Abstract:Cholinesterase (EC 3.1.1.8) for intravenous use has been obtained from fraction
IV, a by-product of ethanol fractionation. A four-step procedure has been developed
associating precipitation by Rivanol® and PEG 4000 with chromatography on DEAE-cellulose.
The yield corresponds to 30-35% of the activity found in fraction IV. Vials containing
5000 U of CHE stabilized by 2.5% albumin have been prepared. The pyrogen-free
product is well tolerated in the human.
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