SIgA–Shigella Immune Complexes Interact with Dectin-1 and SIGNR3 to Differentially Regulate Mouse Peyer's Patch and Mesenteric Lymph Node Dendritic Cell's Responsiveness

Mikulic, Josip; Bioley, Gilles; Corthésy, Blaise

doi:10.1016/j.jmb.2017.05.024

Cited by 9 publications

(12 citation statements)

References 53 publications

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“…Uptake of SIgA-immune complexes by mouse or human DCs is mediated via specific intercellular adhesion molecule-3 grabbing non-integrin receptor (SIGNR) 1 or the human homolog DC-SIGN, respectively [ 96 , 97 ]. SIgA-immune complexes can further bind to murine intestinal DCs via Dectin-1, and SIGNR3 [ 98 ]. Uptake of SIgA alone or SIgA-immune complexes by DCs is critical for dampening inflammatory immune responses in the intestinal mucosa and in turn intestinal homeostasis.…”

Section: Sig-mediated Immune Modulation During Infectionmentioning

confidence: 99%

“…These DCs further induced the expansion of Foxp3+ regulatory T cells via IL-10 and TGF-β secretion in vitro and in vivo [ 96 ]. Furthermore, Shigella flexneri :SIgA immune complexes reduced expression of pro-inflammatory molecules by DCs and epithelial monolayers in vitro compared to the bacterium alone [ 77 , 98 ]. Importantly, Peyer’s patches exposed to Shigella flexneri :SIgA immune complexes showed reduced induction of inflammatory mediators and tissue damage as compared to bacteria alone [ 76 ].…”

Section: Sig-mediated Immune Modulation During Infectionmentioning

confidence: 99%

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The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

Turula

Wobus

2018

Viruses

139

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The gastrointestinal tract houses millions of microbes, and thus has evolved several host defense mechanisms to keep them at bay, and prevent their entry into the host. One such mucosal surface defense is the secretion of secretory immunoglobulins (SIg). Secretion of SIg depends on the polymeric immunoglobulin receptor (pIgR), which transports polymeric Ig (IgA or IgM) from the basolateral surface of the epithelium to the apical side. Upon reaching the luminal side, a portion of pIgR, called secretory component (SC) is cleaved off to release Ig, forming SIg. Through antigen-specific and non-specific binding, SIg can modulate microbial communities and pathogenic microbes via several mechanisms: agglutination and exclusion from the epithelial surface, neutralization, or via host immunity and complement activation. Given the crucial role of SIg as a microbial scavenger, some pathogens also evolved ways to modulate and utilize pIgR and SIg to facilitate infection. This review will cover the regulation of the pIgR/SIg cycle, mechanisms of SIg-mediated mucosal protection as well as pathogen utilization of SIg.

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Section: Sig-mediated Immune Modulation During Infectionmentioning

confidence: 99%

Section: Sig-mediated Immune Modulation During Infectionmentioning

confidence: 99%

The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

Turula

Wobus

2018

Viruses

139

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“…By using the inflammatory human pathogen Shigella flexneri, it was identified that that a subset of subepithelial dome DCs can be differentially conditioned by sIgA. Cross-species antibodies ll were identified to be bound by Dectin-1 and SIGNR3 receptors on DCs that are known to recognize carbohydrate motifs (Mikulic et al, 2017a). This recognition induced internalization of the sIgA-S. flexneri complex into DCs.…”

Section: Siga Aids Colonization Of Some Commensalsmentioning

confidence: 99%

Microbiota-antibody interactions that regulate gut homeostasis

Weis

Round

2021

Cell Host & Microbe

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“…Indeed nasal vaccination of mice with a fusion of an anti-CD205 antibody and the HIV p24 antigen, elicited HIV-specific effector and memory T cell responses locally and at distant mucosal sites including the gut . Recently, the receptors Dectin-1 and SIGNR3 expressed on intestinal CD11c + CD11b + MHCII + F4/80 – CD8 – DCs were reported to bind SIgA and led to uptake of bacteria coated with SIgA into these cells . Consequently, SIgA used as a carrier for mucosal vaccine delivery could also help to target DCs in mucosal tissues.…”

Section: Ligand-mediated Vaccine Delivery Systemsmentioning

confidence: 99%

Targeted Strategies for Mucosal Vaccination

2018

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Mucosal immune responses are in the first line of defense against most infections and protective mucosal immunity can be achieved by mucosal vaccination. However, mucosal tolerance and physicochemical features of the mucosal environment pose challenging obstacles to the development of mucosal vaccines. Vaccine formulations must be designed to enhance stability at the mucosae and incorporate features that induce innate immunity at mucosal inductive sites. To face these challenges, a number of novel delivery systems for targeting of mucosal vaccines to specific mucosal locations have been developed. In addition, specific mucosal immune cell targeting can potentially be achieved with ligand-antigen bioconjugates, in particular, those directed to specific receptors expressed on Microfold (M) cells, mucosal epithelial cells, or mucosal antigen presenting cells (APCs). In this topical review, targeted strategies to enhance the effectiveness of mucosal vaccines are addressed, and obstacles to the design and progression of effective ligand-mediated mucosal vaccines are highlighted.

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SIgA–Shigella Immune Complexes Interact with Dectin-1 and SIGNR3 to Differentially Regulate Mouse Peyer's Patch and Mesenteric Lymph Node Dendritic Cell's Responsiveness

Cited by 9 publications

References 53 publications

The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

Microbiota-antibody interactions that regulate gut homeostasis

Targeted Strategies for Mucosal Vaccination

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