Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case‐control study

Abstract

We found a strong association between microscopic colitis and ongoing use of proton pump inhibitors, especially lansoprazole.

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

“…98 Exposure to NSAIDs was also associated with an increased risk of MC (OR 2.40, 95% CI: 1.99-2.89, I 2 ¼ 88%). 54,82,[91][92][93][94][95][97][98][99] The combined use with PPIs might further increase this risk. 98 MC was also associated with SSRI exposure (OR 2.98, 95% CI: 2.35-3.78, I 2 ¼ 90%) 54,81,82,[91][92][93]95,96,98,99 (see also Appendix D, supplementary material).…”

Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re‐evaluated—author's reply

“…The author's declarations of personal and financial interests are unchanged from those in the original article …”

Editorial: proton pump inhibitors (PPIs) and microscopic colitis

“…In recent years, several risk factors related to the development of microscopic colitis have been reported including smoking, NSAIDs and proton pump inhibitors (PPIs). A large nationwide registry study from Denmark investigated the relation between PPI use and microscopic colitis more closely …”

“…Until this paper was published, this relation was not investigated . A comparison of 3 737 cases of microscopic colitis with and without current PPI use showed no increased risk of microscopic colitis with increasing PPI dose . The lack of a dose‐response relation suggests an idiosyncratic adverse reaction.…”