Significance of penile hypersensitivity in premature ejaculation

Abstract

To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete the self-report intravaginal ejaculation latency time (IELT) by stopwatch. According to the IELT, the subjects were classified into 3 groups. Vibratory thresholds were recorded at the glans penis and penile shaft using a biothesiometer. We found that vibratory thresholds in the glans penis and penile shaft were significantly lower in both mild and severe PE group than in the control group (3.81 ± 0.57 and 3.54 ± 0.43 vs 4.73 ± 0.77 for glans penis p = 0.000; 3.64 ± 0.52 and 3.37 ± 0.50 vs 4.62 ± 0.69 for penile shaft p = 0.002). The vibratory threshold decreased as the disease aggravated. In the mild and severe PE groups, a significant positive correlation was detected between the mean values of IELT and the vibratory thresholds. Furthermore, in the receiver operating characteristics curve analysis, the area under the curve of the glans penis and penile shaft vibratory thresholds predicting severe PE were 0.852 and 0.893 respectively. Our study established a dose-dependent association between penile vibratory threshold and PE. Therefore, the vibratory threshold can serve as a potential marker for predicting the severity of PE.

Significance of piezo‐type mechanosensitive ion channel component 2 in premature ejaculation: An animal study

“…A recent study did not detect any significant difference in penile sensitivity between men with or without premature ejaculation or delay ejaculation . However, our previous study also confirmed the sensitization of penile sensation with a relative large sample size . The mechanism of peripheral nerve sensitization in the penis is also indicated by the effectiveness of local anesthetics in the treatment of premature ejaculation .…”

Significance of blood lipid parameters as effective markers for arteriogenic erectile dysfunction

“…Blood tests were performed for each participant including hormone profile values, fasting blood glucose, and lipids. Laboratory examinations were conducted at the laboratory of the Second Hospital of Shandong University, using a biochemical analyzer (Modular Analytics, Roche, Mannheim, Germany) . Blood samples from each participant were collected from the antecubital vein at 8:00 AM after 12 hours of fasting, and then, all samples were drawn into tubes coated with ethylene diamine tetraacetic acid (EDTA).…”

Application of micronised acellular dermal matrix for primary premature ejaculation: A preliminary study

“…The increased sensitivity of the penis significantly reduces the IELT, further leading to PE. Our previous clinical research showed that penile hypersensitivity was a factor contributing to short intravaginal ejaculation latencies (Guo et al., 2017). Many studies have attempted to treat PE by reducing penile hypersensitivity (Dai et al., 2019; Liu et al., 2019).…”