2003
DOI: 10.1002/jtra.10022
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Side effects of lithium on rat cranial arachnoid and dura mater collagen: A quantitative ultrastructural study

Abstract: Lithium is widely used in medicine as an antidepressive drug. Despite abundant literature on the subject, questions on the effects of lithium on collagen, which is one of the major components of tissues and organs, are far from being answered. We have examined the effects of lithium chloride (1.5 meq/kg of body weight) on rat cranial arachnoid and dura mater collagen fibrils by electron microscopy and image analysis. Animals were sacrificed 1 day, 2, 6, and 12 months after the end of a 30-consecutive days expe… Show more

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Cited by 3 publications
(3 citation statements)
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“…This was also observed in mouse, rat, and rabbit skin [16À19]; rat and rabbit liver [19]; mouse bone [14]; as well as in rat arachnoid and dura mater collagen [22]. Rupture of the aorta is influenced by lithium.…”
Section: Resultsmentioning
confidence: 57%
“…This was also observed in mouse, rat, and rabbit skin [16À19]; rat and rabbit liver [19]; mouse bone [14]; as well as in rat arachnoid and dura mater collagen [22]. Rupture of the aorta is influenced by lithium.…”
Section: Resultsmentioning
confidence: 57%
“…Animals were injected (intraperitonealy) once a day for 30 consecutive days and were kept in groups of four; they were sacrificed 1 day, 1, 2, and 6 months after the last injection. The reasons for choosing these parameters for lithium administration are given elsewhere [26]. This was the longest period of treatment for all tissues examined, as the usual duration of treatment in animal studies is between 15-30 days.…”
Section: The Role Of Lithium Dosementioning
confidence: 99%
“…No longer-term lithium treatment was investigated, as in studies concerning lithium effects in rat brain, the usual duration of treatment is between 15-30 days [47,49,53,55]. In all cases investigated, severe structural abnormalities in collagen fibrils are found [26].…”
Section: Lithium Effects On Rat Cranial Arachnoid and Dura Mater Collmentioning
confidence: 99%