Signet Ring Cell Primary Cutaneous CD30+ Lymphoproliferative Disorder Presenting as a Monomorphic T-Cell Posttransplant Lymphoproliferative Disease

Papalas, John A.; Kulbacki, Evan; Park, H.; Howell, Eric

doi:10.1097/dad.0b013e3182513344

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2016

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“…Additionally, this case had a unique feature of signet ring cells in the histologic findings. 8 In cases of cutaneous signet cell T cell lymphoma that have been previously noted, multi-vesicular bodies have been thought to be the reasoning behind the signet ring appearance. 9 It is postulated that signet ring cell formation is the result of membrane recycling.…”

Section: Discussionmentioning

confidence: 96%

CD30+ Primary Cutaneous Post-Transplant Lymphoproliferative Disorder with Signet-Ring Cell Features

Malviya¹,

Wickless²

2016

Hematology Reports

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We report a case of primary cutaneous CD30+ post-transplant lymphoproliferative disorder with an uncommon finding of signet ring cell features in a heart transplant patient. The neoplastic cells were CD4 and CD30 positive, and negative for S-100, pancytokeratin, myeloperoxidase, and CD56. In situ hybridization for Epstein Barr Virus (EBV) was negative, even though the patient did have EBV viremia.

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Section: Discussionmentioning

confidence: 96%