Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils

Selvatici, Rita; Falzarano, Sofia; Mollica, Adriano; Spisani, Susanna

doi:10.1016/j.ejphar.2006.01.034

Cited by 173 publications

(133 citation statements)

References 75 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…12 Formyl-methionyl-leucylphenylalanine is a formyl peptide derivative obtained from bacterial metabolites or derived from disrupted mitochondria. 13 Both PAF and fMLP are chemoattractants that bind to the neutrophil cell surface via members of the membrane-spanning GTP-binding protein (G protein) linked receptor family. [12][13][14] Platelet activating factor and fMLP have common and distinct signalling pathways in neutrophils.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Persistance et voie de l’inhibition de la production de superoxyde par les neutrophiles induite par isoflurane

Saad

Eom

et al. 2009

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Background Our previous work has demonstrated that treatment with isoflurane has a preconditioning-like inhibitory effect on superoxide production (SOP) by polymorphonuclear neutrophils. The current objectives were to determine persistency of this effect and to clarify where in the signalling pathway this inhibition of SOP occurred. The latter was accomplished using two receptor-dependent neutrophil agonists, platelet activating factor (PAF) and formyl-methionyl-leucyl-phenylalanine (fMLP), and two receptor-independent neutrophil stimuli, the protein-kinase C stimulator, phorbol myristate acetate (PMA), and the calcium ionophore, A23187.Methods Arterial blood samples were obtained from eight dogs under baseline condition (conscious state), during isoflurane (1 MAC) administration, and 24 and 48 hr post-isoflurane (also in conscious state). Neutrophils were isolated and stimulated with 1 lM concentrations of PAF, fMLP, PMA, and A23187. SOP was measured spectrophotometrically. Results Isoflurane administration caused (1) an approximate 50% decrease in SOP during PAF or fMLP (P \ 0.01 vs baseline), which remained evident from 24 to 48 hr following isoflurane; (2) an initial 29% decrease in SOP during PMA (P \ 0.05 vs baseline), which returned to baseline by 24 hr following isoflurane; and (3) no change in SOP during A23187 (P [ 0.05 vs baseline). Conclusions Isoflurane administration caused prolonged (from 24 to 48 hr) decreases in agonist-induced SOP by neutrophils. This effect involved inhibition at site(s)

show abstract

Section: Discussionmentioning

confidence: 99%

“…13 Both PAF and fMLP are chemoattractants that bind to the neutrophil cell surface via members of the membrane-spanning GTP-binding protein (G protein) linked receptor family. [12][13][14] Platelet activating factor and fMLP have common and distinct signalling pathways in neutrophils. 14 The main common pathways are as follows.…”

Section: Discussionmentioning

confidence: 99%

Persistance et voie de l’inhibition de la production de superoxyde par les neutrophiles induite par isoflurane

Saad

Eom

et al. 2009

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

show abstract

“…Cells with chemotactic functions are able to sense slight changes in the concentration of a chemoattractant, sensing changes 1% over the length of a single cell (8-12 µm) (119,122). Once the neutrophils encounter a high concentration of chemoattractants, they further initiate the process of phagocytosis and killing (118).…”

Section: Fusobacterium Nucleatum (F Nucleatum) and Aggregatibacter mentioning

confidence: 99%

“…They can respond to signals from both intermediary chemoattractants (IL-8, platelet activated factor, chemotactic cytokines, leukotriene B 4 (LTB4)) and end target cellular chemoattractants (formyl-methionylleucyl phenylalanine (fMLF), complement fragment C5a, C3a, plasminogen activator), which guide them to a generalized region and then further to a more specific site, where they will encounter their target (118)(119)(120)123). Ultimately, neutrophils will dissociate from the intermediary chemoattractants and migrate toward the end-target chemoattractants of bacterial origin (119,125).…”

Section: Fusobacterium Nucleatum (F Nucleatum) and Aggregatibacter mentioning

confidence: 99%

“…Directional movement of leukocytes is necessary for a functional response to a variety of inflammatory signals (117). Leukocytes participate in directional movement toward sites of injury and inflammation by deciphering a chemoattractant gradient, a process referred to as chemotaxis (114,(117)(118)(119)(120).…”

Section: Fusobacterium Nucleatum (F Nucleatum) and Aggregatibacter mentioning

confidence: 99%

See 1 more Smart Citation

Characterization of Filifactor alocis and its immune evasion strategies employed against human neutrophils.

Armstrong¹

View full text Add to dashboard Cite

Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs

Koumantou,

Adiko,

Bourdely

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Cross‐presentation by MHCI is optimally efficient in type 1 dendritic cells (DC) due to their high capacity for antigen processing. However, through specific pathways, other DCs, such as type 2 DCs and inflammatory DCs (iDCs) can also cross‐present antigens. FcγR‐mediated uptake by type 2 DC and iDC subsets mediates antibody‐dependent cross‐presentation and activation of CD8+ T cell responses. Here, an important role for the p84 regulatory subunit of PI3Kγ in mediating efficient cross‐presentation of exogenous antigens in otherwise inefficient cross‐presenting cells, such as type 2 DCs and GM‐CSF‐derived iDCs is identified. FcγR‐mediated cross‐presentation is shown in type 2 and iDCs depend on the enzymatic activity of the p84/p110γ complex of PI3Kγ, which controls the activity of the NADPH oxidase NOX2 and ROS production in murine spleen type 2 DCs and GM‐CSF‐derived iDCs. In contrast, p84/p110γ is largely dispensable for cross‐presentation by type 1 DCs. These findings suggest that PI3Kγ‐targeted therapies, currently considered for oncological practice, may interfere with the ability of type 2 DCs and iDCs to cross‐present antigens contained in immune complexes.

show abstract

Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils

Cited by 173 publications

References 75 publications

Persistance et voie de l’inhibition de la production de superoxyde par les neutrophiles induite par isoflurane

Persistance et voie de l’inhibition de la production de superoxyde par les neutrophiles induite par isoflurane

Characterization of Filifactor alocis and its immune evasion strategies employed against human neutrophils.

Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs

Contact Info

Product

Resources

About