Signet-ring Cells Associated with Pseudomembranous Colitis

Schiffman, Raymond

doi:10.1097/00000478-199605000-00006

Cited by 35 publications

(24 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because this is also the most common location of signet-ring cell adenocarcinoma, a high risk of overdiagnosis exists. Signet-ring cells mimicking adenocarcinoma have been found in ischemic ileitis, Peutz-Jeghers polyps, ulcerated tubular adenomas of the colon, and pseudomembranous colitis [33,[37][38][39][40][41][42][43]. In the latter condition, they have been said to occur in as many as one quarter of the cases [1].…”

Section: Discussionmentioning

confidence: 99%

“…Breast [3] Large bowel [4] Appendix [5] Bladder, ureter, and pelvis [6] Ampulla of Vater [7] Esophagus [8] Prostate [9] Lung [10] Salivary glands [11] Sinonasal tract [12] Uterine cervix [13] Uterine corpus [14] Ovary (questionable) [15] Other neoplastic conditions Malignant lymphoma [16] Malignant melanoma [17] Basal cell carcinoma of skin [18] Squamous cell carcinoma of skin [19] Stromal tumor of ovary [20] Chondrosarcoma [21] Ependymoma [22] Malignant mesothelioma [23] Meningioma [24] Collecting duct carcinoma of kidney [25] Urothelial carcinoma of renal pelvis with collagenous spherulosis [26] Follicular adenoma and carcinoma of thyroid [27] Salivary gland adenoma [28] Pituitary adenoma [29] Carcinoid tumor of gallbladder [30] Pancreatic endocrine neoplasm [31] GIST [32] Peutz-Jeghers polyps [33] Epithelioid leiomyoma [34] Gastric schwannoma [35] Testicular seminoma [36] Nonneoplastic conditions Inflammatory/necrotizing conditions of gastrointestinal tract and gallbladder [33,[37][38][39][40][41][42][43]…”

Section: Casementioning

confidence: 99%

See 1 more Smart Citation

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

2009

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Casementioning

confidence: 99%

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

2009

View full text Add to dashboard Cite

“…14,23 This phenomenon of benign cells rounding up and taking the shape of signet rings after they are damaged and desquamated has been reported in pseudomembranous colitis. 1,5,18,19 Chen 4 had observed signet-ring cell-like change in PeutzJeghers polyps, and postulated that they result from torsion and mucosal ischemia, whereas others have attributed the changes to a necrotizing process and ulceration. 22 Signetring cell changes have also been reported in the setting of acute erosive gastropathy.…”

Section: Discussionmentioning

confidence: 99%

Post-Gastric Endoscopic Mucosal Resection Surveillance Biopsies: Evaluation of Mucosal Changes and Recognition of Potential Mimics of Residual Adenocarcinoma

Mitsuhashi

Lauwers²,

Ban³

et al. 2006

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Endoscopic mucosal resection (EMR) offers curative treatment for patients with node-negative early gastric carcinoma of less than 2 cm without ulceration or ulceration scar. Follow-up biopsies are frequently performed to ensure the absence of residual neoplasia. We performed a retrospective analysis of post-EMR biopsies from 33 patients who underwent gastric EMR. Histologic changes included inflammation (100%), stromal edema (97.0%), foveolar hyperplasia (78.8%), ectatic vessels (66.7%), epithelial atypia (60.6%), increased glandular mitoses (57.6%), epithelial anisonucleosis (54.5%), fibrinopurulent materials (51.5%), ischemia (48.5%), stromal hemorrhage (33.3%), mucin depletion (12.1%), clear cell degeneration (15.2%), and signet-ring cell-like change (6.1%). Especially, clear cell degeneration and signet-ring cell-like change were conspicuous in the area of ischemia. Residual adenocarcinomas were noted in 4 of 33 cases, and consistently showed high nuclear-to-cytoplasmic ratio with high glandular density. Glandular clear cell degeneration and/or signet-ring cell-like change were worrisome and sometimes difficult to be distinguished from residual neoplastic glands. However, these degenerative glands were usually embedded in a nondesmoplastic stroma and showed anisonucleosis of glandular epithelia. Mimics of residual adenocarcinoma, namely clear cell degeneration and signet-ring cell-like change should be judiciously assessed to avoid unnecessary surgery.

show abstract

“…In the mucus-secreting epithelia, the secretion, in some cases, tends to become trapped between the mucosal folds, leading to displacement of epithelium, and this may be the source of bizarre histologic appearances. The sloughed epithelial cells accumulate in mucosal folds in which the surface openings are obstructed and may assume a signet ring appearance [17,18]. The signet-ring cells are confined to the surface epithelium and glandular lumina.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma of the Uterine Cervix with Massive Signet-Ring Cell Differentiation

Mayorga¹,

García-Valtuille²,

Fernández³

et al. 1997

Int J Surg Pathol

View full text Add to dashboard Cite

Primary signet-ring cell adenocarcinoma of the cervix is very rare and less common than metastatic signet-ring cell adenocarcinoma. To the best of the authors' knowledge only one genuine case has been reported to date. Tvvo cases of primary signetring cell adenocarcinoma of the uterine cervix in patients aged 68 and 74 years are presented. The tumors were in stage IB. The light microscopic findings were confirmed by histochemical and immunohistochemical study. DNA nuclear analysis by flow cytometry of the neoplasms revealed an aneuploid (tetraploid) pattern. The patients had no evidence of recurrent or metastatic disease 35 and 25 months after a radical hysterectomy with bilateral salpingo-oophorectomy and lymph node dissection respectively. Primary signet-ring cell adenocarcinoma of the cervix should be differentiated from metastatic adenocarcinoma, endocervical involvement by signetring cell carcinoma of the endometrium, benign mucin-filled signet-ring cell aggregates that may accumulate in mucosal folds, microglandular hyperplasia, mucicarminophilic histiocytosis, and other malignant neoplasms that may have signet ring-like cells and deserve consideration such as squamous cell carcinoma, malignant lymphoma, myeloma, and malignant melanoma. Although very rare, signetring cell adenocarcinoma of the cervix can exist as a primary tumor. Distinction between a primary neoplasm and a metastasis to the cervix is decisive for treatment and prognosis. Int J Surg Pathol 5(3/4): [95][96][97][98][99][100] 1997 Adenocarcinomas of the uterine cervix at present account for from 10% to 20% of invasive carcinomas of the cervix in developed countries [1,2]. This apparent increased frequency of adenocarcinomas results from a decrease in the incidence of the invasive squamous cell carcinoma and a real absolute increment of the glandular tumors [3]. Although less common than squamous cell carcinomas, adenocarcinomas are far more difficult to diagnose in the

show abstract

Signet-ring Cells Associated with Pseudomembranous Colitis

Cited by 35 publications

References 7 publications

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

Post-Gastric Endoscopic Mucosal Resection Surveillance Biopsies: Evaluation of Mucosal Changes and Recognition of Potential Mimics of Residual Adenocarcinoma

Adenocarcinoma of the Uterine Cervix with Massive Signet-Ring Cell Differentiation

Contact Info

Product

Resources

About