Signaling Pathways in the Activation of Mast Cells Cocultured with Astrocytes and Colocalization of Both Cells in Experimental Allergic Encephalomyelitis

Kim, Dae Yong; Jeoung, Dooil; Ro, Jai Youl

doi:10.4049/jimmunol.1000991

Cited by 56 publications

(67 citation statements)

References 60 publications

(73 reference statements)

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“…Cultures were maintained in 5% CO 2 at 37°C. Bone marrow-derived mouse mast cells were isolated and cultured according to the standard procedures (20).…”

Section: Methodsmentioning

confidence: 99%

Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein

Kim¹,

Kim²,

Park³

et al. 2012

Journal of Biological Chemistry

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“…Cultures were maintained in 5% CO 2 at 37°C. Bone marrow-derived mouse mast cells were isolated and cultured according to the standard procedures (20).…”

Section: Methodsmentioning

confidence: 99%

Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein

Kim¹,

Kim²,

Park³

et al. 2012

Journal of Biological Chemistry

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“…Astrocyte-derived cytokines/chemokines trigger mast cell degranulation [128]. Co-culture of mouse bone marrow mast cells with cortical astrocytes evidenced autocrine/paracrine actions, with release of histamine and leukotrienes [129]; mast cells and astrocytes displayed enhanced surface expression of CD40L and CD40, respectively, whose crosstalk led to the production of inflammatory cytokines [130].…”

Section: Mast Cells and Glia: Are You Talking To Me?mentioning

confidence: 99%

Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide

Skaper

Facci

2012

Phil. Trans. R. Soc. B

101

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Communication between the immune and nervous systems depends a great deal on pro-inflammatory cytokines. Both astroglia and microglia, in particular, constitute an important source of inflammatory mediators and may have fundamental roles in central nervous system (CNS) disorders from neuropathic pain and epilepsy to neurodegenerative diseases. Glial cells respond also to pro-inflammatory signals released from cells of immune origin. In this context, mast cells are of particular relevance. These immune-related cells, while resident in the CNS, are able to cross a compromised bloodspinal cord and blood-brain barrier in cases of CNS pathology. Emerging evidence suggests the possibility of mast cell-glia communication, and opens exciting new perspectives for designing therapies to target neuroinflammation by differentially modulating the activation of non-neuronal cells normally controlling neuronal sensitization-both peripherally and centrally. This review aims to provide an overview of recent progress relating to the pathobiology of neuroinflammation, the role of glia, neuro-immune interactions involving mast cells and the possibility that glia-mast cell interactions contribute to exacerbation of acute symptoms of chronic neurodegenerative disease and accelerated disease progression, as well as promotion of pain transmission pathways. Using this background as a starting point for discussion, we will consider the therapeutic potential of naturally occurring fatty acid ethanolamides, such as palmitoylethanolamide in treating systemic inflammation or blockade of signalling pathways from the periphery to the brain in such settings.

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“…Luteolin inhibits myelin basic protein-induced human mast cell activation and mast celldependent stimulation of Jurkat T cells (Theoharides et al 2008) and luteolin along with other structurally related flavonoids inhibit experimental allergic encephalomyelitis in rodents (Theoharides 2009). Mast cells along with astrocytes are increased in the thalamic border region of the habenula in experimental allergic encephalomyelitis model (Kim et al 2010). Activation of mast cells in association with astrocytes induces release of mediators by small GTPases/Ca 2+ influx to participate in the pathophysiology of chronic neurodegenerative inflammatory diseases such as multiple sclerosis (Kim et al 2010).…”

Section: Multiple Sclerosismentioning

confidence: 99%

“…Mast cells along with astrocytes are increased in the thalamic border region of the habenula in experimental allergic encephalomyelitis model (Kim et al 2010). Activation of mast cells in association with astrocytes induces release of mediators by small GTPases/Ca 2+ influx to participate in the pathophysiology of chronic neurodegenerative inflammatory diseases such as multiple sclerosis (Kim et al 2010).…”

Section: Multiple Sclerosismentioning

confidence: 99%

Mast cells: an expanding pathophysiological role from allergy to other disorders

Anand

Singh

Jaggi

et al. 2012

Naunyn-Schmiedeberg's Arch Pharmacol

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The mast cells are multi-effector cells with wide distribution in the different body parts and traditionally their role has been well-defined in the development of IgE-mediated hypersensitivity reactions including bronchial asthma. Due to the availability of genetically modified mast cell-deficient mice, the broadened pathophysiological role of mast cells in diverse diseases has been revealed. Mast cells exert different physiological and pathophysiological roles by secreting their granular contents, including vasoactive amines, cytokines and chemokines, and various proteases, including tryptase and chymase. Furthermore, mast cells also synthesize plasma membrane-derived lipid mediators, including prostaglandins and leukotrienes, to produce diverse biological actions. The present review discusses the pathophysiological role of mast cells in different diseases, including atherosclerosis, pulmonary hypertension, ischemia-reperfusion injury, male infertility, autoimmune disorders such as rheumatoid arthritis and multiple sclerosis, bladder pain syndrome (interstitial cystitis), anxiety, Alzheimer's disease, nociception, obesity and diabetes mellitus.

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Signaling Pathways in the Activation of Mast Cells Cocultured with Astrocytes and Colocalization of Both Cells in Experimental Allergic Encephalomyelitis

Abstract: Material

Cited by 56 publications

References 60 publications

Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein

Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein

Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide

Mast cells: an expanding pathophysiological role from allergy to other disorders

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