sIgG4 and Other Tolerance Predictors at Food Allergy in Early Age Children

Деев, А Д; Петровская, Игоревна; Namazova-Baranova, S Leyla; Makarova, G Svetlana; Зубкова, Array В.; Maianskiĭ, A N

doi:10.15690/pf.v12i3.1352

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…С целью дифференциальной диагностики с первичной гипо-и алактазией и исключения/подтверждения данных заболеваний проводится анализ полиморфизмов в гене лактазы (LCT) [33,34]. Для оценки сенсибилизации не рекомендовано проведение анализа уровня специфических IgG и IgG4 к пищевым белкам в связи с его неинформативностью [2,35].…”

Section: дополнительные диагностические исследованияunclassified

Modern Principles of Managing Children with Food Allergies

et al. 2021

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The article presents modern data on the epidemiology, etiology and clinical manifestations of food allergies in children. Evidence-based approaches to diagnosis, including differential, treatment, and prevention of food allergies in children are shown. Patient management tactics and algorithms are presented in detail. The guidelines are based on all available up-to-date data on food allergies. The material is based on the methodological guideline for the management of patients with food allergies previously developed by expert specialists of the Union of Pediatricians of Russia in 2021.

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Section: дополнительные диагностические исследованияunclassified

Modern Principles of Managing Children with Food Allergies

et al. 2021

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“…В учебниках по аллергологии и иммунологии и научной литературе антитела класса G описываются как блоки-рующие антитела, характеризующие нормальный иммун-ный ответ на антиген [11,12]. В недавнем исследовании, проведенном в МНИЦ здоровья детей (Москва), было показано, что уровни специфических IgG4 к пищевым белкам у детей без пищевой аллергии значимо выше, чем у детей этого же возраста с пищевой аллергией [13]. А дальнейшее наблюдение за группой детей с пищевой аллергией позволило установить, что пациенты, кото-рые имели изначально высокие уровни антител клас-са IgG4 к белкам коровьего молока, быстрее формиро-вали толерантность к этому продукту.…”

Section: Introductionunclassified

Twelve Myths About Food Allergies in Children

Макарова¹

2017

Vopr. sovr. pediatr.

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Health and growth indices in children with cow’s milk protein allergy depending on oral tolerance development

Galimova¹,

Емельяшенков²,

Макарова

et al. 2020

Medicinskij alfavit

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Relevance. Dairy-free diet is the basis of cow’s milk allergy (CMA) patient’s management. Duration of the diet is individual, but some children don’t develop tolerance.The aim of the study was to investigate health and growth indices in children with CMA depending on tolerance development by the age of five. Materials and methods. 153 children from 1 to 18 months with diagnosed CMA were included in the prospective study (76.5% with IgE-mediated form). The tolerance was determined after 6–12 months of a milk-free diet and at the age of 5 using an open challenge test. Anthropometry indices (Anthro Plus), levels of specific IgE (Immuno CAP 250) and IgG4 (ELISA) to dietary proteins and the presence of allergic diseases in children also were assessed.Results. 50.3% of children developed tolerance to cow’s milk protein after 6–12 months of a milk-free diet. By the age of 5 63.3% of patients had complete tolerance of dairy products. Partially formed tolerance was observed in 22.9%. 13.8% of patients still had clinical reactions to cow’s milk proteins. Patients with persistent CMA typically had IgE-mediated form, lower growth indices and multiple allergic pathology.Conclusion. The consideration of tolerance development predictors can allow to personalize the management of CMA. Additional researches are needed to clarify the causes of growth indices decline in children with persistent CMA.

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sIgG4 and Other Tolerance Predictors at Food Allergy in Early Age Children

Cited by 3 publications

References 5 publications

Modern Principles of Managing Children with Food Allergies

Modern Principles of Managing Children with Food Allergies

Twelve Myths About Food Allergies in Children

Health and growth indices in children with cow’s milk protein allergy depending on oral tolerance development

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