Significant correlations between human cortical bone mineral density and quantitative susceptibility mapping (QSM) obtained with 3D Cones ultrashort echo time magnetic resonance imaging (UTE-MRI)

Dorthé

et al. 2019

NMR in Biomedicine

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Mechanical and microstructural evaluations of cortical bone using ultrashort echo time magnetic resonance imaging (UTE-MRI) have been performed increasingly in recent years. UTE-MRI acquires considerable signal from cortical bone and enables quantitative bone evaluations. Fitting bone apparent transverse magnetization (T2*) decay using a bicomponent model has been regularly performed to estimate bound water (BW) and pore water (PW) in the quantification of bone matrix and porosity, respectively. Human cortical bone possesses a considerable amount of fat, which appears as MRI T2* signal oscillation and can subsequently lead to BW overestimation when using a bicomponent model. Tricomponent T2* fitting model has been developed to improve BW and PW estimations by accounting for fat contribution in the MRI signal. This study aimed to investigate the correlations of microstructural and mechanical properties of human cortical bone with water pool fractions obtained from a tricomponent T2* model. 135 cortical bone strips (~4 × 2 × 40 mm 3 ) from tibial and femoral midshafts of 37 donors (61 ± 24 years old) were scanned using ten sets of dual-echo 3D-UTE-Cones sequences (TE = 0.032-24.0 ms) on a 3 T MRI scanner for T2* fitting analyses. Average bone porosity and pore size were measured using microcomputed tomography (μCT) at 9 μm voxel size. Bone mechanical properties were measured using 4-point bending tests. Using a tricomponent model, bound water fraction (Frac BW ) showed significant strong (R = 0.70, P < 0.01) and moderate (R = 0.58-0.62, P < 0.01) correlations with porosity and mechanical properties, respectively. Correlations of bone microstructural and mechanical properties with water pool fractions were higher for tricomponent model results compared with the bicomponent model. The tricomponent T2* fitting model is suggested as a useful technique for cortical bone evaluation where the MRI contribution of bone fat is accounted for. K E Y W O R D S bone mechanics, cortical bone, fat, MRI, T2* fitting model, ultrashort echo time Abbreviations: 3D, three-dimensional; 3D-UTE, three-dimensional ultrashort echo time imaging; BMD, bone mineral density; CT, computed tomography; DEXA, dual-energy X-ray absorptiometry; FA, flip angle; FOV, field of view; HR-pQCT, peripheral quantitative computed

Section: Introductionmentioning

confidence: 99%

Correlations of cortical bone microstructural and mechanical properties with water proton fractions obtained from ultrashort echo time (UTE) MRI tricomponent T2* model

Dorthé

et al. 2019

NMR in Biomedicine

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“…Local maxima in the QSM map clearly correspond to the regions of high BMD in µCT-based maps. This figure was previously presented by Jerban et al (64). Reprinting permission is granted through Rightslink system.…”

Section: Ute Magnetization Transfer (Ute-mt) Imaging Of Cortical Bonementioning

confidence: 95%

“…They reported significant correlations between radial 3D UTE-QSM values and computed tomography (CT) Hounsfield units in a combined set of ROIs covering tendon, trabecular bone, and cortical bone. Recently, UTE-QSM has been investigated in human tibial cortical bone specimens, and significant correlations between QSM and BMD have been reported (64). Figure 9 illustrates Cones UTE-QSM and volumetric BMD maps for a representative cortical bone specimen from tibial midshaft.…”

Section: Ute Quantitative Susceptibility Mapping (Ute-qsm) Assessmentmentioning

confidence: 99%

Quantitative Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of Bone: An Update

Jang

et al. 2020

Front. Endocrinol.

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Bone possesses a highly complex hierarchical structure comprised of mineral (∼45% by volume), organic matrix (∼35%) and water (∼20%). Water exists in bone in two forms: as bound water (BW), which is bound to bone mineral and organic matrix, or as pore water (PW), which resides in Haversian canals as well as in lacunae and canaliculi. Magnetic resonance (MR) imaging has been increasingly used for assessment of cortical and trabecular bone. However, bone appears as a signal void on conventional MR sequences because of its short T2 *. Ultrashort echo time (UTE) sequences with echo times (TEs) 100-1,000 times shorter than those of conventional sequences allow direct imaging of BW and PW in bone. A series of quantitative UTE MRI techniques has been developed for bone evaluation. UTE and adiabatic inversion recovery prepared UTE (IR-UTE) sequences have been developed to quantify BW and PW. UTE magnetization transfer (UTE-MT) sequences have been developed to quantify collagen backbone protons, and UTE quantitative susceptibility mapping (UTE-QSM) sequences have been developed to assess bone mineral.

“…investigated in human tibial cortical bone specimens, and significant correlations between QSM and BMD were reported. 115 ►Fig. 9 illustrates Cones UTE-MRI QSM and volumetric BMD maps for a representative tibial midshaft bone specimen from a female donor.…”

Section: Quantitative Susceptibility Mapping Assessment Of Bone Mineralsmentioning

confidence: 99%

“…Local maxima in the QSM map correspond qualitatively to the regions of high BMD in micro-CT-based maps. 115 The Phosphorus 31 Assessment of Bone Minerals Bone mineral was estimated in different studies using phosphorus (i.e., 31P) imaging combined with UTE, WASPI, or zero echo time (ZTE) MR acquisitions. 56,57,63,[116][117][118][119][120] Investigations in animal models show that 31P MRI has high sensitivity in detecting impaired mineralization density in hypophosphatemia-induced osteomalacia, as well as effects of antiresorptive treatment at 9.4 T. [118][119][120] The feasibility of in vivo 31P imaging in human subjects was shown at 1.5-T UTE-based tibia and femoral head imaging, 121 3-T WASPI-based wrist bone imaging, 117 and 3-T ZTE-based tibial bone imaging.…”

Section: Quantitative Susceptibility Mapping Assessment Of Bone Mineralsmentioning

confidence: 99%

Quantitative Magnetic Resonance Imaging of Cortical and Trabecular Bone

Semin Musculoskelet Radiol

Wei

et al. 2020

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Bone is a composite material consisting of mineral, organic matrix, and water. Water in bone can be categorized as bound water (BW), which is bound to bone mineral and organic matrix, or as pore water (PW), which resides in Haversian canals as well as in lacunae and canaliculi. Bone is generally classified into two types: cortical bone and trabecular bone. Cortical bone is much denser than trabecular bone that is surrounded by marrow and fat. Magnetic resonance (MR) imaging has been increasingly used for noninvasive assessment of both cortical bone and trabecular bone. Bone typically appears as a signal void with conventional MR sequences because of its short T2*. Ultrashort echo time (UTE) sequences with echo times 100 to 1,000 times shorter than those of conventional sequences allow direct imaging of BW and PW in bone. This article summarizes several quantitative MR techniques recently developed for bone evaluation. Specifically, we discuss the use of UTE and adiabatic inversion recovery prepared UTE sequences to quantify BW and PW, UTE magnetization transfer sequences to quantify collagen backbone protons, UTE quantitative susceptibility mapping sequences to assess bone mineral, and conventional sequences for high-resolution imaging of PW as well as the evaluation of trabecular bone architecture.