Significant high expression of CD23 in follicular lymphoma of the inguinal region

Abstract

There is an unexpectedly high frequency of CD23 expression in FL in general, which is even more pronounced in inguinal nodes.

A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36

“…Second, in a recent article examining CD23 expression in FL, Thorns et al 26 described-apart from an unexpectedly high overall frequency of CD23 positivity in FL-an unusually high coincidence of CD23 staining in FL arising in inguinal lymph nodes (38%). 26 The large majority of these cases, however, were described as typical, predominantly follicular FLs.…”

Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations

“…In addition to the work of Katzenberger et al and our study, at least two other groups have reported that CD23 expression is more common in inguinal follicular lymphoma. 4,5 These had histologic features similar to conventional follicular lymphoma, including follicular growth pattern, CD10 expression, and the presence of t(14;18). Thorns et al 4 reported a diffuse growth pattern in 22% of inguinal follicular lymphoma, but these were not increased relative to follicular lymphoma at other sites (27%) and there was no specific mention of CD23 in the diffuse cases.…”

“…The high proportion of cases with CD23 expression was also unusual for follicular lymphoma, although CD23 expression occasionally is observed in conventional follicular lymphoma and has previously been associated with inguinal involvement. 4,5 Besides t(14;18) IGH/BCL2 rearrangement, other genomic abnormalities in conventional follicular lymphoma have become better elucidated in recent years by a variety of technologies. Follicular lymphoma is generally characterized by genomic gains of chromosomes 2 (and focally of 2p16-p15), 5, 7, 6p, 8 (8q24), 12 (12q12-q13), 17q, 18, 21, and X and losses on 6q (6q23-q24) and 17p.…”

The diagnostic value of biopsy of small peripheral lymph nodes in patients with suspected lymphoma

“…Its management, still unsatisfactory due to the lack of an effective therapy, is mainly based on the treatment of the underlying condition along with the administration of fresh-frozen plasma (FFP) and replacement therapy (such as anti-thrombin [AT]) [3,4]. Recently, the correlation between sepsis and coagulation abnormalities has been intensively investigated [5][6][7]; in septic patients with DIC, substitution therapy with activated recombinant protein C (ar-PC) has been proven to be effective, but with an increase in bleeding [8,9]. The protein C pathway is a modulator of the coagulation system, and PC itself plays an integral role in the host response to infection, immune system, and cancer cells [1,2].…”

“…In patients in whom a lymphoproliferative disorder is suspected, especially if there is evident retroperitoneal adenopathy, the diagnostic yield of inguinal node biopsy may be increased. Thorns et al [5] found that the morphology of follicular lymphomas in inguinal lymph node biopsies did not differ from lymphoma biopsies taken from other sites.…”