Signalling pathways involved in oocyte growth, acquisition of competence and activation

Nunes, Cláudia; Silva, Vladimiro; Torgal, Isabel; Fardilha, Margarida

doi:10.3109/14647273.2015.1006692

Cited by 23 publications

(22 citation statements)

References 60 publications

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“…An increase of intraoocyte ROS level associates with the decrease of cAMP during meiotic resumption from diplotene arrest (Cheon et al, ; Chaube, ; Pandey and Chaube, ; Nunes et al, ; Tiwari and Chaube, ). Our study suggests that the decrease of intraoocyte cAMP level and increased Ca ++ level induce generation of ROS in rat oocytes cultured in vitro (Prasad et al, ).…”

Section: Role Of Ca++ In Meiotic Resumption From Diplotene Arrestmentioning

confidence: 99%

“…The destabilized MPF finally results in spontaneous exit from M‐II arrest (Madgwick and Jones, ; Premkumar and Chaube, ). The increased ROS level associates with the decreased level of cAMP (Cheon et al, ; Nunes et al, ; Prasad et al, ; Premkumar and Chaube, ). The increased ROS level and decreased cAMP level trigger specific phosphorylation status of Cdk1 and cyclin B1 degradation that results in MPF destabilization (Markoulaki et al, ; Prasad et al, ; Premkumar and Chaube, ) (Fig.…”

Section: Role Of Ca++ In Meiotic Resumption From Diplotene Arrestmentioning

confidence: 99%

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Calcium Signaling During Meiotic Cell Cycle Regulation and Apoptosis in Mammalian Oocytes

Tiwari

Prasad

Shrivastav

et al. 2016

Journal Cellular Physiology

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Calcium (Ca ) is one of the major signal molecules that regulate various aspects of cell functions including cell cycle progression, arrest, and apoptosis in wide variety of cells. This review summarizes current knowledge on the differential roles of Ca in meiotic cell cycle resumption, arrest, and apoptosis in mammalian oocytes. Release of Ca from internal stores and/or Ca influx from extracellular medium causes moderate increase of intracellular Ca ([Ca ]i) level and reactive oxygen species (ROS). Increase of Ca as well as ROS levels under physiological range trigger maturation promoting factor (MPF) destabilization, thereby meiotic resumption from diplotene as well as metaphase-II (M-II) arrest in oocytes. A sustained increase of [Ca ]i level beyond physiological range induces generation of ROS sufficient enough to cause oxidative stress (OS) in aging oocytes. The increased [Ca ]i triggers Fas ligand-mediated oocyte apoptosis. Further, OS triggers mitochondria-mediated oocyte apoptosis in several mammalian species. Thus, Ca exerts differential roles on oocyte physiology depending upon its intracellular concentration. A moderate increase of [Ca ]i as well as ROS mediate spontaneous resumption of meiosis from diplotene as well as M-II arrest, while their high levels cause meiotic cell cycle arrest and apoptosis by operating both mitochondria- as well as Fas ligand-mediated apoptotic pathways. Indeed, Ca regulates cellular physiology by modulating meiotic cell cycle and apoptosis in mammalian oocytes. J. Cell. Physiol. 232: 976-981, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Role Of Ca++ In Meiotic Resumption From Diplotene Arrestmentioning

confidence: 99%

Section: Role Of Ca++ In Meiotic Resumption From Diplotene Arrestmentioning

confidence: 99%

Calcium Signaling During Meiotic Cell Cycle Regulation and Apoptosis in Mammalian Oocytes

Tiwari

Prasad

Shrivastav

et al. 2016

Journal Cellular Physiology

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“…COX inhibition can also block blastocyst development, which suggests that COX and its products are involved in early embryonic development (18). In addition, PGE 2 , PGI 2 , PGF 2 α , PGD 2 , and 15-deoxy-Δ 12,14 -PG J 2 also play major roles in follicular/oocyte development, ovulation, and fertilization (19–23). Furthermore, PGs are involved in the chronic inflammation that develops alongside the metabolic disorders associated with PCOS and obesity.…”

mentioning

confidence: 99%

Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production?

Li¹,

Chu²,

Ma³

et al. 2016

The Journal of Clinical Endocrinology & Metabolism

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“…In the context of reproduction (see below), mainly activation of MAPK pathways (e.g., ERK1/2, p38, or JNK) has been investigated so far, probably because MAPK activation is of great importance in reproduction (Li et al, 2009; Almog and Naor, 2010; Fan et al, 2012; Nunes et al, 2015). However, CaSR can also induce other pathways such as the PI-3K/AKT pathway (Bilderback et al, 2002; Liao et al, 2006) in the reproductive system.…”

Section: The Calcium Sensing Receptor Casr and Its Functional Versamentioning

confidence: 99%

The Calcium-Sensing Receptor and the Reproductive System

Ellinger

2016

Front. Physiol.

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Active placental transport of maternal serum calcium (Ca2+) to the offspring is pivotal for proper development of the fetal skeleton as well as various organ systems. Moreover, extracellular Ca2+ levels impact on distinct processes in mammalian reproduction. The calcium-sensing receptor (CaSR) translates changes in extracellular Ca2+-concentrations into cellular reactions. This review summarizes current knowledge on the expression of CaSR and its putative functions in reproductive organs. CaSR was detected in placental cells mediating materno-fetal Ca2+-transport such as the murine intraplacental yolk sac (IPYS) and the human syncytiotrophoblast. As shown in casr knock-out mice, ablation of CaSR downregulates transplacental Ca2+-transport. Receptor expression was reported in human and rat ovarian surface epithelial (ROSE) cells, where CaSR activation stimulates cell proliferation. In follicles of various species a role of CaSR activation in oocyte maturation was suggested. Based on studies in avian follicles, the activation of CaSR expressed in granulosa cells may support the survival of follicles after their selection. CaSR in rat and equine sperms was functionally linked to sperm motility and sperm capacitation. Implantation involves complex interactions between the blastocyst and the uterine epithelium. During early pregnancy, CaSR expression at the implantation site as well as in decidual cells indicates that CaSR is important for blastocyst implantation and decidualization in the rat uterus. Localization of CaSR in human extravillous cytotrophoblasts suggests a role of CaSR in placentation. Overall, evidence for functional involvement of CaSR in physiologic mammalian reproductive processes exists. Moreover, several studies reported altered expression of CaSR in cells of reproductive tissues under pathologic conditions. However, in many tissues we still lack knowledge on physiological ligands activating CaSR, CaSR-linked G-proteins, activated intracellular signaling pathway, and functional relevance of CaSR activation. Clearly, more work is required in the future to decode the complex physiologic and pathophysiologic relationship of CaSR and the mammalian reproductive system.

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Signalling pathways involved in oocyte growth, acquisition of competence and activation

Cited by 23 publications

References 60 publications

Calcium Signaling During Meiotic Cell Cycle Regulation and Apoptosis in Mammalian Oocytes

Calcium Signaling During Meiotic Cell Cycle Regulation and Apoptosis in Mammalian Oocytes

Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production?

The Calcium-Sensing Receptor and the Reproductive System

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