-2478(02)00131-1

Cited by 32 publications

(31 citation statements)

References 33 publications

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“…To date, a single study compared antibodies to MSP2 according to the haemoglobin type in Gabon. Similar prevalence rates of IgG and IgG subclasses of MSP2 family-specific antibodies were observed in AA and AS haemoglobin groups, except for IgG2 being more prevalent in AS children [40]. It was proposed that IgG2 in AS plasmas led to a lower efficiency of the cytophilic IgG3 to reduce the parasite burden, explaining the higher complexity of P. falciparum infections in AS isolates [41].…”

Section: Discussionmentioning

confidence: 73%

Impact of red blood cell polymorphisms on the antibody response to Plasmodium falciparum in Senegal

Sarr

Pelleau

Toly

et al. 2006

Microbes and Infection

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Section: Discussionmentioning

confidence: 73%

Impact of red blood cell polymorphisms on the antibody response to Plasmodium falciparum in Senegal

Sarr

Pelleau

Toly

et al. 2006

Microbes and Infection

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“…A cross-sectional survey was conducted in May to June 2000 in a cohort of 641 asymptomatic children between the ages of 1 and 12 y. Further details on the study population and data collection procedures have been published elsewhere (57). After obtaining informed consent from all parents, venous blood samples were collected for parasitological assessment for Plasmodium spp.…”

Section: Methodsmentioning

confidence: 99%

Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa

Day

Artzy‐Randrup

Tiedje

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Existing theory on competition for hosts between pathogen strains has proposed that immune selection can lead to the maintenance of strain structure consisting of discrete, weakly overlapping antigenic repertoires. This prediction of strain theory has conceptual overlap with fundamental ideas in ecology on niche partitioning and limiting similarity between coexisting species in an ecosystem, which oppose the hypothesis of neutral coexistence. For Plasmodium falciparum, strain theory has been specifically proposed in relation to the major surface antigen of the blood stage, known as PfEMP1 and encoded by the multicopy multigene family known as the var genes. Deep sampling of the DBLα domain of var genes in the local population of Bakoumba, West Africa, was completed to define whether patterns of repertoire overlap support a role of immune selection under the opposing force of high outcrossing, a characteristic of areas of intense malaria transmission. Using a 454 high-throughput sequencing protocol, we report extremely high diversity of the DBLα domain and a large parasite population with DBLα repertoires structured into nonrandom patterns of overlap. Such population structure, significant for the high diversity of var genes that compose it at a local level, supports the existence of "strains" characterized by distinct var gene repertoires. Nonneutral, frequency-dependent competition would be at play and could underlie these patterns. With a computational experiment that simulates an intervention similar to mass drug administration, we argue that the observed repertoire structure matters for the antigenic var diversity of the parasite population remaining after intervention.Plasmodium falciparum | var genes | parasite diversity | strain structure | Gabon

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“…Details on the study population and data collection procedures have been published elsewhere. 16 Briefly, after obtaining informed consent from all individuals and/or their parents, venous blood was collected in tubes containing EDTA for parasitologic assessment, genotyping of the sickle cell trait, and determination of ABO blood group. Unsuccessful Hb phenotyping was due to an insufficient volume of sample rather than technical problems.…”

Section: Methodsmentioning

confidence: 99%

Association of Haptoglobin Levels With Age, Parasite Density, and Haptoglobin Genotype in a Malaria-Endemic Area of Gabon

Fowkes

Imrie

Migot-Nabias

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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Abstract. Haptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1-12-year-old children was conducted in the rainy season, a period of high malaria transmission, to examine this relationship. Variables that influenced Hp levels were Hp genotype, location, and age interacting with parasite density. At low parasite densities, there was a negative correlation between Hp levels and age. At higher densities, there was a positive correlation with age. This suggests that in the presence of greater parasiteinduced hemolysis, older children are capable of increased production of Hp. Sickle cell trait and ABO blood group was not associated with Hp levels in this population.

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Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children

Cited by 32 publications

References 33 publications

Impact of red blood cell polymorphisms on the antibody response to Plasmodium falciparum in Senegal

Impact of red blood cell polymorphisms on the antibody response to Plasmodium falciparum in Senegal

Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa

Association of Haptoglobin Levels With Age, Parasite Density, and Haptoglobin Genotype in a Malaria-Endemic Area of Gabon

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