Significance of predischarge BNP on one-year outcome in decompensated heart failure—comparative study with echo-Doppler indexes

Hamada, Yoshimasa; Tanaka, Nobuaki; Murata, Kazuya; Takaki, Akira; Wada, Yasuaki; Oyama, Rikimaru; Liu, Jinyao; Harada, Naohiko; Okuda, Shinichi; Hadano, Yasuyuki; Matsuzaki, Masunori

doi:10.1016/j.cardfail.2004.05.001

Cited by 28 publications

(18 citation statements)

References 21 publications

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“…This has been reported previously both in the hospital [6][7][8][14][15][16] as well as in the ambulatory setting [17][18][19]. Our data confirm these findings, showing that NTproBNP three months after discharge is a better prognostic marker than NT-proBNP at discharge.…”

Section: Discussionsupporting

confidence: 92%

Prognostic value of sequential measurements of amino‐terminal prohormone of B‐type natriuretic peptide in ambulatory heart failure patients

Moertl

Hammer

Huelsmann

et al. 2008

European J of Heart Fail

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Background: We evaluated the prognostic value of sequential NT-proBNP values in ambulatory heart failure patients after discharge, investigating whether the current value or the recent percent change is more important. Methods and results: In 166 patients, NT-proBNP was measured at discharge from heart failure hospitalisation and three months later. The combined endpoint of death or heart failure rehospitalisation was evaluated after a maximum of 18 months or at follow-up closure. During a mean observation time of 14 ± 4 months, 63 patients (38%) reached the endpoint. In multiple Cox analysis, NT-proBNP three months after discharge (NT-proBNP-3Mo) and NT-proBNP percent change (NT-proBNP-%change) were the only independent predictors of the endpoint among various clinical and laboratory variables. After definition of a high-(n = 83, 57% endpoints) and a low-NT-proBNP patient subgroup (n = 83, 19% endpoints) according to the median NT-proBNP-3Mo (1751 pg/ml), NT-proBNP-%change was the strongest predictor in the high-NT-proBNP subgroup. In the low-NT-proBNP subgroup, NT-proBNP-3Mo was the only independent predictor. Conclusions: In ambulatory heart failure patients, the prognostic value of sequential NT-proBNP measurements depends on the magnitude of the current NT-proBNP value. Recent percent changes in NT-proBNP provide important prognostic information in patients with high NTproBNP but not in patients with low NT-proBNP.

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Section: Discussionsupporting

confidence: 92%

Prognostic value of sequential measurements of amino‐terminal prohormone of B‐type natriuretic peptide in ambulatory heart failure patients

Moertl

Hammer

Huelsmann

et al. 2008

European J of Heart Fail

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show abstract

“…In this regard, the predischarge BNP levels appear to be more predictive of rehospitalization than the commonly performed measurements on admission to the hospital [6,7]. However, the optimal levels able to stratify risk of rehospitalization and other important outcomes are still not known and more clinical research is awaited.…”

Section: Biomarkers Of Neurohormonal Activationmentioning

confidence: 86%

Novel and potential future biomarkers for assessment of the severity and prognosis of chronic heart failure

Virginy

2006

Heart Fail Rev

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Over the last two decades, the pathophysiology and biomolecular basis of heart failure syndrome has reached sound and more comprehensive understanding. This knowledge has allowed expert researchers and clinicians to explore an entirely new spectrum of potential biochemical markers derived from different cellular and signaling pathways that lead to myocardial hypertrophy, chronic damage of the myocyte, apoptosis, and, ultimately, myocardial remodeling. Indeed, the link between myocardial remodeling and adverse outcomes, as well as the recognition of the myocardial interstitium as a multifunctional dynamic entity strongly influenced by systemic neurohormonal and inflammatory activation, has provided a solid ground for research of biomarkers that might correlate with severity and prognostication in chronic heart failure. This paper reviews and summarize recent literature on some of the most interesting circulating biomarkers with potential use for the stratification of patients with chronic heart failure.

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“…Acute MI [8,14,30] or historical MI [9,22] were associated with increased concentrations of B-type natriuretic peptides. However, there was no difference between patients with non-ischemic dilated cardiomyopathy and historical MI [31]. Stable angina was not associated with a difference in Btype natriuretic peptides in one study [14] that included hypertensive patients, but was positively associated in patients who also had non ST-elevation myocardial infarction (NSTEMI) ACS [27].…”

Section: Cardiac Diseasementioning

confidence: 96%

Physiological, pathological, pharmacological, biochemical and hematological factors affecting BNP and NT-proBNP

Balion

Santaguida

McKelvie

et al. 2008

Clinical Biochemistry

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Significance of predischarge BNP on one-year outcome in decompensated heart failure—comparative study with echo-Doppler indexes

Cited by 28 publications

References 21 publications

Prognostic value of sequential measurements of amino‐terminal prohormone of B‐type natriuretic peptide in ambulatory heart failure patients

Prognostic value of sequential measurements of amino‐terminal prohormone of B‐type natriuretic peptide in ambulatory heart failure patients

Novel and potential future biomarkers for assessment of the severity and prognosis of chronic heart failure

Physiological, pathological, pharmacological, biochemical and hematological factors affecting BNP and NT-proBNP

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